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MBD1 methyl-CpG binding domain protein 1 [ Homo sapiens (human) ]

Gene ID: 4152, updated on 11-Apr-2024

Summary

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Official Symbol
MBD1provided by HGNC
Official Full Name
methyl-CpG binding domain protein 1provided by HGNC
Primary source
HGNC:HGNC:6916
See related
Ensembl:ENSG00000141644 MIM:156535; AllianceGenome:HGNC:6916
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RFT; PCM1; CXXC3
Summary
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in testis (RPKM 18.8), bone marrow (RPKM 9.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See MBD1 in Genome Data Viewer
Location:
18q21.1
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (50266885..50281767, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (50468627..50483509, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47793255..47808137, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 310, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13313 Neighboring gene cilia and flagella associated protein 53 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:47766185-47767384 Neighboring gene uncharacterized LOC124904300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:47792269-47793114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:47801678-47802178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9456 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9457 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47807971-47808551 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47808552-47809132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13320 Neighboring gene CXXC finger protein 1 Neighboring gene uncharacterized LOC124904301

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CpG dinucleotide positioning patterns determine the binding affinity of methyl-binding domain to nucleosomes. Mendonca A, et al. Biochim Biophys Acta Gene Regul Mech, 2017 Jun. PMID 28377300
  2. Molecular dynamics study of the recognition of dimethylated CpG sites by MBD1 protein. Bianchi C, et al. J Chem Inf Model, 2015 Mar 23. PMID 25658035
  3. Silencing of MBD1 reverses pancreatic cancer therapy resistance through inhibition of DNA damage repair. Xu J, et al. Int J Oncol, 2013 Jun. PMID 23588667
  4. Up-regulation of MBD1 promotes pancreatic cancer cell epithelial-mesenchymal transition and invasion by epigenetic down-regulation of E-cadherin. Xu J, et al. Curr Mol Med, 2013 Mar. PMID 23331011
  5. MeCP2: structure and function. Adkins NL, et al. Biochem Cell Biol, 2011 Feb. PMID 21326358

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZEB1 silenced SIRT3 expression via interaction with MBD1 to promote aerobic glycolysis in pancreatic cancer.
    Title: Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer.
  2. MBD1 may be a tumor suppressor gene in advanced colorectal cancer (CRC)and affect the development and metastasis of CRC by regulating 8 tumor suppressor genes through binding with SP1.
    Title: Screening of Tumor Suppressor Genes in Metastatic Colorectal Cancer.
  3. Our findings imply that reduced stability and enhanced dynamics of MBD1 or MBD6 is the origin of ATP7B dysfunction in Wilson disease patients with the G85V or G591D mutation.
    Title: Disease-causing point-mutations in metal-binding domains of Wilson disease protein decrease stability and increase structural dynamics.
  4. MBD1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner.
    Title: Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner.
  5. the binding of MBD1 to nucleosomes demonstrates sequence preferences depending on the position of the methyl groups on the nucleosome.
    Title: CpG dinucleotide positioning patterns determine the binding affinity of methyl-binding domain to nucleosomes.
  6. c-myc plays a key role in MBD1 mediated epigenetic silencing of KEAP1.
    Title: MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer.
  7. Molecular dynamic simulation reveals mechanism of the recognition of dimethylated CpG sites by MBD1 protein.
    Title: Molecular dynamics study of the recognition of dimethylated CpG sites by MBD1 protein.
  8. MBD1 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.
    Title: SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation.
  9. This study investigates the genetic association between methyl-CpG-binding domain (MBD) gene polymorphisms and schizophrenia.
    Title: Genetic association study between methyl-CpG-binding domain genes and schizophrenia among Chinese family trios.
  10. We demonstrated the importance of Aire's interaction with the ATF7ip-MBD1 protein complex in maintaining central tolerance
    Title: The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded methylated DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyl-CpG binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyl-CpG binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unmethylated CpG binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to cocaine IEA
Inferred from Electronic Annotation
more info
  
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
  
involved_in response to nutrient levels IEA
Inferred from Electronic Annotation
more info
  
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in ventricular cardiac muscle tissue development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
methyl-CpG-binding domain protein 1
Names
CXXC-type zinc finger protein 3
protein containing MBD 1
protein containing methyl-CpG-binding domain 1
the regulator of fibroblast growth factor 2 (FGF-2) transcription

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029505.1 RefSeqGene

    Range
    5252..17929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204136.2 → NP_001191065.1  methyl-CpG-binding domain protein 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks the penultimate exon compared to variant 1. This results in a frame-shift, and a longer isoform (6) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AJ564845, AK225889, AK291519, AK302004, CD723822
    Consensus CDS
    CCDS59320.1
    UniProtKB/TrEMBL
    A8K654
    Related
    ENSP00000468785.1, ENST00000590208.5
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331 → 377
    zf-CXXC; CXXC zinc finger domain

