Shisa8 shisa family member 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Shisa8provided by MGI
Official Full Name: shisa family member 8provided by MGI
Primary source: MGI:MGI:2146080
See related: Ensembl:ENSMUSG00000096883 AllianceGenome:MGI:2146080
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Orf26; ckamp39
Summary: Predicted to be involved in regulation of AMPA receptor activity and regulation of short-term neuronal synaptic plasticity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in dendritic spine membrane; postsynaptic density; and postsynaptic membrane. Is expressed in cerebellum and main olfactory bulb. Orthologous to human SHISA8 (shisa family member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in ovary adult (RPKM 20.8), cerebellum adult (RPKM 20.1) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15; 15 E1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (82091153..82097004, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (82206173..82212848, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study indicates that AMPAR function is very precisely controlled by the cell-type specific expression of the CKAMP family members 39, 52 and 59.
Title: Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in regulation of AMPA receptor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of short-term neuronal synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendritic spine membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein shisa-8

Names: cysteine-knot AMPAR-modulating protein 39; cystine-knot AMPAR modulating protein of 39 kDa; putative protein shisa-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001207021.2 → NP_001193950.1 protein shisa-8 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC105358

Consensus CDS

CCDS56994.1

UniProtKB/Swiss-Prot

J3QNX5

Related

ENSMUSP00000137002.2, ENSMUST00000179269.3

Conserved Domains (1) summary

pfam13908
Location:55 → 176

Shisa; Wnt and FGF inhibitory regulator
NM_001415947.1 → NP_001402876.1 protein shisa-8 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC105358
NM_001415948.1 → NP_001402877.1 protein shisa-8 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC105358
NM_001415949.1 → NP_001402878.1 protein shisa-8 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC105358