cher cheerio [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cherprovided by FlyBase
Official Full Name: cheerioprovided by FlyBase
Primary source: FLYBASE:FBgn0014141
Locus tag: Dmel_CG3937
See related: AllianceGenome:FB:FBgn0014141
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3937; Cheerio; Cher; dFil; Dmel\CG3937; Fil; filamin; FLN; FLN90; joy; sko
Summary: Predicted to enable actin binding activity. Involved in several processes, including actin cytoskeleton organization; behavioral response to ethanol; and oogenesis. Located in several cellular components, including Z disc; actin cytoskeleton; and female germline ring canal. Colocalizes with actin filament; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including adult heart; embryonic/larval midgut; gastrula embryo; gonad; and presumptive embryonic/larval digestive system. Used to study myopathy. Human ortholog(s) of this gene implicated in several diseases, including Larsen syndrome; X-linked recessive disease (multiple); bone development disease (multiple); heart valve disease (multiple); and myopathy (multiple). Orthologous to several human genes including FLNB (filamin B) and FLNC (filamin C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 89E12-89F1; 3-59 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (17091533..17125389, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (12917255..12951111, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila CRISPR/Cas9 mutants as tools to analyse cardiac filamin function and pathogenicity of human FLNC variants.
Title: Drosophila CRISPR/Cas9 mutants as tools to analyse cardiac filamin function and pathogenicity of human FLNC variants.
The PDZ domain binding motif found in the most C-terminal region of the Sema-1a ICD is necessary for interaction with Vari, but not Cher, indicative of distinct binding modalities. Pbl/Sema-1a-mediated repulsive guidance is potentiated by both vari and cher Genetic analyses further suggest that scaffolding functions of Vari and Cher play an important role in Pbl-mediated Sema-1a reverse signaling.
Title: Varicose and cheerio collaborate with pebble to mediate semaphorin-1a reverse signaling in Drosophila.
FLN90, an isoform of the Drosophila ortholog Filamin/cheerio that lacks the actin-binding domain, is here shown to govern the growth of postsynaptic membrane folds and the composition of glutamate receptor clusters at the larval neuromuscular junction.
Title: Filamin, a synaptic organizer in Drosophila, determines glutamate receptor composition and membrane growth.
Here we show using Drosophila indirect flight muscle that the filamin ortholog Cheerio in conjunction with the giant elastic protein titin plays a crucial role in keeping thin filaments stably anchored at the Z-disc. We identify the filamin domains required for interaction with the titin ortholog Sallimus, and we demonstrate a genetic interaction of filamin with titin and actin.
Title: Filamin actin-binding and titin-binding fulfill distinct functions in Z-disc cohesion.
study identifies Cher as a new target of JNK signaling that links cytoskeleton dynamics to tumor progression.
Title: The actin cross-linker Filamin/Cheerio mediates tumor malignancy downstream of JNK signaling.
Data indicate that during embryonic development, the expression of Filamin and Ten-m partially overlap in ectodermal cells.
Title: Drosophila Ten-m and filamin affect motor neuron growth cone guidance.
Filamin is required for ovarian follicle cell motility during oogenesis.
Title: Drosophila filamin is required for follicle cell motility during oogenesis.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c17120964-17120915 mobile_element_type = transposon:INE-1{}5741

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables actin filament binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germline ring canal formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germline ring canal formation, actin assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived female germ-line cyst encapsulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germline ring canal formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	HMP more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lamellocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in syncytial embryo cellularization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in apical cortex	HDA more info	PubMed
colocalizes_with contractile ring	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in female germline ring canal	IDA Inferred from Direct Assay more info	PubMed
located_in female germline ring canal inner rim	IDA Inferred from Direct Assay more info	PubMed
located_in female germline ring canal outer rim	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with nucleus	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cheerio

Names: CG3937-PA; CG3937-PB; CG3937-PF; CG3937-PG; CG3937-PH; CG3937-PI; CG3937-PK; CG3937-PM; CG3937-PO; CG3937-PP; Filamin-1; Filamin-A; Filamin-B; cher-PA; cher-PB; cher-PF; cher-PG; cher-PH; cher-PI; cher-PK; cher-PM; cher-PO; cher-PP; cherrio; filamin; filamin B; filamin isoform B; filamin-240; shi kong

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

17091533..17125389 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275728.1 → NP_001262657.2 cheerio, isoform P [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KG47, Q9GQV2

