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ZNF705A zinc finger protein 705A [ Homo sapiens (human) ]

Gene ID: 440077, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF705Aprovided by HGNC
Official Full Name
zinc finger protein 705Aprovided by HGNC
Primary source
HGNC:HGNC:32281
See related
Ensembl:ENSG00000196946 AllianceGenome:HGNC:32281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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Location:
12p13.31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (8157015..8180046)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (8170619..8193651)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (8309611..8332642)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 4 member A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:8286281-8287059 Neighboring gene POU class 5 homeobox 1 pseudogene 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:8294369-8294870 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:8296489-8296988 Neighboring gene GCSH pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:8333169-8333668 Neighboring gene family with sequence similarity 66 member C Neighboring gene defensin beta 109F (pseudogene) Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:8375857-8377056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5931 Neighboring gene family with sequence similarity 90 member A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Clone Names

  • FLJ16353

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 705A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004328.3 → NP_001004328.1  zinc finger protein 705A

    See identical proteins and their annotated locations for NP_001004328.1

    Status: VALIDATED

    Source sequence(s)
    AC092111
    Consensus CDS
    CCDS31737.1
    UniProtKB/Swiss-Prot
    Q6ZN79
    Related
    ENSP00000379816.4, ENST00000396570.8
    Conserved Domains (5) summary
    smart00349
    Location:7 → 66
    KRAB; krueppel associated box
    COG5048
    Location:121 → 300
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:174 → 194
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 46
    KRAB; KRAB box
    pfam13465
    Location:214 → 239
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    8157015..8180046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    8170619..8193651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZN79.1 GenPept UniProtKB/Swiss-Prot:Q6ZN79

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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