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LINC01123 long intergenic non-protein coding RNA 1123 [ Homo sapiens (human) ]

Gene ID: 440894, updated on 25-Dec-2023

Summary

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Official Symbol
LINC01123provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 1123provided by HGNC
Primary source
HGNC:HGNC:49269
See related
Ensembl:ENSG00000204588 AllianceGenome:HGNC:49269
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in brain (RPKM 18.1), duodenum (RPKM 15.3) and 22 other tissues See more
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Genomic context

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Location:
2q13
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (109986980..109995281)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (110409236..110417561)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (110744557..110752858)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene LIMS3-LOC440895 readthrough Neighboring gene two pore channel 3 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:110738405-110738906 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:110738907-110739406 Neighboring gene glycosylphosphatidylinositol anchor attachment 1 pseudogene 1 Neighboring gene zinc finger and BTB domain containing 45 pseudogene 1 Neighboring gene zinc finger protein 532 pseudogene Neighboring gene uncharacterized LOC112268438 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:110781467-110782104 Neighboring gene platelet endothelial aggregation receptor 1-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:110782940-110783824

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Long non-coding RNA LINC01123 promotes cell proliferation, migration and invasion via interacting with SRSF7 in colorectal cancer. Liu Z, et al. Pathol Res Pract, 2022 Apr. PMID 35325644
  2. Knockdown of LINC01123 inhibits cell viability, migration and invasion via miR-361-3p/TSPAN1 targeting in cervical cancer. Li C, et al. Exp Ther Med, 2021 Oct. PMID 34475974, Free PMC Article
  3. LINC01123 facilitates proliferation, invasion and chemoresistance of colon cancer cells. Ye S, et al. Biosci Rep, 2020 Aug 28. PMID 32700743, Free PMC Article
  4. LINC01123 is associated with prognosis of oral squamous cell carcinoma and involved in tumor progression by sponging miR-34a-5p. Qin H, et al. Oral Surg Oral Med Oral Pathol Oral Radiol, 2022 Jan. PMID 34511356
  5. ZEB1-activated LINC01123 accelerates the malignancy in lung adenocarcinoma through NOTCH signaling pathway. Zhang M, et al. Cell Death Dis, 2020 Nov 15. PMID 33191397, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LINC01123 acts as an oncogenic driver in lung adenocarcinoma by regulating the miR-4766-5p/PYCR1 axis.
    Title: LINC01123 acts as an oncogenic driver in lung adenocarcinoma by regulating the miR-4766-5p/PYCR1 axis.
  2. Long non-coding RNA LINC01123 promotes cell proliferation, migration and invasion via interacting with SRSF7 in colorectal cancer.
    Title: Long non-coding RNA LINC01123 promotes cell proliferation, migration and invasion via interacting with SRSF7 in colorectal cancer.
  3. LINC01123 promotes immune escape by sponging miR-214-3p to regulate B7-H3 in head and neck squamous-cell carcinoma.
    Title: LINC01123 promotes immune escape by sponging miR-214-3p to regulate B7-H3 in head and neck squamous-cell carcinoma.
  4. LINC01123 is associated with prognosis of oral squamous cell carcinoma and involved in tumor progression by sponging miR-34a-5p.
    Title: LINC01123 is associated with prognosis of oral squamous cell carcinoma and involved in tumor progression by sponging miR-34a-5p.
  5. LINC01123 potentially correlates with radioresistance in glioma through the miR-151a/CENPB axis.
    Title: LINC01123 potentially correlates with radioresistance in glioma through the miR-151a/CENPB axis.
  6. LINC01123 promotes cell proliferation and migration via regulating miR-1277-5p/KLF5 axis in ox-LDL-induced vascular smooth muscle cells.
    Title: LINC01123 promotes cell proliferation and migration via regulating miR-1277-5p/KLF5 axis in ox-LDL-induced vascular smooth muscle cells.
  7. LINC01123 enhances osteosarcoma cell growth by activating the Hedgehog pathway via the miR-516b-5p/Gli1 axis.
    Title: LINC01123 enhances osteosarcoma cell growth by activating the Hedgehog pathway via the miR-516b-5p/Gli1 axis.
  8. ZEB1-activated LINC01123 accelerates the malignancy in lung adenocarcinoma through NOTCH signaling pathway.
    Title: ZEB1-activated LINC01123 accelerates the malignancy in lung adenocarcinoma through NOTCH signaling pathway.
  9. LINC01123 facilitates proliferation, invasion and chemoresistance of colon cancer cells.
    Title: LINC01123 facilitates proliferation, invasion and chemoresistance of colon cancer cells.
  10. Functional assays showed that LINC01123 promoted NSCLC cell proliferation and aerobic glycolysis. Mechanistic investigations revealed that LINC01123 was a direct transcriptional target of c-Myc. LINC01123 increased c-Myc mRNA expression by sponging miR-199a-5p.
    Title: LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Clone Names

  • AC013268.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_046110.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AC013268, AK056084, BC101448, BP247062
    Related
    ENST00000419296.1

  2. NR_046111.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 3' exon, compared to variant 1.
    Source sequence(s)
    AC013268, AK056084, BC101448, BP247062

  3. NR_046112.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate internal exons, compared to variant 1.
    Source sequence(s)
    AC013268, AK056084, BP247062, DA999847

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    109986980..109995281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    110409236..110417561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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