Conserved Domains (4) summary

smart00557
Location:1104 → 1191

IG_FLMN; Filamin-type immunoglobulin domains

pfam00630
Location:1192 → 1288

Filamin; Filamin/ABP280 repeat

cd21311
Location:175 → 297

CH_dFLNA-like_rpt1; first calponin homology (CH) domain found in Drosophila melanogaster filamin-A (dFLNA) and similar proteins

cd21315
Location:298 → 415

CH_dFLNA-like_rpt2; second calponin homology (CH) domain found in Drosophila melanogaster filamin-A (dFLNA) and similar proteins
NM_001275730.1 → NP_001262659.2 cheerio, isoform O [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHN1, Q9GQV2

Conserved Domains (4) summary

smart00557
Location:1109 → 1196

IG_FLMN; Filamin-type immunoglobulin domains

pfam00630
Location:1197 → 1293

Filamin; Filamin/ABP280 repeat

cd21311
Location:175 → 297

CH_dFLNA-like_rpt1; first calponin homology (CH) domain found in Drosophila melanogaster filamin-A (dFLNA) and similar proteins

cd21315
Location:298 → 415

CH_dFLNA-like_rpt2; second calponin homology (CH) domain found in Drosophila melanogaster filamin-A (dFLNA) and similar proteins
NM_001202309.1 → NP_001189238.1 cheerio, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189238.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JCY6, Q9GQV2

Conserved Domains (4) summary

smart00033
Location:175 → 267

CH; Calponin homology domain

smart00557
Location:965 → 1055

IG_FLMN; Filamin-type immunoglobulin domains

cd00014
Location:46 → 149

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam00630
Location:963 → 1049

Filamin; Filamin/ABP280 repeat
NM_001275729.1 → NP_001262658.1 cheerio, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262658.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGT8, Q9GQV2

Conserved Domains (4) summary

smart00033
Location:175 → 267

CH; Calponin homology domain

smart00557
Location:961 → 1048

IG_FLMN; Filamin-type immunoglobulin domains

cd00014
Location:46 → 149

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam00630
Location:957 → 1042

Filamin; Filamin/ABP280 repeat
NM_079659.4 → NP_524383.3 cheerio, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524383.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KJX2, Q7KKC2, Q9GQV1, Q9U4I3, Q9U6C0, Q9U6C1, Q9VEN1

UniProtKB/TrEMBL

Q9GQV2

Conserved Domains (4) summary

smart00033
Location:145 → 237

CH; Calponin homology domain

smart00557
Location:935 → 1025

IG_FLMN; Filamin-type immunoglobulin domains

cd00014
Location:16 → 119

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam00630
Location:933 → 1019

Filamin; Filamin/ABP280 repeat
NM_206502.3 → NP_996224.2 cheerio, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996224.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7KSF4, Q9GQV2

Conserved Domains (4) summary

smart00033
Location:145 → 237

CH; Calponin homology domain

smart00557
Location:931 → 1018

IG_FLMN; Filamin-type immunoglobulin domains

cd00014
Location:16 → 119

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam00630
Location:927 → 1012

Filamin; Filamin/ABP280 repeat
NM_001275727.1 → NP_001262656.1 cheerio, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262656.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGB3, Q6NN54

Conserved Domains (2) summary

smart00557
Location:433 → 521

IG_FLMN; Filamin-type immunoglobulin domains

pfam00630
Location:372 → 420

Filamin; Filamin/ABP280 repeat
NM_169747.2 → NP_732208.2 cheerio, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732208.2

Status: REVIEWED

UniProtKB/TrEMBL

A4V310, C7LAD0

Conserved Domains (2) summary

smart00557
Location:452 → 540

IG_FLMN; Filamin-type immunoglobulin domains

pfam00630
Location:391 → 439

Filamin; Filamin/ABP280 repeat
NM_001144595.2 → NP_001138067.1 cheerio, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138067.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z0L2, C7LAD1

Conserved Domains (2) summary

smart00557
Location:514 → 602

IG_FLMN; Filamin-type immunoglobulin domains

pfam00630
Location:453 → 501

Filamin; Filamin/ABP280 repeat
NM_169746.3 → NP_732207.1 cheerio, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732207.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGB3, Q6NN54

Related

FBpp0088480

Conserved Domains (2) summary

smart00557
Location:433 → 521

IG_FLMN; Filamin-type immunoglobulin domains

pfam00630
Location:372 → 420

Filamin; Filamin/ABP280 repeat

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4JCY6		A0A0B4JCY6
A0A0B4KG47		A0A0B4KG47
A0A0B4KGB3		A0A0B4KGB3
A0A0B4KGT8		A0A0B4KGT8
A0A0B4KHN1		A0A0B4KHN1
A4V310		A4V310
B7Z0L2		B7Z0L2
Q7KSF4		Q7KSF4
Q8T3K7		Q8T3K7
Q9GQV2		Q9GQV2
Q9VEN1.2		Q9VEN1