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Pur-alpha Purine-rich binding protein-alpha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43797, updated on 11-Apr-2024

Summary

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Official Symbol
Pur-alphaprovided by FlyBase
Official Full Name
Purine-rich binding protein-alphaprovided by FlyBase
Primary source
FLYBASE:FBgn0022361
Locus tag
Dmel_CG1507
See related
AllianceGenome:FB:FBgn0022361
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1507; Dmel\CG1507; dPur alpha; Pur alpha; Pur-a; pur-alpha; purA; Puralpha; PURalpha
Summary
Enables mRNA binding activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of messenger ribonucleoprotein complex. Is expressed in several structures, including adult head and egg chamber. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 31. Orthologous to several human genes including PURB (purine rich element binding protein B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
102C5-102C5; 4-0 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (558016..567257)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (578642..587883)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene Zn finger homeodomain 2 Neighboring gene Thymine DNA glycosylase Neighboring gene long non-coding RNA:CR43958 Neighboring gene NADH dehydrogenase (ubiquinone) 49 kDa subunit Neighboring gene ephrin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha. Weber J, et al. Elife, 2016 Jan 8. PMID 26744780, Free PMC Article
  2. Pur-alpha functionally interacts with FUS carrying ALS-associated mutations. Di Salvio M, et al. Cell Death Dis, 2015 Oct 22. PMID 26492376, Free PMC Article
  3. Of bits and bugs--on the use of bioinformatics and a bacterial crystal structure to solve a eukaryotic repeat-protein structure. Graebsch A, et al. PLoS One, 2010 Oct 14. PMID 20976240, Free PMC Article
  4. X-ray structure of Pur-alpha reveals a Whirly-like fold and an unusual nucleic-acid binding surface. Graebsch A, et al. Proc Natl Acad Sci U S A, 2009 Nov 3. PMID 19846792, Free PMC Article
  5. Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration. Xu Z, et al. Proc Natl Acad Sci U S A, 2013 May 7. PMID 23553836, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The crystal structure reveals base-specific DNA recognition and offers a molecular explanation for the effect of point mutations in the 5q31.3 microdeletion syndrome.
    Title: Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha.
  2. The mRNA target spectrum of Pur-alpha is broader than previously anticipated, binding of trinucleotide repeat sequences in vitro and in vivo.
    Title: Drosophila Pur-α binds to trinucleotide-repeat containing cellular RNAs and translocates to the early oocyte.
  3. x-ray structure of residues 40 to 185 from Drosophila melanogaster Pur-alpha, which constitutes a major part of the core region
    Title: X-ray structure of Pur-alpha reveals a Whirly-like fold and an unusual nucleic-acid binding surface.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 565178-565220 mobile_element_type = transposon:INE-1{}6116

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables purine-rich negative regulatory element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables purine-rich negative regulatory element binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Purine-rich binding protein-alpha
Names
CG1507-PA
CG1507-PB
CG1507-PC
CG1507-PD
CG1507-PE
CG1507-PF
CG1507-PG
Pur-alpha-PA
Pur-alpha-PB
Pur-alpha-PC
Pur-alpha-PD
Pur-alpha-PE
Pur-alpha-PF
Pur-alpha-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    558016..567257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079885.2 → NP_524624.1  Purine-rich binding protein-alpha, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524624.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16860, Q9V4D9
    Related
    FBpp0089038
    Conserved Domains (1) summary
    pfam04845
    Location:41 → 254
    PurA; PurA ssDNA and RNA-binding protein

  2. NM_166767.2 → NP_726579.1  Purine-rich binding protein-alpha, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726579.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16860, Q95RR6
    Related
    FBpp0089039
    Conserved Domains (1) summary
    pfam04845
    Location:41 → 253
    PurA; PurA ssDNA and RNA-binding protein

  3. NM_166769.2 → NP_726581.1  Purine-rich binding protein-alpha, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726581.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16860, Q8IMC4
    Related
    FBpp0089036
    Conserved Domains (2) summary
    smart00712
    Location:28 → 90
    PUR; DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria
    pfam04845
    Location:26 → 239
    PurA; PurA ssDNA and RNA-binding protein

  4. NM_001272134.1 → NP_001259063.1  Purine-rich binding protein-alpha, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259063.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3YDK4, O16860
    Conserved Domains (2) summary
    smart00712
    Location:28 → 90
    PUR; DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria
    pfam04845
    Location:26 → 238
    PurA; PurA ssDNA and RNA-binding protein

  5. NM_166768.2 → NP_726580.1  Purine-rich binding protein-alpha, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726580.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16860, Q95RR6
    Related
    FBpp0089037
    Conserved Domains (1) summary
    pfam04845
    Location:41 → 253
    PurA; PurA ssDNA and RNA-binding protein

  6. NM_001272133.1 → NP_001259062.1  Purine-rich binding protein-alpha, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259062.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16860, Q9V4D9
    Conserved Domains (1) summary
    pfam04845
    Location:41 → 254
    PurA; PurA ssDNA and RNA-binding protein

  7. NM_001272132.1 → NP_001259061.1  Purine-rich binding protein-alpha, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259061.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16860, Q95RR6
    Conserved Domains (1) summary
    pfam04845
    Location:41 → 253
    PurA; PurA ssDNA and RNA-binding protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F3YDK4 F3YDK4
O16860 O16860
Q8IMC4 Q8IMC4
Q95RR6 Q95RR6
Q9V4D9 Q9V4D9

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