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Shf Src homology 2 domain containing F [ Mus musculus (house mouse) ]

Gene ID: 435684, updated on 5-Mar-2024

Summary

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Official Symbol
Shfprovided by MGI
Official Full Name
Src homology 2 domain containing Fprovided by MGI
Primary source
MGI:MGI:3613669
See related
Ensembl:ENSMUSG00000033256 AllianceGenome:MGI:3613669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable phosphotyrosine residue binding activity. Predicted to act upstream of or within apoptotic process. Is expressed in several structures, including endocrine gland; large intestine; male reproductive gland or organ; nervous system; and trachea. Orthologous to human SHF (Src homology 2 domain containing F). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 11.0), whole brain E14.5 (RPKM 2.7) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E5; 2 60.63 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (122179373..122199650, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122348892..122369147, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dual oxidase maturation factor 2 Neighboring gene dual oxidase maturation factor 1 Neighboring gene dual oxidase 1 Neighboring gene STARR-seq mESC enhancer starr_05553 Neighboring gene STARR-positive B cell enhancer ABC_E10134 Neighboring gene STARR-seq mESC enhancer starr_05555 Neighboring gene STARR-positive B cell enhancer ABC_E1253 Neighboring gene STARR-positive B cell enhancer ABC_E7854 Neighboring gene nuclear encoded tRNA histidine 4 (anticodon GTG) Neighboring gene predicted gene, 39918 Neighboring gene nuclear encoded tRNA histidine 3 (anticodon GTG)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer's disease. Yamaguchi-Kabata Y, et al. Hum Genet, 2018 Jul. PMID 30006735, Free PMC Article
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results, obtained from the integrative approach, suggest that LBH and SHF are associated with the Alzheimer's disease pathogenesis.
    Title: Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer's disease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
SH2 domain-containing adapter protein F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013829.2 → NP_001013851.2  SH2 domain-containing adapter protein F isoform 2

    See identical proteins and their annotated locations for NP_001013851.2

    Status: VALIDATED

    Source sequence(s)
    AI413498, AL844566, CB056323, CX222912
    Consensus CDS
    CCDS16662.1
    UniProtKB/Swiss-Prot
    A2AQ90, A2AQ91, Q8CG80
    Related
    ENSMUSP00000106160.3, ENSMUST00000110531.9
    Conserved Domains (1) summary
    cd10392
    Location:136 → 233
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)

  2. NM_001374011.1 → NP_001360940.1  SH2 domain-containing adapter protein F isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL844566
    UniProtKB/TrEMBL
    A2AQ87
    Related
    ENSMUSP00000117099.2, ENSMUST00000125826.8
    Conserved Domains (1) summary
    cd10392
    Location:381 → 478
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    122179373..122199650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162368.1 → XP_036018261.1  SH2 domain-containing adapter protein F isoform X1

    UniProtKB/TrEMBL
    A2AQ87
    Conserved Domains (1) summary
    cd10392
    Location:305 → 400
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)

  2. XM_017319108.3 → XP_017174597.1  SH2 domain-containing adapter protein F isoform X2

    UniProtKB/TrEMBL
    A2AQ89
    Related
    ENSMUSP00000119980.2, ENSMUST00000139819.8
    Conserved Domains (2) summary
    cd10392
    Location:183 → 280
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)
    PHA03247
    Location:8 → 179
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CG80.2 GenPept UniProtKB/Swiss-Prot:Q8CG80

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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