U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

apolpp apolipophorin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43827, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
apolppprovided by FlyBase
Official Full Name
apolipophorinprovided by FlyBase
Primary source
FLYBASE:FBgn0087002
Locus tag
Dmel_CG11064
See related
AllianceGenome:FB:FBgn0087002
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ApoL1; ApoL2; apoLI; ApoLI; apoLII; ApoLII; apoLpp; apoLPP; Apolpp; ApoLpp; CG11064; chr4:1088013..1088173; Dmel\CG11064; DRBP; lipophorin; Lipophorin; Lpp; LPP; rfabg; Rfabg; RFABG; Rfabp; RfaBp; RfaBP; RFABP; RFBP; T3
Summary
Enables several functions, including heme binding activity; microtubule binding activity; and retinol binding activity. Involved in lipid transport involved in lipid storage; lipoprotein transport; and positive regulation of signal transduction. Located in basal part of cell; endocytic vesicle; and extracellular space. Is expressed in several structures, including amnioserosa; circulatory system; embryonic/larval central nervous system; fat body; and spermatozoon. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
102F7-102F8; 4-0 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (1060969..1077273)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (1081595..1097899)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene ATP synthase, beta subunit Neighboring gene uncharacterized protein Neighboring gene Calcium/calmodulin-dependent protein kinase II Neighboring gene Zyxin Neighboring gene Activin-beta Neighboring gene shaven Neighboring gene Calsyntenin

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Early life exercise training and inhibition of apoLpp mRNA expression to improve age-related arrhythmias and prolong the average lifespan in Drosophila melanogaster. Ding M, et al. Aging (Albany NY), 2022 Dec 5. PMID 36470666, Free PMC Article
  2. Effects of Drosophila melanogaster regular exercise and apolipoprotein B knockdown on abnormal heart rhythm induced by a high-fat diet. Ding M, et al. PLoS One, 2022. PMID 35657779, Free PMC Article
  3. Exercise-Training Regulates Apolipoprotein B in Drosophila to Improve HFD-Mediated Cardiac Function Damage and Low Exercise Capacity. Ding M, et al. Front Physiol, 2021. PMID 34305631, Free PMC Article
  4. The Role of Lipid Competition for Endosymbiont-Mediated Protection against Parasitoid Wasps in Drosophila. Paredes JC, et al. mBio, 2016 Jul 12. PMID 27406568, Free PMC Article
  5. Insect endosymbiont proliferation is limited by lipid availability. Herren JK, et al. Elife, 2014 Jul 15. PMID 25027439, Free PMC Article

See all (160) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Early life exercise training and inhibition of apoLpp mRNA expression to improve age-related arrhythmias and prolong the average lifespan in Drosophila melanogaster.
    Title: Early life exercise training and inhibition of apoLpp mRNA expression to improve age-related arrhythmias and prolong the average lifespan in Drosophila melanogaster.
  2. Wingless, Hedgehog and glycophosphatidylinositol-linked proteins copurify with lipophorin, and co-localize with it in the developing wing epithelium of Drosophila.
    Title: Lipoprotein particles are required for Hedgehog and Wingless signalling.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

mobile_element

  • Loc: 1061502-1061989 mobile_element_type = transposon:INE-1{}3410

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables fatty acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables lipid transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables retinol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid transport involved in lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in basal part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
apolipophorin
Names
CG11064-PA
CG11064-PB
CG11064-PC
CG11064-PD
Retinoid- and fatty acid-binding glycoprotein
Retinoid- and fatty acid-binding protein
Retinoid- and fatty-acid binding protein
Retinoid-fatty acid-binding glycoprotein
RfaBp
apolipophorin I
apolipophorin II
apolipophorin-2
apolpp-PA
apolpp-PB
apolpp-PC
apolpp-PD
lipophorin
retinoid and fatty acid binding glycoprotein
retinoid and fatty acid binding protein
retinoid and fatty-acid binding protein
retinoid- and fatty acid-binding gene
retinoid-fatty acid binding protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    1060969..1077273
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297791.1 → NP_001284720.1  apolipophorin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284720.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8ST55, Q8T6S6, Q94907, Q9V496
    UniProtKB/TrEMBL
    L0MPS3
    Conserved Domains (4) summary
    smart00216
    Location:2789 → 2931
    VWD; von Willebrand factor (vWF) type D domain
    pfam01347
    Location:43 → 573
    Vitellogenin_N; Lipoprotein amino terminal region
    pfam06448
    Location:932 → 1031
    DUF1081; Domain of Unknown Function (DUF1081)
    pfam09172
    Location:605 → 911
    DUF1943; Domain of unknown function (DUF1943)

  2. NM_001297792.1 → NP_001284721.1  apolipophorin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284721.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8ST55, Q8T6S6, Q94907, Q9V496
    UniProtKB/TrEMBL
    L0MPS3
    Conserved Domains (4) summary
    smart00216
    Location:2789 → 2931
    VWD; von Willebrand factor (vWF) type D domain
    pfam01347
    Location:43 → 573
    Vitellogenin_N; Lipoprotein amino terminal region
    pfam06448
    Location:932 → 1031
    DUF1081; Domain of Unknown Function (DUF1081)
    pfam09172
    Location:605 → 911
    DUF1943; Domain of unknown function (DUF1943)

  3. NM_001272156.1 → NP_001259085.1  apolipophorin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259085.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8ST55, Q8T6S6, Q94907, Q9V496
    UniProtKB/TrEMBL
    L0MPS3
    Conserved Domains (4) summary
    smart00216
    Location:2789 → 2931
    VWD; von Willebrand factor (vWF) type D domain
    pfam01347
    Location:43 → 573
    Vitellogenin_N; Lipoprotein amino terminal region
    pfam06448
    Location:932 → 1031
    DUF1081; Domain of Unknown Function (DUF1081)
    pfam09172
    Location:605 → 911
    DUF1943; Domain of unknown function (DUF1943)

  4. NM_079895.3 → NP_524634.2  apolipophorin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524634.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8ST55, Q8T6S6, Q94907, Q9V496
    UniProtKB/TrEMBL
    L0MPS3
    Related
    FBpp0088252
    Conserved Domains (4) summary
    smart00216
    Location:2789 → 2931
    VWD; von Willebrand factor (vWF) type D domain
    pfam01347
    Location:43 → 573
    Vitellogenin_N; Lipoprotein amino terminal region
    pfam06448
    Location:932 → 1031
    DUF1081; Domain of Unknown Function (DUF1081)
    pfam09172
    Location:605 → 911
    DUF1943; Domain of unknown function (DUF1943)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
L0MPS3 L0MPS3
Q9V496.2 Q9V496

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous