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Der-2 Derlin-2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42005, updated on 11-Apr-2024

Summary

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Official Symbol
Der-2provided by FlyBase
Official Full Name
Derlin-2provided by FlyBase
Primary source
FLYBASE:FBgn0038438
Locus tag
Dmel_CG14899
See related
AllianceGenome:FB:FBgn0038438
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cg14899; CG14899; dDer-2; DER1; Dmel\CG14899
Summary
Predicted to enable misfolded protein binding activity and ubiquitin-specific protease binding activity. Involved in defense response to bacterium. Predicted to be part of Hrd1p ubiquitin ligase ERAD-L complex. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in adult head and organism. Orthologous to several human genes including DERL2 (derlin 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Der-2 in Genome Data Viewer
Location:
89B18-89B18; 3-58 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16482694..16484223, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12308416..12309945, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46029 Neighboring gene Guanylyl cyclase at 89Db Neighboring gene Succinate dehydrogenase assembly factor 3 Neighboring gene Dihydrofolate reductase Neighboring gene Cadherin 89D Neighboring gene Gustatory receptor 89a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation. Kang MJ, et al. Proc Natl Acad Sci U S A, 2009 Oct 6. PMID 19805114, Free PMC Article
  2. Derlin-1 regulates mutant VCP-linked pathogenesis and endoplasmic reticulum stress-induced apoptosis. Liang CJ, et al. PLoS Genet, 2014 Sep. PMID 25255315, Free PMC Article
  3. Wolbachia endosymbionts subvert the endoplasmic reticulum to acquire host membranes without triggering ER stress. Fattouh N, et al. PLoS Negl Trop Dis, 2019 Mar. PMID 30893296, Free PMC Article
  4. Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection. Ayres JS, et al. Genetics, 2008 Mar. PMID 18245331, Free PMC Article
  5. Fast sequence evolution of Hox and Hox-derived genes in the genus Drosophila. Casillas S, et al. BMC Evol Biol, 2006 Dec 12. PMID 17163987, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables signal recognition particle binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum unfolded protein response ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Derlin-2
Names
CG14899-PA
Der-2-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16482694..16484223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142296.3 → NP_650553.1  Derlin-2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650553.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEU2
    Related
    FBpp0082758
    Conserved Domains (1) summary
    pfam04511
    Location:11 → 201
    DER1; Der1-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VEU2 Q9VEU2

Gene LinkOut

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