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Micos10 mitochondrial contact site and cristae organizing system subunit 10 [ Mus musculus (house mouse) ]

Gene ID: 433771, updated on 5-Mar-2024

Summary

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Official Symbol
Micos10provided by MGI
Official Full Name
mitochondrial contact site and cristae organizing system subunit 10provided by MGI
Primary source
MGI:MGI:1913628
See related
Ensembl:ENSMUSG00000050608 AllianceGenome:MGI:1913628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Minos1; 2310028O11Rik
Summary
Located in mitochondrion. Orthologous to human MICOS10 (mitochondrial contact site and cristae organizing system subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 24.4), heart adult (RPKM 23.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D3; 4 70.57 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138829125..138858667, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (139101814..139131113, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 6 Neighboring gene STARR-positive B cell enhancer ABC_E4693 Neighboring gene NBL1, DAN family BMP antagonist Neighboring gene STARR-positive B cell enhancer ABC_E9606 Neighboring gene predicted gene, 33304 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 4 Neighboring gene STARR-positive B cell enhancer mm9_chr4:138725170-138725470 Neighboring gene predicted gene 16287

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of MICOS complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
MICOS complex subunit Mic10
Names
UPF0327 protein C1orf151 homolog
mitochondrial inner membrane organizing system 1
mitochondrial inner membrane organizing system protein 1
novel DUF543 domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163006.2 → NP_001156478.1  MICOS complex subunit Mic10

    See identical proteins and their annotated locations for NP_001156478.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the conserved protein.
    Source sequence(s)
    AK030343, AL807811, BF465511
    Consensus CDS
    CCDS51339.1
    UniProtKB/Swiss-Prot
    A2ALL2, Q3U6N5, Q7TNS2
    Related
    ENSMUSP00000117583.2, ENSMUST00000143971.2
    Conserved Domains (1) summary
    pfam04418
    Location:1 → 62
    DUF543; Domain of unknown function (DUF543)

RNA

  1. NR_033745.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA023452, AK030343, AL807811, AW226897, BF465511

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    138829125..138858667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004941931.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNS2.1 GenPept UniProtKB/Swiss-Prot:Q7TNS2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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