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MtnB Metallothionein B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42424, updated on 4-Apr-2024

Summary

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Official Symbol
MtnBprovided by FlyBase
Official Full Name
Metallothionein Bprovided by FlyBase
Primary source
FLYBASE:FBgn0002869
Locus tag
Dmel_CG4312
See related
AllianceGenome:FB:FBgn0002869
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4312; Dmel\CG4312; DrosMto; MT; MTN; MtnA; mtnb; mtnB; MTNB; Mto; MTO
Summary
Enables copper ion binding activity. Involved in metal ion homeostasis and response to metal ion. Is expressed in embryonic/larval posterior midgut and gastric caecum. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
92E12-92E13; 3-68 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20503102..20503746, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16328824..16329468, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44401 Neighboring gene Dicarboxylate carrier 2 Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 92a Neighboring gene Major Facilitator Superfamily Transporter 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Metal-metal interaction mediates the iron induction of Drosophila MtnB. Qiang W, et al. Biochem Biophys Res Commun, 2017 Jun 3. PMID 28435068
  2. The ovicidal, larvacidal and adulticidal properties of 5,5'-dimethyl-2,2'-bipyridyl against Drosophila melanogaster. Van Hiel MB, et al. PLoS One, 2012. PMID 23185497, Free PMC Article
  3. Raman study of in vivo synthesized Zn(II)-metallothionein complexes: structural insight into metal clusters and protein folding. Torreggiani A, et al. Biopolymers, 2008 Dec. PMID 18690663
  4. Drosophila ZnT1 is essential in the intestine for dietary zinc absorption. Wang Z, et al. Biochem Biophys Res Commun, 2020 Dec 17. PMID 33012507
  5. Chronic lead (Pb) exposure results in diminished hemocyte count and increased susceptibility to bacterial infection in Drosophila melanogaster. Nanda KP, et al. Chemosphere, 2019 Dec. PMID 31326753

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thus, iron-mediated MtnB induction appears resulting from interrupted homeostasis of other metals such as zinc, which in turns induced MtnB expression. Metal-metal interaction may more widely exist than we expected.
    Title: Metal-metal interaction mediates the iron induction of Drosophila MtnB.
  2. MTO metal binding features were analyzed for comparison with MTN, the paralogous Drosophila metallothionein, and to classify MTO as either zinc- or copper-thionein.
    Title: MTO: the second member of a Drosophila dual copper-thionein system.
  3. the preferential protection against copper and cadmium toxicity by MtnA and MtnB, respectively, are the result of a combination of promoter preference and metal binding
    Title: The four members of the Drosophila metallothionein family exhibit distinct yet overlapping roles in heavy metal homeostasis and detoxification.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables copper ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular detoxification of metal ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to metal ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to metal ion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
metallothionein B
Names
CG4312-PA
CG4312-PB
CG4312-PC
MtnB-PA
MtnB-PB
MtnB-PC
metallothionein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20503102..20503746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300497.1 → NP_001287426.1  metallothionein B, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287426.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P11956, Q1ECC1, Q9VDM2
    UniProtKB/TrEMBL
    A0A0B4LHD1
    Conserved Domains (1) summary
    pfam02067
    Location:1 → 41
    Metallothio_5; Metallothionein family 5

  2. NM_001300496.1 → NP_001287425.1  metallothionein B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287425.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P11956, Q1ECC1, Q9VDM2
    UniProtKB/TrEMBL
    A0A0B4LHD1
    Conserved Domains (1) summary
    pfam02067
    Location:1 → 41
    Metallothio_5; Metallothionein family 5

  3. NM_079689.3 → NP_524413.1  metallothionein B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524413.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P11956, Q1ECC1, Q9VDM2
    UniProtKB/TrEMBL
    A0A0B4LHD1
    Related
    FBpp0083298
    Conserved Domains (1) summary
    pfam02067
    Location:1 → 41
    Metallothio_5; Metallothionein family 5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LHD1 A0A0B4LHD1
P11956.1 P11956

Gene LinkOut

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