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Xrra1 X-ray radiation resistance associated 1 [ Mus musculus (house mouse) ]

Gene ID: 446101, updated on 5-Mar-2024

Summary

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Official Symbol
Xrra1provided by MGI
Official Full Name
X-ray radiation resistance associated 1provided by MGI
Primary source
MGI:MGI:2181647
See related
Ensembl:ENSMUSG00000035211 AllianceGenome:MGI:2181647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in response to X-ray. Predicted to be located in cytoplasm and nuclear body. Predicted to be active in nucleus. Orthologous to human XRRA1 (X-ray radiation resistance associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 88.3), adrenal adult (RPKM 15.3) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
7 E1- E2; 7 54.15 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99508425..99567031)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (99859218..99917824)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily AT member 1 Neighboring gene olfactory receptor enhancer Ikaria Neighboring gene STARR-positive B cell enhancer ABC_E3735 Neighboring gene STARR-seq mESC enhancer starr_19662 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:106976805-106976914 Neighboring gene STARR-positive B cell enhancer ABC_E3736 Neighboring gene neuraminidase 3 Neighboring gene signal peptidase complex subunit 2 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E1347 Neighboring gene predicted gene, 38405 Neighboring gene ring finger protein 169 Neighboring gene predicted gene 5115 Neighboring gene U2 small nuclear RNA auxiliary factor 1-like 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning, genomic characterization and over-expression of a novel gene, XRRA1, identified from human colorectal cancer cell HCT116Clone2_XRR and macaque testis. Mesak FM, et al. BMC Genomics, 2003 Aug 9. PMID 12908878, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in response to X-ray ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
X-ray radiation resistance-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164258.1 → NP_001157730.1  X-ray radiation resistance-associated protein 1

    See identical proteins and their annotated locations for NP_001157730.1

    Status: VALIDATED

    Source sequence(s)
    BC151014, BK000542
    Consensus CDS
    CCDS52321.1
    UniProtKB/Swiss-Prot
    B2RX67, Q3U3V8, Q7M740
    UniProtKB/TrEMBL
    A0A991ENW4
    Related
    ENSMUSP00000035929.9, ENSMUST00000036155.10
    Conserved Domains (3) summary
    PRK15370
    Location:237 → 421
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    COG4886
    Location:136 → 276
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:147 → 169
    LRR_1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    99508425..99567031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322345.2 → XP_017177834.1  X-ray radiation resistance-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A991ENW4
    Conserved Domains (3) summary
    PRK15370
    Location:239 → 423
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    COG4886
    Location:138 → 278
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:149 → 171
    LRR_1; leucine-rich repeat [structural motif]

  2. XM_006508007.4 → XP_006508070.1  X-ray radiation resistance-associated protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006508070.1

    UniProtKB/Swiss-Prot
    B2RX67, Q3U3V8, Q7M740
    UniProtKB/TrEMBL
    A0A991ENW4
    Conserved Domains (3) summary
    PRK15370
    Location:237 → 421
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    COG4886
    Location:136 → 276
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:147 → 169
    LRR_1; leucine-rich repeat [structural motif]

  3. XM_017322346.1 → XP_017177835.1  X-ray radiation resistance-associated protein 1 isoform X3

    Related
    ENSMUST00000208449.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U3V8.1 GenPept UniProtKB/Swiss-Prot:Q3U3V8

Gene LinkOut

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