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LRRC37A2 leucine rich repeat containing 37 member A2 [ Homo sapiens (human) ]

Gene ID: 474170, updated on 3-Apr-2024

Summary

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Official Symbol
LRRC37A2provided by HGNC
Official Full Name
leucine rich repeat containing 37 member A2provided by HGNC
Primary source
HGNC:HGNC:32404
See related
Ensembl:ENSG00000238083 MIM:616556; AllianceGenome:HGNC:32404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRRC37
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 18.7), bone marrow (RPKM 5.7) and 23 other tissues See more
Orthologs
all
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Genomic context

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See LRRC37A2 in Genome Data Viewer
Location:
17q21.31-q21.32
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (46372792..47049128)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (47234775..47910589)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (44589834..44633014)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904014 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:44361168-44362367 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:44365530-44366030 Neighboring gene leucine rich repeat containing 37A Neighboring gene ADP ribosylation factor like GTPase 17B Neighboring gene RNA, 7SL, cytoplasmic 656, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7330 Neighboring gene N-ethylmaleimide-sensitive factor pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44569061-44569562 Neighboring gene RNA, 7SL, cytoplasmic 199, pseudogene Neighboring gene ADP ribosylation factor like GTPase 17A Neighboring gene RDM1 pseudogene 2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:44704776-44705308 Neighboring gene N-ethylmaleimide sensitive factor, vesicle fusing ATPase Neighboring gene vesicle-associated membrane protein 5-like Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:44809975-44810751 Neighboring gene Sharpr-MPRA regulatory region 12503 Neighboring gene Sharpr-MPRA regulatory region 3126 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44849369-44850026 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44850027-44850682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44850683-44851340 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44851341-44851996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44853512-44854187 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44859348-44860034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44862602-44863519 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44863520-44864436 Neighboring gene ribosomal protein S7 pseudogene 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44886481-44887010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44887011-44887538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44891812-44892716 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44897113-44897700 Neighboring gene uncharacterized LOC101929777 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44909071-44909718 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44909719-44910366 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44910367-44911014 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:44922250-44922415 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44941567-44942392 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:44941221-44941463 Neighboring gene Wnt family member 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44953785-44954385 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44955695-44956194 Neighboring gene Sharpr-MPRA regulatory region 3811 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44967346-44967846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44971730-44972350 Neighboring gene uncharacterized LOC112268191 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45000502-45001226 Neighboring gene Wnt family member 9B Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:45008344-45009543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:45020222-45021158 Neighboring gene RNA, U6atac small nuclear 3, pseudogene Neighboring gene long intergenic non-protein coding RNA 1974 Neighboring gene Sharpr-MPRA regulatory region 11668 Neighboring gene GOSR2 divergent transcript Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:45054724-45055404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:45055405-45056084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8620 Neighboring gene uncharacterized LOC101927060 Neighboring gene Sharpr-MPRA regulatory region 6393 Neighboring gene golgi SNAP receptor complex member 2 Neighboring gene microRNA 5089 Neighboring gene leucine rich repeat containing 37 member A17, pseudogene Neighboring gene MPRA-validated peak2870 silencer Neighboring gene reprimo like Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45145515-45146016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45146017-45146516 Neighboring gene uncharacterized LOC124904015 Neighboring gene RNA, 7SL, cytoplasmic 270, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:45175453-45176078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8621 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:45197166-45197776 Neighboring gene protein GVQW1-like Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:45213296-45214495 Neighboring gene cell division cycle 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region. Bekpen C, et al. Genome Res, 2012 Jun. PMID 22419166, Free PMC Article
  2. Evolutionary dynamism of the primate LRRC37 gene family. Giannuzzi G, et al. Genome Res, 2013 Jan. PMID 23064749, Free PMC Article
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Zody MC, et al. Nature, 2006 Apr 20. PMID 16625196, Free PMC Article
  4. Isoform-specific GSK3A activity is negatively correlated with human sperm motility. Freitas MJ, et al. Mol Hum Reprod, 2019 Apr 1. PMID 30824926, Free PMC Article
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ45049

