U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Maml3 mastermind like transcriptional coactivator 3 [ Mus musculus (house mouse) ]

Gene ID: 433586, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Maml3provided by MGI
Official Full Name
mastermind like transcriptional coactivator 3provided by MGI
Primary source
MGI:MGI:2389461
See related
Ensembl:ENSMUSG00000061143 AllianceGenome:MGI:2389461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mam-2; mKIAA1816
Summary
Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription of Notch receptor target. Predicted to be located in nuclear speck. Predicted to be active in nucleoplasm. Is expressed in several structures, including forelimb bud; genitourinary system; neural ectoderm; pancreas epithelium; and paraxial mesenchyme. Orthologous to human MAML3 (mastermind like transcriptional coactivator 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 5.1), colon adult (RPKM 3.4) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Maml3 in Genome Data Viewer
Location:
3 C; 3 22.54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (51595032..52012740, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (51687320..52105319, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5031434O11 gene Neighboring gene SET domain containing (lysine methyltransferase) 7 Neighboring gene STARR-seq mESC enhancer starr_07617 Neighboring gene STARR-seq mESC enhancer starr_07618 Neighboring gene STARR-seq mESC enhancer starr_07619 Neighboring gene STARR-seq mESC enhancer starr_07620 Neighboring gene STARR-positive B cell enhancer ABC_E11183 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51440808-51440917 Neighboring gene STARR-seq mESC enhancer starr_07621 Neighboring gene STARR-seq mESC enhancer starr_07622 Neighboring gene STARR-seq mESC enhancer starr_07623 Neighboring gene STARR-seq mESC enhancer starr_07624 Neighboring gene predicted gene, 38247 Neighboring gene microsomal glutathione S-transferase 2 Neighboring gene VISTA enhancer mm1010 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51549117-51549270 Neighboring gene predicted gene, 46803 Neighboring gene VISTA enhancer mm1452 Neighboring gene STARR-seq mESC enhancer starr_07625 Neighboring gene VISTA enhancer mm1388 Neighboring gene STARR-seq mESC enhancer starr_07626 Neighboring gene STARR-positive B cell enhancer ABC_E1019 Neighboring gene STARR-positive B cell enhancer ABC_E7911 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51839623-51839732 Neighboring gene STARR-positive B cell enhancer ABC_E3430 Neighboring gene predicted gene, 30074 Neighboring gene STARR-seq mESC enhancer starr_07632 Neighboring gene olfactory receptor family 14 subfamily M member 1, pseudogene 1 Neighboring gene predicted gene, 30125

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of oscillatory genes in somitogenesis from functional genomic analysis of a human mesenchymal stem cell model. William DA, et al. Dev Biol, 2007 May 1. PMID 17362910, Free PMC Article
  2. Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Wu L, et al. Mol Cell Biol, 2002 Nov. PMID 12370315, Free PMC Article
  3. Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo. Oyama T, et al. Development, 2011 Dec. PMID 22069191
  4. The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. Chalamalasetty RB, et al. Nat Commun, 2011 Jul 12. PMID 21750544, Free PMC Article
  5. The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organs. Moayedi Y, et al. PLoS Genet, 2014 Jan. PMID 24391519, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.
    Title: Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA1816, MGC59565

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription of Notch receptor target IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
mastermind-like protein 3
Names
mastermind like 3
mastermind-2
mastermind-like 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004176.3 → NP_001004176.2  mastermind-like protein 3

    See identical proteins and their annotated locations for NP_001004176.2

    Status: VALIDATED

    Source sequence(s)
    AC116729, AC158347
    Consensus CDS
    CCDS17342.2
    UniProtKB/TrEMBL
    D4QGC2
    Related
    ENSMUSP00000112637.2, ENSMUST00000121440.4
    Conserved Domains (1) summary
    pfam09596
    Location:67 → 124
    MamL-1; MamL-1 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    51595032..52012740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501645.5 → XP_006501708.1  mastermind-like protein 3 isoform X1

    Conserved Domains (3) summary
    PRK13042
    Location:336 → 427
    PRK13042; superantigen-like protein SSL4; Reviewed
    pfam09606
    Location:778 → 1038
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam09596
    Location:67 → 124
    MamL-1; MamL-1 domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous