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sxe2 sex-specific enzyme 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41954, updated on 4-Apr-2024

Summary

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Official Symbol
sxe2provided by FlyBase
Official Full Name
sex-specific enzyme 2provided by FlyBase
Primary source
FLYBASE:FBgn0038398
Locus tag
Dmel_CG4979
See related
AllianceGenome:FB:FBgn0038398
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4979; Dmel\CG4979; Sxe2
Summary
Enables serine hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Is expressed in adult fat body. Human ortholog(s) of this gene implicated in hypotrichosis 7. Orthologous to human LIPH (lipase H); LIPI (lipase I); and PLA1A (phospholipase A1 member A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
89B2-89B3; 3-58 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16083878..16087222)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11909600..11912944)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mini spindles Neighboring gene uncharacterized protein Neighboring gene Myosin heavy chain-like Neighboring gene uncharacterized protein Neighboring gene Akt kinase Neighboring gene Stubble Neighboring gene MICOS subunit 26/27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of function in the Drosophila clock gene period results in altered intermediary lipid metabolism and increased susceptibility to starvation. Schäbler S, et al. Cell Mol Life Sci, 2020 Dec. PMID 31960114, Free PMC Article
  2. Circadian and feeding cues integrate to drive rhythms of physiology in Drosophila insulin-producing cells. Barber AF, et al. Genes Dev, 2016 Dec 1. PMID 27979876, Free PMC Article
  3. Anomalies in the expression profile of interspecific hybrids of Drosophila melanogaster and Drosophila simulans. Ranz JM, et al. Genome Res, 2004 Mar. PMID 14962989, Free PMC Article
  4. Short exposure to nitenpyram pesticide induces effects on reproduction, development and metabolic gene expression profiles in Drosophila melanogaster (Diptera: Drosophilidae). Ahmed MAI, et al. Sci Total Environ, 2022 Jan 15. PMID 34798758, Free PMC Article
  5. Hazardous effects of octopamine receptor agonists on altering metabolism-related genes and behavior of Drosophila melanogaster. Ahmed MAI, et al. Chemosphere, 2020 Aug. PMID 32283422, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine hydrolase activity HDA PubMed 
enables triglyceride lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sex-specific enzyme 2
Names
CG4979-PA
CG4979-PB
male sex-specific enzyme 2
sxe2-PA
sxe2-PB
NP_001287352.1
NP_650522.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16083878..16087222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300423.1 → NP_001287352.1  sex-specific enzyme 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287352.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEY9
    Conserved Domains (2) summary
    cd00707
    Location:72 → 356
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    pfam00151
    Location:53 → 360
    Lipase; Lipase

  2. NM_142265.3 → NP_650522.1  sex-specific enzyme 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650522.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEY9
    Related
    FBpp0082679
    Conserved Domains (2) summary
    cd00707
    Location:72 → 356
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    pfam00151
    Location:53 → 360
    Lipase; Lipase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VEY9 Q9VEY9

Gene LinkOut

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Tools
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