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Zscan26 zinc finger and SCAN domain containing 26 [ Mus musculus (house mouse) ]

Gene ID: 432731, updated on 5-Mar-2024

Summary

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Official Symbol
Zscan26provided by MGI
Official Full Name
zinc finger and SCAN domain containing 26provided by MGI
Primary source
MGI:MGI:3531417
See related
Ensembl:ENSMUSG00000022228 AllianceGenome:MGI:3531417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp187; Znf187
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including gut; metatarsal bone; rest of cerebellum ventricular layer; sensory organ; and telencephalon. Orthologous to human ZSCAN26 (zinc finger and SCAN domain containing 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 25.1), cerebellum adult (RPKM 17.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A3.1; 13 7.8 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (21626344..21637901, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21442180..21453727, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger with KRAB and SCAN domains 3 Neighboring gene STARR-seq mESC enhancer starr_33849 Neighboring gene STARR-positive B cell enhancer ABC_E10783 Neighboring gene microRNA 6942 Neighboring gene piggyBac transposable element derived 1 Neighboring gene RIKEN cDNA 4930470G03 gene Neighboring gene microRNA 1896 Neighboring gene STARR-positive B cell enhancer ABC_E11532 Neighboring gene NFKB activating protein-like Neighboring gene zinc finger with KRAB and SCAN domains 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comprehensive interactome of Otx2 in the adult mouse neural retina. Fant B, et al. Genesis, 2015 Nov. PMID 26426291
  2. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and SCAN domain-containing protein 26
Names
zinc finger protein 187

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013786.4 → NP_001013808.2  zinc finger and SCAN domain-containing protein 26 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    BX001068
    Consensus CDS
    CCDS49211.1
    UniProtKB/TrEMBL
    F8WJ31
    Related
    ENSMUSP00000032820.7, ENSMUST00000032820.15
    Conserved Domains (3) summary
    COG5048
    Location:136 → 297
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:146 → 166
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:158 → 183
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001347491.2 → NP_001334420.1  zinc finger and SCAN domain-containing protein 26 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BX001068
    Consensus CDS
    CCDS84009.1
    UniProtKB/Swiss-Prot
    Q5RJ54, Q6NVD7
    Related
    ENSMUSP00000106111.2, ENSMUST00000110485.3
    Conserved Domains (3) summary
    COG5048
    Location:253 → 463
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:272 → 292
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:43 → 151
    SCAN; SCAN oligomerization domain

  3. NM_001426343.1 → NP_001413272.1  zinc finger and SCAN domain-containing protein 26 isoform a

    Status: VALIDATED

    Source sequence(s)
    BX001068
    UniProtKB/Swiss-Prot
    Q5RJ54, Q6NVD7

  4. NM_001426344.1 → NP_001413273.1  zinc finger and SCAN domain-containing protein 26 isoform 3

    Status: VALIDATED

    Source sequence(s)
    BX001068

  5. NM_001426345.1 → NP_001413274.1  zinc finger and SCAN domain-containing protein 26 isoform 4

    Status: VALIDATED

    Source sequence(s)
    BX001068

  6. NM_001426346.1 → NP_001413275.1  zinc finger and SCAN domain-containing protein 26 isoform 5

    Status: VALIDATED

    Source sequence(s)
    BX001068

  7. NM_001426347.1 → NP_001413276.1  zinc finger and SCAN domain-containing protein 26 isoform 6

    Status: VALIDATED

    Source sequence(s)
    BX001068

  8. NM_001426348.1 → NP_001413277.1  zinc finger and SCAN domain-containing protein 26 isoform 7

    Status: VALIDATED

    Source sequence(s)
    BX001068

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    21626344..21637901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RJ54.1 GenPept UniProtKB/Swiss-Prot:Q5RJ54

Gene LinkOut

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