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 37A2
Names
c114 SLIT-like testicular protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006607.3 → NP_001006608.2  leucine-rich repeat-containing protein 37A2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001006608.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC138645
    Consensus CDS
    CCDS42353.1
    UniProtKB/Swiss-Prot
    A6NM11, B7ZMC3
    UniProtKB/TrEMBL
    A0A0G2JNC9
    Related
    ENSP00000459551.1, ENST00000576629.6
    Conserved Domains (5) summary
    sd00031
    Location:891 → 914
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:892 → 929
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:892 → 949
    LRR_8; Leucine rich repeat
    pfam14914
    Location:1468 → 1613
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561 → 629
    LRRC37; Leucine-rich repeat-containing protein 37 family

  2. NM_001385803.1 → NP_001372732.1  leucine-rich repeat-containing protein 37A2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC138645
    UniProtKB/TrEMBL
    A0A0G2JNC9
    Conserved Domains (7) summary
    COG4886
    Location:866 → 1045
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    PRK10263
    Location:206 → 704
    PRK10263; DNA translocase FtsK; Provisional
    sd00031
    Location:891 → 914
    LRR_1; leucine-rich repeat [structural motif]
    NF033395
    Location:113 → 266
    fibronec_SfbI; fibronectin-binding protein SfbI
    pfam13855
    Location:892 → 949
    LRR_8; Leucine rich repeat
    pfam14914
    Location:1468 → 1613
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:560 → 629
    LRRC37; Leucine-rich repeat-containing protein 37 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    46372792..47049128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436147.1 → XP_047292103.1  leucine-rich repeat-containing protein 37A2 isoform X12

  2. XM_047436145.1 → XP_047292101.1  leucine-rich repeat-containing protein 37A2 isoform X11

  3. XM_047436146.1 → XP_047292102.1  leucine-rich repeat-containing protein 37A2 isoform X16

  4. XM_047436143.1 → XP_047292099.1  leucine-rich repeat-containing protein 37A2 isoform X6

  5. XM_047436144.1 → XP_047292100.1  leucine-rich repeat-containing protein 37A2 isoform X8

  6. XM_024450773.2 → XP_024306541.1  leucine-rich repeat-containing protein 37A2 isoform X15

    UniProtKB/TrEMBL
    A8MUI5
    Conserved Domains (5) summary
    sd00031
    Location:891 → 914
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:892 → 949
    LRR_8; Leucine rich repeat
    pfam14914
    Location:1468 → 1602
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:571 → 629
    LRRC37; Leucine-rich repeat-containing protein 37 family
    cl28087
    Location:144 → 704
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  7. XM_011524842.4 → XP_011523144.1  leucine-rich repeat-containing protein 37A2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JNC9
    Conserved Domains (5) summary
    sd00031
    Location:891 → 914
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:892 → 929
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:892 → 949
    LRR_8; Leucine rich repeat
    pfam14914
    Location:1468 → 1578
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561 → 629
    LRRC37; Leucine-rich repeat-containing protein 37 family

  8. XM_011524843.4 → XP_011523145.1  leucine-rich repeat-containing protein 37A2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JNC9
    Conserved Domains (5) summary
    sd00031
    Location:868 → 890
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:892 → 929
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:892 → 949
    LRR_8; Leucine rich repeat
    pfam14914
    Location:1419 → 1564
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561 → 629
    LRRC37; Leucine-rich repeat-containing protein 37 family

  9. XM_011524841.4 → XP_011523143.1  leucine-rich repeat-containing protein 37A2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JNC9
    Conserved Domains (5) summary
    sd00031
    Location:868 → 890
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:892 → 929
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:892 → 952
    LRR_8; Leucine rich repeat
    pfam14914
    Location:1444 → 1589
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561 → 629
    LRRC37; Leucine-rich repeat-containing protein 37 family

  10. XM_011524844.4 → XP_011523146.1  leucine-rich repeat-containing protein 37A2 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JNC9
    Conserved Domains (5) summary
    sd00031
    Location:868 → 890
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:914 → 956
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:868 → 925
    LRR_8; Leucine rich repeat
    pfam14914
    Location:1417 → 1562
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561 → 629
    LRRC37; Leucine-rich repeat-containing protein 37 family

  11. XM_011524848.4 → XP_011523150.1  leucine-rich repeat-containing protein 37A2 isoform X7

    UniProtKB/TrEMBL
    A0A994J7J8
    Related
    ENSP00000516210.1, ENST00000706058.1
    Conserved Domains (4) summary
    sd00031
    Location:868 → 890
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:868 → 920
    LRR_8; Leucine rich repeat
    pfam14914
    Location:1368 → 1513
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561 → 629
    LRRC37; Leucine-rich repeat-containing protein 37 family

