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Nup85 nucleoporin 85 [ Mus musculus (house mouse) ]

Gene ID: 445007, updated on 25-Apr-2024

Summary

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Official Symbol
Nup85provided by MGI
Official Full Name
nucleoporin 85provided by MGI
Primary source
MGI:MGI:3046173
See related
Ensembl:ENSMUSG00000020739 AllianceGenome:MGI:3046173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pcnt1; frount
Summary
Predicted to enable CCR2 chemokine receptor binding activity. Predicted to be a structural constituent of nuclear pore. Acts upstream of or within lamellipodium assembly and macrophage chemotaxis. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of nuclear pore outer ring. Predicted to colocalize with kinetochore. Is expressed in several structures, including blastocyst; early embryo; and extraembryonic component. Human ortholog(s) of this gene implicated in nephrotic syndrome type 17. Orthologous to human NUP85 (nucleoporin 85). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 39.0), CNS E11.5 (RPKM 38.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 80.87 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115455264..115474750)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115564432..115583924)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Jupiter microtubule associated homolog 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115374372-115374555 Neighboring gene STARR-positive B cell enhancer ABC_E470 Neighboring gene small ubiquitin-like modifier 2 Neighboring gene STARR-positive B cell enhancer ABC_E4015 Neighboring gene STARR-seq mESC enhancer starr_31164 Neighboring gene STARR-positive B cell enhancer ABC_E8882 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_31165 Neighboring gene predicted gene, 25364 Neighboring gene mitchondrial ribosomal protein S7 Neighboring gene MIF4G domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deficient chaperone-mediated autophagy in macrophage aggravates inflammation of nonalcoholic steatohepatitis by targeting Nup85. Zhang M, et al. Liver Int, 2023 May. PMID 36912786
  2. Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties. Terashima Y, et al. Nat Commun, 2020 Jan 30. PMID 32001710, Free PMC Article
  3. Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis. Terashima Y, et al. Nat Immunol, 2005 Aug. PMID 15995708
  4. Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. Dietrich JE, et al. EMBO Rep, 2015 Aug. PMID 26142281, Free PMC Article
  5. Peering through the pore: nuclear pore complex structure, assembly, and function. Suntharalingam M, et al. Dev Cell, 2003 Jun. PMID 12791264

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease.
    Title: NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease.
  2. Deficient chaperone-mediated autophagy in macrophage aggravates inflammation of nonalcoholic steatohepatitis by targeting Nup85.
    Title: Deficient chaperone-mediated autophagy in macrophage aggravates inflammation of nonalcoholic steatohepatitis by targeting Nup85.
  3. the chemokine signal regulator FROUNT is identified as a target to control tumor-associated macrophages.
    Title: Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties.
  4. FROUNT links activated CCR2 to the PI(3)K-Rac-lamellipodium protrusion cascade in monocyte chemotaxis
    Title: Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105225

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CCR2 chemokine receptor binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cytokine-mediated signaling pathway ISA
Inferred from Sequence Alignment
more info
 PubMed 
acts_upstream_of_or_within lamellipodium assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within macrophage chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nephron development ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore NAS
Non-traceable Author Statement
more info
 PubMed 
part_of nuclear pore outer ring IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore outer ring ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISA
Inferred from Sequence Alignment
more info
 PubMed 

General protein information

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Preferred Names
nuclear pore complex protein Nup85
Names
85 kDa nucleoporin
nucleoporin Nup85
pericentrin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002929.4 → NP_001002929.3  nuclear pore complex protein Nup85

    See identical proteins and their annotated locations for NP_001002929.3

    Status: VALIDATED

    Source sequence(s)
    BC079856, BY032258, CF738553
    Consensus CDS
    CCDS25640.1
    UniProtKB/Swiss-Prot
    A2A9W9, A2A9X0, Q8R480, Q9CYI9
    Related
    ENSMUSP00000021085.5, ENSMUST00000021085.11
    Conserved Domains (1) summary
    pfam07575
    Location:53 → 606
    Nucleopor_Nup85; Nup85 Nucleoporin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115455264..115474750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533670.5 → XP_006533733.1  nuclear pore complex protein Nup85 isoform X1

    Conserved Domains (1) summary
    pfam07575
    Location:53 → 598
    Nucleopor_Nup85; Nup85 Nucleoporin

  2. XM_006533671.4 → XP_006533734.1  nuclear pore complex protein Nup85 isoform X2

    Conserved Domains (1) summary
    pfam07575
    Location:31 → 584
    Nucleopor_Nup85; Nup85 Nucleoporin

  3. XM_030246116.2 → XP_030101976.1  nuclear pore complex protein Nup85 isoform X3

    Conserved Domains (1) summary
    pfam07575
    Location:31 → 576
    Nucleopor_Nup85; Nup85 Nucleoporin

RNA

  1. XR_004936985.1 RNA Sequence

  2. XR_388489.5 RNA Sequence

  3. XR_004936986.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R480.1 GenPept UniProtKB/Swiss-Prot:Q8R480

Gene LinkOut

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