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Tmprss9 transmembrane protease, serine 9 [ Mus musculus (house mouse) ]

Gene ID: 432478, updated on 5-Mar-2024

Summary

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Official Symbol
Tmprss9provided by MGI
Official Full Name
transmembrane protease, serine 9provided by MGI
Primary source
MGI:MGI:3612246
See related
Ensembl:ENSMUSG00000059406 AllianceGenome:MGI:3612246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Serase-1B
Summary
Enables serine-type peptidase activity. Acts upstream of or within plasminogen activation. Used to study autism spectrum disorder. Orthologous to human TMPRSS9 (transmembrane serine protease 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 19.4), testis adult (RPKM 1.4) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80706951..80735329)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80871117..80899495)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6885 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene signal peptide peptidase like 2B Neighboring gene translocase of inner mitochondrial membrane 13 Neighboring gene lamin B2 Neighboring gene STARR-positive B cell enhancer ABC_E721 Neighboring gene growth arrest and DNA-damage-inducible 45 beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and analysis of the promoter region of the type II transmembrane serine protease polyserase-1 and its transcript variants. Hayama M, et al. Biol Chem, 2007 Aug. PMID 17655505
  2. Combination of whole exome sequencing and animal modeling identifies TMPRSS9 as a candidate gene for autism spectrum disorder. Chen CA, et al. Hum Mol Genet, 2020 Feb 1. PMID 31943016, Free PMC Article
  3. Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminoglycans. Okumura Y, et al. Biochem J, 2006 Dec 15. PMID 16872279, Free PMC Article
  4. Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. Cal S, et al. Proc Natl Acad Sci U S A, 2003 Aug 5. PMID 12886014, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Combination of whole exome sequencing and animal modeling identifies TMPRSS9 as a candidate gene for autism spectrum disorder.
    Title: Combination of whole exome sequencing and animal modeling identifies TMPRSS9 as a candidate gene for autism spectrum disorder.
  2. These data suggest that the expression of mpolyserase-1 and its transcript variants is positively regulated by the E-box in its 5'-UTR.
    Title: Identification and analysis of the promoter region of the type II transmembrane serine protease polyserase-1 and its transcript variants.
  3. The isolation and characterization of serase-1B, a splice variant of polyserase-1, is reported.
    Title: Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminoglycans.
  4. Figure 6 in the publisher's supporting information shows an alignment of the identified (human) and predicted (mouse and rat) amino acid sequences.
    Title: Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type peptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within plasminogen activation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protease serine 9
Names
polyserase-1
polyserase-I
polyserine protease-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081688.2 → NP_001075157.2  transmembrane protease serine 9

    Status: VALIDATED

    Source sequence(s)
    AC152413, AC166937
    Consensus CDS
    CCDS48641.1
    UniProtKB/TrEMBL
    B2RY54, D3YTR8
    Related
    ENSMUSP00000100970.3, ENSMUST00000105333.3
    Conserved Domains (4) summary
    smart00020
    Location:238 → 467
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:190 → 225
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:239 → 467
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:68 → 148
    SEA; SEA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80706951..80735329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513843.2 → XP_006513906.2  transmembrane protease serine 9 isoform X2

    UniProtKB/TrEMBL
    B2RY54
    Conserved Domains (4) summary
    smart00020
    Location:748 → 976
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:407 → 442
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:1077 → 1328
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:285 → 365
    SEA; SEA domain

  2. XM_006513842.2 → XP_006513905.2  transmembrane protease serine 9 isoform X1

    UniProtKB/TrEMBL
    B2RY54
    Conserved Domains (4) summary
    smart00020
    Location:455 → 684
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:407 → 442
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:1085 → 1336
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:285 → 365
    SEA; SEA domain

  3. XM_006513845.2 → XP_006513908.2  transmembrane protease serine 9 isoform X4

    UniProtKB/TrEMBL
    B2RY54
    Conserved Domains (4) summary
    smart00020
    Location:455 → 684
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:407 → 442
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:1085 → 1310
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:285 → 365
    SEA; SEA domain

  4. XM_006513844.2 → XP_006513907.2  transmembrane protease serine 9 isoform X3

    UniProtKB/TrEMBL
    B2RY54
    Conserved Domains (3) summary
    smart00020
    Location:441 → 670
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:393 → 428
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01390
    Location:285 → 365
    SEA; SEA domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P69525.1 GenPept UniProtKB/Swiss-Prot:P69525

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