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Tnni3k TNNI3 interacting kinase [ Mus musculus (house mouse) ]

Gene ID: 435766, updated on 11-Apr-2024

Summary

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Official Symbol
Tnni3kprovided by MGI
Official Full Name
TNNI3 interacting kinaseprovided by MGI
Primary source
MGI:MGI:2443276
See related
Ensembl:ENSMUSG00000040086 AllianceGenome:MGI:2443276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cark; D830019J24Rik
Summary
Predicted to enable protein C-terminus binding activity; protein serine/threonine kinase activity; and troponin I binding activity. Involved in regulation of cardiac conduction and regulation of heart rate. Predicted to be located in cytoplasm and nucleus. Orthologous to several human genes including FPGT-TNNI3K (FPGT-TNNI3K readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward heart adult (RPKM 27.2) See more
Orthologs
human all
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Genomic context

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Location:
3 H4; 3 79.32 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (154491928..154761044, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (154786291..155055407, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9581 Neighboring gene STARR-seq mESC enhancer starr_09341 Neighboring gene tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E4607 Neighboring gene STARR-seq mESC enhancer starr_09345 Neighboring gene crystallin, zeta Neighboring gene STARR-seq mESC enhancer starr_09346 Neighboring gene predicted gene 20389 Neighboring gene glutamate rich 3 Neighboring gene STARR-seq mESC enhancer starr_09349 Neighboring gene leucine rich repeat containing 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09350 Neighboring gene STARR-seq mESC enhancer starr_09351 Neighboring gene STARR-seq mESC enhancer starr_09352 Neighboring gene STARR-seq mESC enhancer starr_09353 Neighboring gene STARR-positive B cell enhancer ABC_E7951 Neighboring gene leucine-rich repeats and IQ motif containing 3 Neighboring gene fucose-1-phosphate guanylyltransferase Neighboring gene STARR-seq mESC enhancer starr_09354

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cardiac Troponin I-Interacting Kinase Affects Cardiomyocyte S-Phase Activity but Not Cardiomyocyte Proliferation. Reuter SP, et al. Circulation, 2023 Jan 10. PMID 36382596, Free PMC Article
  2. The prevalent I686T human variant and loss-of-function mutations in the cardiomyocyte-specific kinase gene TNNI3K cause adverse contractility and concentric remodeling in mice. Gan P, et al. Hum Mol Genet, 2021 Jan 6. PMID 33084860, Free PMC Article
  3. TNNI3K in cardiovascular disease and prospects for therapy. Milano A, et al. J Mol Cell Cardiol, 2015 May. PMID 25787061
  4. Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds. Swift SK, et al. Development, 2023 Apr 1. PMID 36912240, Free PMC Article
  5. Tnni3k alleles influence ventricular mononuclear diploid cardiomyocyte frequency. Gan P, et al. PLoS Genet, 2019 Oct. PMID 31589606, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tnni3k influences cardiomyocyte S-phase activity and proliferation.
    Title: Tnni3k influences cardiomyocyte S-phase activity and proliferation.
  2. An improved method reveals the dual role of Tnni3k in promoting S-phase entry while suppressing cell division in cardiomyocytes.
    Title: An improved method reveals the dual role of Tnni3k in promoting S-phase entry while suppressing cell division in cardiomyocytes.
  3. Expression Levels of the Tnni3k Gene in the Heart Are Highly Associated with Cardiac and Glucose Metabolism-Related Phenotypes and Functional Pathways.
    Title: Expression Levels of the Tnni3k Gene in the Heart Are Highly Associated with Cardiac and Glucose Metabolism-Related Phenotypes and Functional Pathways.
  4. Cardiac Troponin I-Interacting Kinase Affects Cardiomyocyte S-Phase Activity but Not Cardiomyocyte Proliferation.
    Title: Cardiac Troponin I-Interacting Kinase Affects Cardiomyocyte S-Phase Activity but Not Cardiomyocyte Proliferation.
  5. The prevalent I686T human variant and loss-of-function mutations in the cardiomyocyte-specific kinase gene TNNI3K cause adverse contractility and concentric remodeling in mice.
    Title: The prevalent I686T human variant and loss-of-function mutations in the cardiomyocyte-specific kinase gene TNNI3K cause adverse contractility and concentric remodeling in mice.
  6. This may be explained by the observation that Tnni3k function in mice converges with oxidative stress to regulate mononuclear diploid cardiomyocyte frequency.
    Title: Tnni3k alleles influence ventricular mononuclear diploid cardiomyocyte frequency.
  7. using novel genetic animal models and newly developed small-molecule TNNI3K inhibitors, we demonstrated that TNNI3K-mediated IR injury occurs through impaired mitochondrial function and is in part dependent on p38 MAPK.
    Title: Troponin I-interacting protein kinase: a novel cardiac-specific kinase, emerging as a molecular target for the treatment of cardiac disease.
  8. Our data provide the first evidence for a role of Tnni3k in controlling the electrocardiographic PR interval indicating a function of Tnni3k in atrio-ventricular conduction
    Title: Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction.
  9. Data identified Tnni3k, Fpgt and H28 as likely likely candidates for Vms1.
    Title: Quantitative trait locus analysis, pathway analysis, and consomic mapping show genetic variants of Tnni3k, Fpgt, or H28 control susceptibility to viral myocarditis.
  10. Tnni3k plays a critical role in the modulation of different forms of heart disease, and this protein may provide a novel target for therapeutic intervention.
    Title: Tnni3k modifies disease progression in murine models of cardiomyopathy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cardiac conduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase TNNI3K
Names
cardiac ankyrin repeat kinase
NP_796040.3
XP_011238456.1
XP_011238457.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177066.5 → NP_796040.3  serine/threonine-protein kinase TNNI3K

