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MT-TQ mitochondrially encoded tRNA glutamine [ Homo sapiens (human) ]

Gene ID: 4572, updated on 10-Oct-2023

Summary

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Official Symbol
MT-TQprovided by HGNC
Official Full Name
mitochondrially encoded tRNA glutamineprovided by HGNC
Primary source
HGNC:HGNC:7495
See related
MIM:590030; AllianceGenome:HGNC:7495
Gene type
tRNA
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTTQ; TRNQ
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Genomic context

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See MT-TQ in Genome Data Viewer
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) MT (non-nuclear) NC_012920.1 (4329..4400, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) MT (non-nuclear) NC_012920.1 (4329..4400, complement)

Chromosome MT - NC_012920.1Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene NADH dehydrogenase subunit 1 Neighboring gene tRNA-Ile Neighboring gene tRNA-Met Neighboring gene NADH dehydrogenase subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Mitochondrial DNA mutation associated with hypertension in tRNA(Ile) and tRNA(Gln) genes]. Zhu C, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2014 Oct. PMID 25297595
  2. A mitochondrial mutation A4401G is involved in the pathogenesis of left ventricular hypertrophy in Chinese hypertensives. Zhu HY, et al. Eur J Hum Genet, 2009 Feb. PMID 18701880, Free PMC Article
  3. The European-specific mitochondrial cluster J/T could confer an increased risk of insulin-resistance and type 2 diabetes: an analysis of the m.4216T > C and m.4917A > G variants. Crispim D, et al. Ann Hum Genet, 2006 Jul. PMID 16759180
  4. No association between Parkinson's disease and three polymorphisms in the eNOS, nNOS, and iNOS genes. Huerta C, et al. Neurosci Lett, 2007 Feb 21. PMID 17174475
  5. MELAS. Adam MP, et al. , 1993. PMID 20301411

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that the 4329C> G point mutation in mitochondrial transfer RNA genes tRNA(Ile) and tRNA(Gln) probably contributed to the pathogenesis of hypertension, possibly in association with other modifying factors.
    Title: [Mitochondrial DNA mutation associated with hypertension in tRNA(Ile) and tRNA(Gln) genes].
  2. The noncoding mitochondrial sequence alteration (A4401G) at the junction of tRNA(Met) and tRNA(Gln) alters mitochondrial function, implicating this mutation in the pathogenesis of left ventricular hypertrophy in Chinese hypertensives.
    Title: A mitochondrial mutation A4401G is involved in the pathogenesis of left ventricular hypertrophy in Chinese hypertensives.
  3. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: No association between Parkinson's disease and three polymorphisms in the eNOS, nNOS, and iNOS genes.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: MtSNPscore: a combined evidence approach for assessing cumulative impact of mitochondrial variations in disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

  • NAR: 0597

Gene LinkOut

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Other Literature Sources
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Research Materials