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Znhit3 zinc finger, HIT type 3 [ Mus musculus (house mouse) ]

Gene ID: 448850, updated on 5-Mar-2024

Summary

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Official Symbol
Znhit3provided by MGI
Official Full Name
zinc finger, HIT type 3provided by MGI
Primary source
MGI:MGI:3051596
See related
Ensembl:ENSMUSG00000020526 AllianceGenome:MGI:3051596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trip3; Myohd1; TRIP-3
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in box C/D snoRNP assembly; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and snoRNA localization. Predicted to be located in cytoplasm. Predicted to be part of pre-snoRNP complex. Predicted to be active in nucleus. Is expressed in liver; pancreas; submandibular gland primordium; thymus primordium; and vibrissa. Human ortholog(s) of this gene implicated in PEHO syndrome. Orthologous to human ZNHIT3 (zinc finger HIT-type containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 23.4), colon adult (RPKM 15.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 C; 11 51.34 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (84801776..84807192, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84910950..84916366, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene gametogenetin binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E7033 Neighboring gene gametogenetin binding protein 2, opposite strand Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class W Neighboring gene myosin XIX Neighboring gene predicted gene, 33028 Neighboring gene predicted gene, 32917 Neighboring gene carbonic anhydrase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
  2. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  3. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Clone Names

  • MGC107312

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in box C/D snoRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snoRNA localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of pre-snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger HIT domain-containing protein 3
Names
TR-interacting protein 3
myosin head domain containing 1
thyroid hormone receptor interactor 3
thyroid receptor-interacting protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005223.3 → NP_001005223.1  zinc finger HIT domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001005223.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (1).
    Source sequence(s)
    AI851492, AK004259, AK014350
    Consensus CDS
    CCDS25189.1
    UniProtKB/Swiss-Prot
    Q9CQK1
    Related
    ENSMUSP00000099484.5, ENSMUST00000103195.5
    Conserved Domains (1) summary
    pfam04438
    Location:7 → 36
    zf-HIT; HIT zinc finger

  2. NM_001359182.1 → NP_001346111.1  zinc finger HIT domain-containing protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AI851492, AK014350, BC089554
    UniProtKB/TrEMBL
    Q5FW88

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    84801776..84807192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQK1.1 GenPept UniProtKB/Swiss-Prot:Q9CQK1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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