U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CIMAP1B ciliary microtubule associated protein 1B [ Homo sapiens (human) ]

Gene ID: 440836, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
CIMAP1Bprovided by HGNC
Official Full Name
ciliary microtubule associated protein 1Bprovided by HGNC
Primary source
HGNC:HGNC:34388
See related
Ensembl:ENSG00000177989 AllianceGenome:HGNC:34388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ODF3B; FAP123; ODF3L3
Summary
Predicted to be active in cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung (RPKM 15.4), spleen (RPKM 12.9) and 22 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CIMAP1B in Genome Data Viewer
Location:
22q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50530426..50532498, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (51040987..51043059, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50968855..50970927, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13984 Neighboring gene non-SMC condensin II complex subunit H2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50955745-50956678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50965237-50965808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19324 Neighboring gene synthesis of cytochrome C oxidase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19325 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13988 Neighboring gene thymidine phosphorylase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13989 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50969361-50969866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19326 Neighboring gene ODF3B-KLHDC7B intergenic CAGE-defined mid-level expression enhancer Neighboring gene uncharacterized LOC102724608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19329 Neighboring gene Sharpr-MPRA regulatory region 5393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19330 Neighboring gene KLHDC7B divergent transcript Neighboring gene Sharpr-MPRA regulatory region 13947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13995 Neighboring gene kelch domain containing 7B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13996

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structural properties of 3.0 kb and 3.2 kb transcripts encoding platelet-derived endothelial cell growth factor/thymidine phosphorylase in A431 cells. Usuki K, et al. Biochim Biophys Acta, 1994 Jul 21. PMID 8038210
  2. AirID, a novel proximity biotinylation enzyme, for analysis of protein-protein interactions. Kido K, et al. Elife, 2020 May 11. PMID 32391793, Free PMC Article
  3. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Ganesh SK, et al. Nat Genet, 2009 Nov. PMID 19862010, Free PMC Article
  4. Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107413
  5. Seventy-five genetic loci influencing the human red blood cell. van der Harst P, et al. Nature, 2012 Dec 20. PMID 23222517, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Seventy-five genetic loci influencing the human red blood cell.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ciliary microtubule associated protein 1B
Names
orf2 5' to PD-ECGF/TP
outer dense fiber of sperm tails 3B
outer dense fiber protein 3-like protein 3
outer dense fiber protein 3B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014440.4 → NP_001014440.2  ciliary microtubule associated protein 1B isoform 3

    See identical proteins and their annotated locations for NP_001014440.2

    Status: VALIDATED

    Source sequence(s)
    AW291097, BC127935, BG149596
    Consensus CDS
    CCDS43039.1
    UniProtKB/Swiss-Prot
    A0PK18, A8MYP8
    Related
    ENSP00000382804.2, ENST00000329363.9

  2. NM_001382807.1 → NP_001369736.1  ciliary microtubule associated protein 1B isoform 2

    Status: VALIDATED

    Source sequence(s)
    U62317
    Consensus CDS
    CCDS93189.1
    UniProtKB/TrEMBL
    B5MD02
    Related
    ENSP00000384310.1, ENST00000401779.5

  3. NM_001382808.1 → NP_001369737.1  ciliary microtubule associated protein 1B isoform 1

    Status: VALIDATED

    Source sequence(s)
    U62317
    Consensus CDS
    CCDS93190.1
    UniProtKB/TrEMBL
    A0A8C8KQ56
    Related
    ENSP00000390712.3, ENST00000428989.3

  4. NM_001410791.1 → NP_001397720.1  ciliary microtubule associated protein 1B isoform 4

    Status: VALIDATED

    Source sequence(s)
    U62317
    Consensus CDS
    CCDS93188.1
    UniProtKB/TrEMBL
    B5MC17
    Related
    ENSP00000385123.1, ENST00000403326.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    50530426..50532498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441379.1 → XP_047297335.1  ciliary microtubule associated protein 1B isoform X1

  2. XM_047441378.1 → XP_047297334.1  ciliary microtubule associated protein 1B isoform X1

  3. XM_047441382.1 → XP_047297338.1  ciliary microtubule associated protein 1B isoform X4

  4. XM_047441381.1 → XP_047297337.1  ciliary microtubule associated protein 1B isoform X3

  5. XM_047441380.1 → XP_047297336.1  ciliary microtubule associated protein 1B isoform X2

    UniProtKB/Swiss-Prot
    A0PK18, A8MYP8
    Related
    ENSP00000507825.1, ENST00000682240.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    51040987..51043059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325645.1 → XP_054181620.1  ciliary microtubule associated protein 1B isoform X1

  2. XM_054325644.1 → XP_054181619.1  ciliary microtubule associated protein 1B isoform X1

  3. XM_054325648.1 → XP_054181623.1  ciliary microtubule associated protein 1B isoform X4

  4. XM_054325647.1 → XP_054181622.1  ciliary microtubule associated protein 1B isoform X3

  5. XM_054325646.1 → XP_054181621.1  ciliary microtubule associated protein 1B isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MYP8.1 GenPept UniProtKB/Swiss-Prot:A8MYP8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous