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MGST3 microsomal glutathione S-transferase 3 [ Homo sapiens (human) ]

Gene ID: 4259, updated on 7-Apr-2024

Summary

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Official Symbol
MGST3provided by HGNC
Official Full Name
microsomal glutathione S-transferase 3provided by HGNC
Primary source
HGNC:HGNC:7064
See related
Ensembl:ENSG00000143198 MIM:604564; AllianceGenome:HGNC:7064
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GST-3; GST-III
Summary
This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]
Expression
Ubiquitous expression in heart (RPKM 114.7), fat (RPKM 75.6) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
1q24.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (165631234..165656136)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (164977647..165002573)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (165600471..165625373)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene LRRC52 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:165565420-165565627 Neighboring gene ribosomal protein S2 pseudogene 10 Neighboring gene tRNA-Lys (anticodon CTT) 13-1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:165571612-165571772 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:165599392-165599922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2018 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:165619651-165620850 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:165626303-165626469 Neighboring gene aldehyde dehydrogenase 9 family member A1 Neighboring gene ribosomal protein S13 pseudogene 1 Neighboring gene ribosomal protein L21 pseudogene 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Biosynthesis of prostaglandin 15dPGJ(2) -glutathione and 15dPGJ(2)-cysteine conjugates in macrophages and mast cells via MGST3. Steinmetz-Späh J, et al. J Lipid Res, 2022 Dec. PMID 36370807, Free PMC Article
  2. Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease. Ashbrook DG, et al. BMC Genomics, 2014 Oct 3. PMID 25280473, Free PMC Article
  3. Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians. Thameem F, et al. Hum Genet, 2003 Sep. PMID 12898215
  4. Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily. Jakobsson PJ, et al. Am J Respir Crit Care Med, 2000 Feb. PMID 10673221
  5. Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. Jakobsson PJ, et al. J Biol Chem, 1997 Sep 5. PMID 9278457

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Variants in MGST3 are associated with differences inn hippocampus size in both human brain data sets (ENIGMA MRI) and in the BXD family of mice. MGST3 is also statistically associated to genes linked to neurodegenerative disorders, including Parkinson's, Huntington's, and Alzheimer's diseases.
    Title: Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of microsomal glutathione S-transferase 3 (MGST3) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables leukotriene-C4 synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in leukotriene biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in prostanoid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glutathione S-transferase 3, mitochondrial
Names
LTC4 synthase MGST3
glutathione peroxidase MGST3
microsomal GST-3
microsomal GST-III
microsomal glutathione S-transferase III
NP_004519.1
XP_047276986.1
XP_054192641.1
XP_054192642.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004528.4 → NP_004519.1  glutathione S-transferase 3, mitochondrial

    See identical proteins and their annotated locations for NP_004519.1

    Status: REVIEWED

    Source sequence(s)
    AI591182, AL356441, AL451074, BC000505
    Consensus CDS
    CCDS1249.1
    UniProtKB/Swiss-Prot
    B2R592, O14880, Q6ICN4
    UniProtKB/TrEMBL
    Q53GB9
    Related
    ENSP00000356864.3, ENST00000367889.8
    Conserved Domains (1) summary
    pfam01124
    Location:11 → 130
    MAPEG; MAPEG family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    165631234..165656136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421030.1 → XP_047276986.1  glutathione S-transferase 3, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q5VV89
    Related
    ENSP00000356860.1, ENST00000367885.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    164977647..165002573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336666.1 → XP_054192641.1  glutathione S-transferase 3, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q5VV89

  2. XM_054336667.1 → XP_054192642.1  glutathione S-transferase 3, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q5VV89
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14880.1 GenPept UniProtKB/Swiss-Prot:O14880

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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