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Zfp141 zinc finger protein 141 [ Mus musculus (house mouse) ]

Gene ID: 434178, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp141provided by MGI
Official Full Name
zinc finger protein 141provided by MGI
Primary source
MGI:MGI:3584269
See related
Ensembl:ENSMUSG00000092416 AllianceGenome:MGI:3584269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 3.1), CNS E11.5 (RPKM 2.9) and 25 other tissues See more
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Genomic context

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Location:
7 B3; 7 28.25 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (42122810..42155171, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (42473386..42505778, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor, pseudogene 60 Neighboring gene RIKEN cDNA 4933421I07 gene Neighboring gene STARR-seq mESC enhancer starr_18739 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4921 Neighboring gene predicted gene, 35353 Neighboring gene STARR-seq mESC enhancer starr_18740 Neighboring gene STARR-seq mESC enhancer starr_18741 Neighboring gene predicted gene, 53386 Neighboring gene STARR-seq mESC enhancer starr_18742

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 141

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309388.2 → NP_001296317.1  zinc finger protein 141 isoform 1

    See identical proteins and their annotated locations for NP_001296317.1

    Status: VALIDATED

    Source sequence(s)
    AC102606
    Consensus CDS
    CCDS85276.1
    UniProtKB/TrEMBL
    G3UY09
    Related
    ENSMUSP00000133899.2, ENSMUST00000174407.3
    Conserved Domains (4) summary
    smart00349
    Location:18 → 78
    KRAB; krueppel associated box
    COG5048
    Location:445 → 685
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:580 → 600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:424 → 449
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001309389.2 → NP_001296318.1  zinc finger protein 141 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102606
    Conserved Domains (4) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:399 → 639
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:534 → 554
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:602 → 626
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001421545.1 → NP_001408474.1  zinc finger protein 141 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC102606
    UniProtKB/TrEMBL
    G3UY09

  4. NM_001421546.1 → NP_001408475.1  zinc finger protein 141 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC102606
    UniProtKB/TrEMBL
    G3UY09

  5. NM_001421548.1 → NP_001408477.1  zinc finger protein 141 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC102606

  6. NM_001421550.1 → NP_001408479.1  zinc finger protein 141 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC102606

  7. NM_001421553.1 → NP_001408482.1  zinc finger protein 141 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC102606

  8. NM_001421555.1 → NP_001408484.1  zinc finger protein 141 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC102606

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    42122810..42155171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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