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SULT1A4 sulfotransferase family 1A member 4 [ Homo sapiens (human) ]

Gene ID: 445329, updated on 5-Mar-2024

Summary

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Official Symbol
SULT1A4provided by HGNC
Official Full Name
sulfotransferase family 1A member 4provided by HGNC
Primary source
HGNC:HGNC:30004
See related
Ensembl:ENSG00000213648 MIM:615819; AllianceGenome:HGNC:30004
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STM; HAST3; M-PST; ST1A3; ST1A4; TL-PST; ST1A3/ST1A4
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A3 arose from a segmental duplication. Read-through transcription exists between this gene and the upstream SLX1B (SLX1 structure-specific endonuclease subunit homolog B) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]
Expression
Broad expression in duodenum (RPKM 135.4), small intestine (RPKM 94.3) and 23 other tissues See more
Orthologs
all
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Genomic context

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Location:
16p11.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (29459913..29464966)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (29741703..29746756)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29471234..29476287)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene BOLA2-SMG1P6 readthrough Neighboring gene coronin 1A pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:29465349-29466088 Neighboring gene SLX1B-SULT1A4 readthrough (NMD candidate) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:29466829-29467566 Neighboring gene bolA family member 2 Neighboring gene SLX1 homolog B, structure-specific endonuclease subunit Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:29470053-29470888 Neighboring gene SAGA complex associated factor 29 pseudogene Neighboring gene phospholipase A2 group XH, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Impact of SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of phenylephrine and salbutamol by human SULT1A3 allozymes. Bairam AF, et al. Pharmacogenet Genomics, 2019 Jul. PMID 31145702, Free PMC Article
  2. Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3. Bairam AF, et al. Arch Biochem Biophys, 2018 Jun 15. PMID 29705271, Free PMC Article
  3. Phylogenomic approaches to common problems encountered in the analysis of low copy repeats: the sulfotransferase 1A gene family example. Bradley ME, et al. BMC Evol Biol, 2005 Mar 7. PMID 15752422, Free PMC Article
  4. Crystal structure of human catecholamine sulfotransferase. Bidwell LM, et al. J Mol Biol, 1999 Oct 29. PMID 10543947
  5. Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization. Wood TC, et al. Biochem Biophys Res Commun, 1994 Feb 15. PMID 8117269

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results obtained showed clearly the differential enzymatic characteristics of SULT1A3 allozymes in mediating the sulfation of phenylephrine and salbutamol. This information may contribute toward a better understanding of the pharmacokinetics of these two drugs in individuals with distinct SULT1A3 and/or SULT1A4 genotypes.
    Title: Impact of SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of phenylephrine and salbutamol by human SULT1A3 allozymes.
  2. Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3
    Title: Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough SLX1B-SULT1A4

Readthrough gene: SLX1B-SULT1A4, Included gene: SLX1B

Homology

Clone Names

  • FLJ54864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables amine sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aryl sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aryl sulfotransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sulfate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in catecholamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to dopamine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dopamine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ethanol catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in flavonoid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
sulfotransferase 1A4
Names
SLX1B-SULT1A4
Sulfotransferase 1A3
aryl sulfotransferase 1A3/1A4
catecholamine-sulfating phenol sulfotransferase
monoamine-sulfating phenol sulfotransferase
placental estrogen sulfotransferase
sulfokinase
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase, monoamine-preferring
thermolabile phenol sulfotransferase
NP_001017390.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017390.3 → NP_001017390.1  sulfotransferase 1A4

    See identical proteins and their annotated locations for NP_001017390.1

    Status: REVIEWED

    Source sequence(s)
    AC133555
    Consensus CDS
    CCDS32427.1
    UniProtKB/Swiss-Prot
    B4DNV0, O95603, P0DMM9, P0DMN0, P50224, Q1ET66, Q6ZWJ5
    UniProtKB/TrEMBL
    B3KT14, Q1ET61, Q1ET62, Q1ET63, Q2TAB3
    Related
    ENSP00000353600.8, ENST00000360423.12
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 287
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    29459913..29464966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    29741703..29746756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001017389.1: Suppressed sequence

    Description
    NM_001017389.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_001017391.1: Suppressed sequence

    Description
    NM_001017391.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DMM9.1 GenPept UniProtKB/Swiss-Prot:P0DMM9
P0DMN0.1 GenPept UniProtKB/Swiss-Prot:P0DMN0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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