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Zfp268 zinc finger protein 268 [ Mus musculus (house mouse) ]

Gene ID: 433801, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp268provided by MGI
Official Full Name
zinc finger protein 268provided by MGI
Primary source
MGI:MGI:3651014
See related
Ensembl:ENSMUSG00000078502 AllianceGenome:MGI:3651014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm13212
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in actin cytoskeleton and cytosol. Predicted to be active in nucleus. Orthologous to several human genes including ZNF808 (zinc finger protein 808) and ZNF845 (zinc finger protein 845). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Zfp268 in Genome Data Viewer
Location:
4 E1; 4 78.22 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (145311770..145351915)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (145585172..145625343)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene high mobility group protein B1-like Neighboring gene predicted gene 13226 Neighboring gene STARR-seq mESC enhancer starr_12032 Neighboring gene STARR-seq mESC enhancer starr_12033 Neighboring gene STARR-positive B cell enhancer mm9_chr4:145209707-145210007 Neighboring gene predicted gene 13234 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC433801
Names
novel KRAB box containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324416.1 → NP_001311345.1  uncharacterized protein LOC433801

    Status: VALIDATED

    Source sequence(s)
    AL627304, AL713973
    Consensus CDS
    CCDS84823.1
    UniProtKB/TrEMBL
    B1ASQ7
    Related
    ENSMUSP00000101365.2, ENSMUST00000105739.8
    Conserved Domains (3) summary
    COG5048
    Location:320 → 717
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:464 → 484
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 52
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    145311770..145351915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164220.1 → XP_036020113.1  uncharacterized protein LOC433801 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:269 → 418
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:273 → 293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 52
    KRAB; KRAB box
    pfam13465
    Location:229 → 254
    zf-H2C2_2; Zinc-finger double domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013808.2: Suppressed sequence

    Description
    NM_001013808.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_001205101.1: Suppressed sequence

    Description
    NM_001205101.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version

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