  12. XM_011524846.4 → XP_011523148.1  leucine-rich repeat-containing protein 37A2 isoform X5

    UniProtKB/TrEMBL
    A0A994J7J8
    Conserved Domains (3) summary
    sd00031
    Location:868 → 890
    LRR_1; leucine-rich repeat [structural motif]
    pfam14914
    Location:1393 → 1538
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561 → 629
    LRRC37; Leucine-rich repeat-containing protein 37 family

  13. XM_047436141.1 → XP_047292097.1  leucine-rich repeat-containing protein 37A2 isoform X13

  14. XM_047436142.1 → XP_047292098.1  leucine-rich repeat-containing protein 37A2 isoform X14

  15. XM_011524850.4 → XP_011523152.1  leucine-rich repeat-containing protein 37A2 isoform X10

    Conserved Domains (4) summary
    sd00031
    Location:868 → 890
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:892 → 929
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:892 → 949
    LRR_8; Leucine rich repeat
    pfam15779
    Location:561 → 629
    LRRC37; Leucine-rich repeat-containing protein 37 family

  16. XM_011524849.3 → XP_011523151.1  leucine-rich repeat-containing protein 37A2 isoform X9

    Conserved Domains (4) summary
    sd00031
    Location:891 → 914
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:892 → 929
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:892 → 949
    LRR_8; Leucine rich repeat
    pfam15779
    Location:561 → 629
    LRRC37; Leucine-rich repeat-containing protein 37 family

RNA

  1. XR_007065300.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167251.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    195713..378581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328575.1 → XP_054184550.1  leucine-rich repeat-containing protein 37A2 isoform X17

  2. XM_054328574.1 → XP_054184549.1  leucine-rich repeat-containing protein 37A2 isoform X11

  3. XM_054328573.1 → XP_054184548.1  leucine-rich repeat-containing protein 37A2 isoform X6

  4. XM_054328577.1 → XP_054184552.1  leucine-rich repeat-containing protein 37A2 isoform X12

  5. XM_054328576.1 → XP_054184551.1  leucine-rich repeat-containing protein 37A2 isoform X12

  6. XM_054328578.1 → XP_054184553.1  leucine-rich repeat-containing protein 37A2 isoform X18

RNA

  1. XR_008485599.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187663.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    1032151..1075353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    47234775..47910589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316266.1 → XP_054172241.1  leucine-rich repeat-containing protein 37A2 isoform X12

  2. XM_054316263.1 → XP_054172238.1  leucine-rich repeat-containing protein 37A2 isoform X11

  3. XM_054316264.1 → XP_054172239.1  leucine-rich repeat-containing protein 37A2 isoform X20

  4. XM_054316265.1 → XP_054172240.1  leucine-rich repeat-containing protein 37A2 isoform X21

  5. XM_054316262.1 → XP_054172237.1  leucine-rich repeat-containing protein 37A2 isoform X19

  6. XM_054316257.1 → XP_054172232.1  leucine-rich repeat-containing protein 37A2 isoform X6

  7. XM_054316259.1 → XP_054172234.1  leucine-rich repeat-containing protein 37A2 isoform X8

  8. XM_054316253.1 → XP_054172228.1  leucine-rich repeat-containing protein 37A2 isoform X2

  9. XM_054316254.1 → XP_054172229.1  leucine-rich repeat-containing protein 37A2 isoform X3

  10. XM_054316252.1 → XP_054172227.1  leucine-rich repeat-containing protein 37A2 isoform X1

  11. XM_054316255.1 → XP_054172230.1  leucine-rich repeat-containing protein 37A2 isoform X4

  12. XM_054316258.1 → XP_054172233.1  leucine-rich repeat-containing protein 37A2 isoform X7

  13. XM_054316256.1 → XP_054172231.1  leucine-rich repeat-containing protein 37A2 isoform X5

  14. XM_054316261.1 → XP_054172236.1  leucine-rich repeat-containing protein 37A2 isoform X10

  15. XM_054316260.1 → XP_054172235.1  leucine-rich repeat-containing protein 37A2 isoform X9

RNA

  1. XR_008484825.1 RNA Sequence

  2. XR_008484824.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NM11.2 GenPept UniProtKB/Swiss-Prot:A6NM11

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