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Rab44 RAB44, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 442827, updated on 11-Apr-2024

Summary

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Official Symbol
Rab44provided by MGI
Official Full Name
RAB44, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:3045302
See related
Ensembl:ENSMUSG00000064147 AllianceGenome:MGI:3045302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9830134C10Rik
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be located in plasma membrane. Orthologous to human RAB44 (RAB44, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 6.4), lung adult (RPKM 3.8) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 15.14 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29333102..29367966)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (29114128..29148980)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42251 Neighboring gene tumor protein p53 pathway corepressor 1 Neighboring gene predicted gene, 41556 Neighboring gene STARR-seq mESC enhancer starr_42255 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29218945-29219128 Neighboring gene STARR-seq mESC enhancer starr_42257 Neighboring gene STARR-seq mESC enhancer starr_42258 Neighboring gene STARR-positive B cell enhancer mm9_chr17:29239826-29240127 Neighboring gene cyclin dependent kinase inhibitor 1A Neighboring gene STARR-positive B cell enhancer mm9_chr17:29243389-29243689 Neighboring gene STARR-positive B cell enhancer mm9_chr17:29243839-29244139 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29255128-29255329 Neighboring gene STARR-seq mESC enhancer starr_42259 Neighboring gene ribosomal protein L35A, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_42262 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29301422-29301531 Neighboring gene somatostatin receptor 4 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8663 Neighboring gene copine V Neighboring gene STARR-positive B cell enhancer ABC_E10943 Neighboring gene STARR-seq mESC enhancer starr_42268

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rab44 Deficiency Induces Impaired Immune Responses to Nickel Allergy. Noguromi M, et al. Int J Mol Sci, 2023 Jan 4. PMID 36674510, Free PMC Article
  2. Large Rab GTPase Rab44 regulates microtubule-dependent retrograde melanosome transport in melanocytes. Maruta Y, et al. J Biol Chem, 2022 Nov. PMID 36126775, Free PMC Article
  3. The large GTPase Rab44 regulates granule exocytosis in mast cells and IgE-mediated anaphylaxis. Kadowaki T, et al. Cell Mol Immunol, 2020 Dec. PMID 32238914, Free PMC Article
  4. Rab44 regulates murine mast cell-driven anaphylaxis through kinesin-1-dependent secretory granule translocation. Longé C, et al. J Allergy Clin Immunol, 2022 Sep. PMID 35469841
  5. Rab44 isoforms similarly promote lysosomal exocytosis, but exhibit differential localization in mast cells. Kadowaki T, et al. FEBS Open Bio, 2021 Apr. PMID 33641252, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab44 Deficiency Induces Impaired Immune Responses to Nickel Allergy.
    Title: Rab44 Deficiency Induces Impaired Immune Responses to Nickel Allergy.
  2. Large Rab GTPase Rab44 regulates microtubule-dependent retrograde melanosome transport in melanocytes.
    Title: Large Rab GTPase Rab44 regulates microtubule-dependent retrograde melanosome transport in melanocytes.
  3. Rab44 regulates murine mast cell-driven anaphylaxis through kinesin-1-dependent secretory granule translocation.
    Title: Rab44 regulates murine mast cell-driven anaphylaxis through kinesin-1-dependent secretory granule translocation.
  4. Rab44 isoforms similarly promote lysosomal exocytosis, but exhibit differential localization in mast cells.
    Title: Rab44 isoforms similarly promote lysosomal exocytosis, but exhibit differential localization in mast cells.
  5. The large GTPase Rab44 regulates granule exocytosis in mast cells and IgE-mediated anaphylaxis.
    Title: The large GTPase Rab44 regulates granule exocytosis in mast cells and IgE-mediated anaphylaxis.
  6. Data show that Rab GTPase Rab44 affects nuclear factor of activated T-cells c1 (NFATc1) signaling in RANKL-stimulated macrophages.
    Title: Rab44, a novel large Rab GTPase, negatively regulates osteoclast differentiation by modulating intracellular calcium levels followed by NFATc1 activation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within histamine secretion by mast cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within histamine secretion mediated by IgE immunoglobulin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-related protein Rab-44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364848.1 → NP_001351777.1  ras-related protein Rab-44

    Status: VALIDATED

    Source sequence(s)
    AC167363, BY203725
    Consensus CDS
    CCDS37535.2
    UniProtKB/Swiss-Prot
    B9EID0, Q8CB87
    Related
    ENSMUSP00000156400.2, ENSMUST00000233717.2
    Conserved Domains (4) summary
    cd00154
    Location:788 → 944
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    PHA03247
    Location:425 → 783
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:173 → 353
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam13499
    Location:45 → 101
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    29333102..29367966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160678.1 → XP_036016571.1  ras-related protein Rab-44 isoform X2

    Conserved Domains (3) summary
    cd00154
    Location:788 → 910
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    COG1196
    Location:160 → 337
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam03154
    Location:422 → 745
    Atrophin-1; Atrophin-1 family

  2. XM_006524598.3 → XP_006524661.1  ras-related protein Rab-44 isoform X8

    Conserved Domains (3) summary
    cd00154
    Location:363 → 519
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    TIGR02168
    Location:161 → 341
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam13499
    Location:45 → 101
    EF-hand_7; EF-hand domain pair

  3. XM_006524593.3 → XP_006524656.1  ras-related protein Rab-44 isoform X3

    Conserved Domains (4) summary
    cd00154
    Location:739 → 895
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    PHA03247
    Location:376 → 734
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:178 → 304
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam13499
    Location:45 → 101
    EF-hand_7; EF-hand domain pair

  4. XM_006524595.1 → XP_006524658.1  ras-related protein Rab-44 isoform X5

    Conserved Domains (4) summary
    PHA03247
    Location:425 → 783
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:173 → 353
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam13499
    Location:45 → 101
    EF-hand_7; EF-hand domain pair
    cl38936
    Location:788 → 846
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. XM_011246529.2 → XP_011244831.1  ras-related protein Rab-44 isoform X1

    See identical proteins and their annotated locations for XP_011244831.1

    UniProtKB/Swiss-Prot
    B9EID0, Q8CB87
    Conserved Domains (4) summary
    cd00154
    Location:788 → 944
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    PHA03247
    Location:425 → 783
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:173 → 353
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam13499
    Location:45 → 101
    EF-hand_7; EF-hand domain pair

  6. XM_006524596.5 → XP_006524659.1  ras-related protein Rab-44 isoform X6

    Conserved Domains (3) summary
    cd00154
    Location:633 → 789
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    PHA03247
    Location:270 → 628
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:18 → 198
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  7. XM_006524594.3 → XP_006524657.1  ras-related protein Rab-44 isoform X4

    Conserved Domains (3) summary
    cd00154
    Location:706 → 862
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    PHA03247
    Location:343 → 701
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:91 → 271
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. XM_006524597.5 → XP_006524660.1  ras-related protein Rab-44 isoform X7

    See identical proteins and their annotated locations for XP_006524660.1

    UniProtKB/TrEMBL
    A0A2Y9CZI3
    Related
    ENSMUSP00000085253.5, ENSMUST00000087942.6
    Conserved Domains (3) summary
    cd00154
    Location:540 → 696
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    PHA03247
    Location:177 → 535
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:7 → 105
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001002786.2: Suppressed sequence

    Description
    NM_001002786.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CB87.2 GenPept UniProtKB/Swiss-Prot:Q8CB87

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