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capt capulet [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45233, updated on 11-Apr-2024

Summary

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Official Symbol
captprovided by FlyBase
Official Full Name
capuletprovided by FlyBase
Primary source
FLYBASE:FBgn0261458
Locus tag
Dmel_CG33979
See related
AllianceGenome:FB:FBgn0261458
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Acap; acu; BcDNA:LD24380; cap; Cap; CAP; capping protein; Capt; Capulet; CG33979; CG5061; CG5074; CP; cyclase-associated protein; Dcap; Dmel\CG33979; l(2)06955; punc
Summary
Predicted to enable actin binding activity and adenylate cyclase binding activity. Involved in several processes, including cytoskeleton organization; muscle cell cellular homeostasis; and neuron development. Located in cytoplasm. Is expressed in several structures, including embryonic/larval nervous system; extended germ band embryo; eye-antennal disc; gastrula embryo; and presumptive embryonic/larval system. Orthologous to human CAP1 (cyclase associated actin cytoskeleton regulatory protein 1) and CAP2 (cyclase associated actin cytoskeleton regulatory protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
21F1-21F1; 2-2 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1151678..1158262, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1151678..1158262, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45717 Neighboring gene Major Facilitator Superfamily Transporter 3 Neighboring gene lethal (2) 10685 Neighboring gene Transcription factor B4 Neighboring gene Vacuolar protein sorting 29 Neighboring gene antisense RNA:CR43767 Neighboring gene Transport and Golgi organization 14 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Capulet and Slingshot share overlapping functions during Drosophila eye morphogenesis. Lin CM, et al. J Biomed Sci, 2012 Apr 30. PMID 22545588, Free PMC Article
  2. Identification of DCAP, a drosophila homolog of a glucose transport regulatory complex. Yamazaki H, et al. Mech Dev, 2002 Nov. PMID 12385759
  3. Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover. Jodoin JN, et al. Dev Cell, 2015 Dec 21. PMID 26688336, Free PMC Article
  4. The actin-binding protein capulet genetically interacts with the microtubule motor kinesin to maintain neuronal dendrite homeostasis. Medina PM, et al. PLoS One, 2008 Aug 25. PMID 18725959, Free PMC Article
  5. A novel forward genetic screen for identifying mutations affecting larval neuronal dendrite development in Drosophila melanogaster. Medina PM, et al. Genetics, 2006 Apr. PMID 16415365, Free PMC Article

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we found that Capt(Capulet) and Ssh(Slingshot), but not Tsr, share overlapping functions during eye morphogenesis
    Title: Capulet and Slingshot share overlapping functions during Drosophila eye morphogenesis.
  2. Molecularly defined loss of function demonstration of actin-cofilin rods in vivo suggests that perturbations in dendrites can synergize producing severe abnormalities in mitochondria in dendrites.
    Title: The actin-binding protein capulet genetically interacts with the microtubule motor kinesin to maintain neuronal dendrite homeostasis.
  3. DCAP is predominantly expressed in the midgut and fat bodies of late-stage embryos, suggesting a role in insulin-mediated glucose transport in these organs
    Title: Identification of DCAP, a drosophila homolog of a glucose transport regulatory complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chaeta morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle cell cellular homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in oocyte microtubule cytoskeleton polarization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in photoreceptor cell axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rhabdomere development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wing disc dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
capulet
Names
Act up
CG33979-PA
CG33979-PB
CG33979-PC
Cyclase-associated protein
adenylyl cyclase-associated protein
capt-PA
capt-PB
capt-PC
cyclase associated protein capulet
punctate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    1151678..1158262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001038780.2 → NP_001033869.1  capulet, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033869.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KN55, Q9VPX7, Q9XZ60
    Conserved Domains (3) summary
    smart00673
    Location:343 → 380
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:1 → 245
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:274 → 422
    CAP_C; Adenylate cyclase associated (CAP) C terminal

  2. NM_001272927.1 → NP_001259856.1  capulet, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259856.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KN55, Q9VPX7, Q9XZ60
    Conserved Domains (3) summary
    smart00673
    Location:343 → 380
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:1 → 245
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:274 → 422
    CAP_C; Adenylate cyclase associated (CAP) C terminal

  3. NM_001038781.2 → NP_001033870.1  capulet, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033870.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BII8, Q9VPX6
    Conserved Domains (3) summary
    smart00673
    Location:702 → 739
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:299 → 604
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:633 → 781
    CAP_C; Adenylate cyclase associated (CAP) C terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KN55 Q7KN55
Q9VPX6 Q9VPX6
Q9VPX7 Q9VPX7

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