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MIR570HG MIR570 host gene [ Homo sapiens (human) ]

Gene ID: 440993, updated on 6-Nov-2023

Summary

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Official Symbol
MIR570HGprovided by HGNC
Official Full Name
MIR570 host geneprovided by HGNC
Primary source
HGNC:HGNC:53743
See related
AllianceGenome:HGNC:53743
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LINC00969
Expression
Ubiquitous expression in testis (RPKM 6.0), small intestine (RPKM 5.6) and 25 other tissues See more
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Genomic context

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Location:
3q29
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (195688498..195711875)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (198397911..198407978)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (195415369..195438746)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr3:195345772-195345926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195350846-195351842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195354448-195355072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195355073-195355695 Neighboring gene mucin 20, cell surface associated pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195359633-195360132 Neighboring gene uncharacterized LOC105374297 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195373516-195374016 Neighboring gene serine/threonine-protein phosphatase 4 regulatory subunit 2-like Neighboring gene SDHA pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195408429-195408928 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195410251-195410972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195410973-195411692 Neighboring gene uncharacterized LOC124909477 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:195431923-195432494 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195437307-195437978 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195437979-195438649 Neighboring gene microRNA 570 Neighboring gene somatomedin B domain containing 1, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195453109-195453610 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195461991-195462491 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195466177-195466985 Neighboring gene mucin 20, cell surface associated Neighboring gene ReSE screen-validated silencer GRCh37_chr3:195474413-195474579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195489021-195489522 Neighboring gene mucin 4, cell surface associated Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195495435-195495936 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:195505212-195506411 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195508163-195508662 Neighboring gene Sharpr-MPRA regulatory region 430 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195533677-195534240 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195535933-195536496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195536497-195537060

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LINC00969 promotes the degeneration of intervertebral disk by sponging miR-335-3p and regulating NLRP3 inflammasome activation. Yu L, et al. IUBMB Life, 2019 May. PMID 30592131
  2. Identification of long noncoding RNAs for the detection of early stage lung squamous cell carcinoma by microarray analysis. Cheng Z, et al. Oncotarget, 2017 Feb 21. PMID 28076325, Free PMC Article
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Corominas R, et al. Nat Commun, 2014 Apr 11. PMID 24722188, Free PMC Article
  4. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Dias Neto E, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737800, Free PMC Article
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, et al. BMC Biol, 2017 Nov 8. PMID 29117863, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exosomal Linc00969 induces trastuzumab resistance in breast cancer by increasing HER-2 protein expression and mRNA stability by binding to HUR.
    Title: Exosomal Linc00969 induces trastuzumab resistance in breast cancer by increasing HER-2 protein expression and mRNA stability by binding to HUR.
  2. High LINC00969 expression is associated with degeneration of intervertebral disk.
    Title: LINC00969 promotes the degeneration of intervertebral disk by sponging miR-335-3p and regulating NLRP3 inflammasome activation.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • long intergenic non-protein coding RNA 969

Clone Names

  • AC069513.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_122105.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC233280

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    195688498..195711875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187532.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    58995..82372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187649.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    81285..103902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_187678.1 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    84169..107546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_187688.1 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    81492..104464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_187689.1 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    58995..82372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_187690.1 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    81799..105176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NT_187691.1 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    82066..106613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    198397911..198407978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013714.1: Suppressed sequence

    Description
    NM_001013714.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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