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ZNF724 zinc finger protein 724 [ Homo sapiens (human) ]

Gene ID: 440519, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF724provided by HGNC
Official Full Name
zinc finger protein 724provided by HGNC
Primary source
HGNC:HGNC:32460
See related
Ensembl:ENSG00000196081 AllianceGenome:HGNC:32460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF724P
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See ZNF724 in Genome Data Viewer
Location:
19p12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (23221599..23250394, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (23356434..23385220, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (23404401..23433196, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 730 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene BCL2 interacting protein 3 pseudogene 37 Neighboring gene sorting nexin 6 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:23343199-23343774 Neighboring gene MPRA-validated peak3415 silencer Neighboring gene BCL2 interacting protein 3 pseudogene 38 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14391 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10459 Neighboring gene importin 5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10460 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10461 Neighboring gene vomeronasal 1 receptor 90 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout. Kawamura Y, et al. Ann Rheum Dis, 2019 Oct. PMID 31289104, Free PMC Article
  2. N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective. Jonckheere V, et al. Int J Mol Sci, 2021 Apr 1. PMID 33916271, Free PMC Article
  3. Human transcription factor protein interaction networks. Göös H, et al. Nat Commun, 2022 Feb 9. PMID 35140242, Free PMC Article
  4. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Liu X, et al. Nat Commun, 2018 Mar 22. PMID 29568061, Free PMC Article
  5. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 724

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355404.2 → NP_001342333.1  zinc finger protein 724 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC092329
    Consensus CDS
    CCDS86737.1
    UniProtKB/Swiss-Prot
    A8MTY0, B4DVU0
    Related
    ENSP00000413411.2, ENST00000418100.6
    Conserved Domains (5) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:143 → 526
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:530 → 610
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:340 → 360
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:548 → 572
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001355405.2 → NP_001342334.1  zinc finger protein 724 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092329
    Conserved Domains (3) summary
    COG5048
    Location:79 → 462
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:276 → 296
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:484 → 508
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001355406.2 → NP_001342335.1  zinc finger protein 724 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092329
    Conserved Domains (5) summary
    smart00349
    Location:2 → 58
    KRAB; krueppel associated box
    COG5048
    Location:137 → 520
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:524 → 604
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:334 → 354
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:542 → 566
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    23221599..23250394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451520.2 → XP_024307288.1  zinc finger protein 724 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:79 → 462
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:276 → 296
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:484 → 508
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    23356434..23385220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321048.1 → XP_054177023.1  zinc finger protein 724 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_005791.3: Suppressed sequence

    Description
    NG_005791.3: This RefSeq was permanently suppressed because it is now thought that this gene is a transcribed pseudogene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MTY0.3 GenPept UniProtKB/Swiss-Prot:A8MTY0

Gene LinkOut

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