    See identical proteins and their annotated locations for NP_796040.3

    Status: VALIDATED

    Source sequence(s)
    AC124174, AC125097, AC144762, BY452372
    Consensus CDS
    CCDS17928.1
    UniProtKB/Swiss-Prot
    B2RTJ7, Q5GIG5, Q5GIG6
    Related
    ENSMUSP00000070561.4, ENSMUST00000064076.6
    Conserved Domains (6) summary
    smart00219
    Location:462 → 718
    TyrKc; Tyrosine kinase, catalytic domain
    cd00204
    Location:99 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14064
    Location:468 → 721
    PKc_TNNI3K; Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase
    pfam12796
    Location:138 → 231
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:339 → 400
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:134 → 164
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    154491928..154761044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240155.1 → XP_011238457.1  serine/threonine-protein kinase TNNI3K isoform X1

    See identical proteins and their annotated locations for XP_011238457.1

    Related
    ENSMUSP00000122478.2, ENSMUST00000143410.7
    Conserved Domains (4) summary
    PTZ00322
    Location:2 → 156
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA03095
    Location:113 → 413
    PHA03095; ankyrin-like protein; Provisional
    cd14064
    Location:468 → 706
    PKc_TNNI3K; Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase
    sd00045
    Location:134 → 164
    ANK; ANK repeat [structural motif]

  2. XM_011240154.1 → XP_011238456.1  serine/threonine-protein kinase TNNI3K isoform X1

    See identical proteins and their annotated locations for XP_011238456.1

    Conserved Domains (4) summary
    PTZ00322
    Location:2 → 156
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA03095
    Location:113 → 413
    PHA03095; ankyrin-like protein; Provisional
    cd14064
    Location:468 → 706
    PKc_TNNI3K; Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase
    sd00045
    Location:134 → 164
    ANK; ANK repeat [structural motif]

RNA

  1. XR_375539.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001012364.1: Suppressed sequence

    Description
    NM_001012364.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5GIG6.4 GenPept UniProtKB/Swiss-Prot:Q5GIG6

Gene LinkOut

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