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Fbxl7 F-box and leucine-rich repeat protein 7 [ Mus musculus (house mouse) ]

Gene ID: 448987, updated on 5-Mar-2024

Summary

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Official Symbol
Fbxl7provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 7provided by MGI
Primary source
MGI:MGI:3052506
See related
Ensembl:ENSMUSG00000043556 AllianceGenome:MGI:3052506
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBL7; Fbl6; D230018M15Rik
Summary
Involved in G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Located in centrosome. Part of SCF ubiquitin ligase complex. Orthologous to human FBXL7 (F-box and leucine rich repeat protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 5.8), ovary adult (RPKM 5.0) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Fbxl7 in Genome Data Viewer
Location:
15 B1; 15 9.87 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (26540540..26895650, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (26540454..26895564, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene membrane associated ring-CH-type finger 11 Neighboring gene STARR-seq mESC enhancer starr_38209 Neighboring gene STARR-seq mESC enhancer starr_38210 Neighboring gene predicted gene, 36790 Neighboring gene predicted gene, 52206 Neighboring gene STARR-seq mESC enhancer starr_38211 Neighboring gene predicted gene, 52205 Neighboring gene gem-associated protein 4-like Neighboring gene ecdysoneless homolog pseudogene Neighboring gene predicted gene, 18093 Neighboring gene STARR-seq mESC enhancer starr_38213 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 23903

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest. Coon TA, et al. Cell Cycle, 2012 Feb 15. PMID 22306998, Free PMC Article
  2. The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin. Liu Y, et al. J Biol Chem, 2015 May 8. PMID 25778398, Free PMC Article
  3. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
  4. Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. Benleulmi-Chaachoua A, et al. J Pineal Res, 2016 Jan. PMID 26514267
  5. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the Skp1.Cul1.F-box protein complex subunit Fbxl7 modulates mitochondrial function by controlling the cellular abundance of survivin
    Title: The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin.
  2. FBXL7 specifically interacts with Aurora A during mitosis but not in interphase, suggesting a regulatory role for FBXL7 in controlling Aurora A abundance during mitosis.
    Title: Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102204

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
F-box/LRR-repeat protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176959.3 → NP_795933.2  F-box/LRR-repeat protein 7

    See identical proteins and their annotated locations for NP_795933.2

    Status: PROVISIONAL

    Source sequence(s)
    BC091646
    Consensus CDS
    CCDS37052.1
    UniProtKB/Swiss-Prot
    Q5BJ29, Q6ZQ36
    Related
    ENSMUSP00000061305.10, ENSMUST00000059204.11
    Conserved Domains (3) summary
    cd09293
    Location:297 → 464
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:240 → 273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:114 → 160
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    26540540..26895650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520106.5 → XP_006520169.1  F-box/LRR-repeat protein 7 isoform X1

    See identical proteins and their annotated locations for XP_006520169.1

    Conserved Domains (3) summary
    cd09293
    Location:250 → 417
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:193 → 226
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:67 → 110
    F-box-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BJ29.1 GenPept UniProtKB/Swiss-Prot:Q5BJ29

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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