  2. NM_001204137.2 → NP_001191066.1  methyl-CpG-binding domain protein 1 isoform 7

    See identical proteins and their annotated locations for NP_001191066.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains an additional in-frame coding exon, and has a different 3' UTR compared to variant 1. This results in a longer isoform (7, also known as RFT-A) with an extra protein segment not found in isoform 1. This isoform has been shown to repress FGF-2 expression at the transcriptional level, and may be involved in FGF-2-dependent tumor progression (PMID:10187827).
    Source sequence(s)
    AC090246, AK291519, AK295401, AK302004, BP384783
    Consensus CDS
    CCDS56073.1
    UniProtKB/TrEMBL
    A8K654
    Related
    ENSP00000405268.2, ENST00000457839.6
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356 → 402
    zf-CXXC; CXXC zinc finger domain

  3. NM_001204138.2 → NP_001191067.1  methyl-CpG-binding domain protein 1 isoform 8

    See identical proteins and their annotated locations for NP_001191067.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) is the same as variant 7, except uses an alternate acceptor splice site at one of the coding exons, resulting in an isoform (8, also known as RFT-Aprime) that is 1 aa shorter than isoform 7. Unlike isoform 7, this isoform fails to bind FGF-2 promoter and repress FGF-2 gene expression (PMID:10187827).
    Source sequence(s)
    AC090246, AK291519, AK295401, AK302004, BP384783
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356 → 402
    zf-CXXC; CXXC zinc finger domain

  4. NM_001204139.2 → NP_001191068.1  methyl-CpG-binding domain protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001191068.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) contains an alternate 3' terminal non-coding exon, thus has a different 3' UTR compared to variant 1. Variants 1 and 14 encode the same isoform (1).
    Source sequence(s)
    AK291519, AK302004, BC047353
    Consensus CDS
    CCDS11943.1
    UniProtKB/Swiss-Prot
    A4UTZ0, B4DXJ5, E9PEC5, K7ELI2, K7EQZ4, K7ESN0, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UIS9, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9
    UniProtKB/TrEMBL
    A8K654
    Related
    ENSP00000372407.5, ENST00000382948.9
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331 → 377
    zf-CXXC; CXXC zinc finger domain

  5. NM_001204140.2 → NP_001191069.1  methyl-CpG-binding domain protein 1 isoform 9

    See identical proteins and their annotated locations for NP_001191069.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) is the same as variant 7, except lacks an in-frame coding exon, resulting in an isoform (9, also known as RFT-B) that is missing an internal protein segment compared to isoform 7. Unlike isoform 7, this isoform fails to bind FGF-2 promoter and repress FGF-2 gene expression (PMID:10187827).
    Source sequence(s)
    AC090246, AK291519, AK295401, AK302004, BP384783
    UniProtKB/TrEMBL
    A0A0A0MS90
    Related
    ENSP00000381508.2, ENST00000398495.6
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  6. NM_001204141.2 → NP_001191070.1  methyl-CpG-binding domain protein 1 isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks 2 non-consecutive coding exons, and contains an alternate 3' terminal exon compared to variant 1. This results in a frame-shift in the 3' coding region, and a shorter isoform (10) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK225889, AK291519, AK302004, BC047353
    Consensus CDS
    CCDS59318.1
    UniProtKB/TrEMBL
    A8K654
    Related
    ENSP00000466092.1, ENST00000585672.5
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:281 → 327
    zf-CXXC; CXXC zinc finger domain

  7. NM_001204142.2 → NP_001191071.1  methyl-CpG-binding domain protein 1 isoform 11

    See identical proteins and their annotated locations for NP_001191071.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks 3 non-consecutive coding exons, and uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift in the 3' coding region, and a shorter isoform (11) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF078831, AJ564845, AK291519, CD723822
    Consensus CDS
    CCDS56072.1
    UniProtKB/TrEMBL
    A8K654
    Related
    ENSP00000339546.5, ENST00000339998.10
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331 → 377
    zf-CXXC; CXXC zinc finger domain

  8. NM_001204143.2 → NP_001191072.1  methyl-CpG-binding domain protein 1 isoform 12

    See identical proteins and their annotated locations for NP_001191072.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) lacks 3 non-consecutive coding exons, and uses an alternate donor splice site at the 5' non-coding exon and an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift in the 3' coding region, and a shorter isoform (12) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF078831, AJ564845, AK300759, CD723822
    Consensus CDS
    CCDS59319.1
    UniProtKB/TrEMBL
    B4DUR3
    Related
    ENSP00000468042.1, ENST00000587605.5
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  9. NM_001204151.3 → NP_001191080.1  methyl-CpG-binding domain protein 1 isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) lacks 2 non-consecutive in-frame coding exons compared to variant 1. This results in a shorter isoform (13) missing two internal protein segments compared to isoform 1.
    Source sequence(s)
    AC090246
    Consensus CDS
    CCDS56071.1
    UniProtKB/TrEMBL
    A8K654
    Related
    ENSP00000465923.1, ENST00000591535.5
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:308 → 354
    zf-CXXC; CXXC zinc finger domain

  10. NM_001323942.2 → NP_001310871.1  methyl-CpG-binding domain protein 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC090246
    Consensus CDS
    CCDS92462.1
    UniProtKB/TrEMBL
    A0A994J7H0, A8K654
    Related
    ENSP00000516153.1, ENST00000705655.1
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356 → 402
    zf-CXXC; CXXC zinc finger domain

  11. NM_001323947.2 → NP_001310876.1  methyl-CpG-binding domain protein 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356 → 402
    zf-CXXC; CXXC zinc finger domain

  12. NM_001323949.2 → NP_001310878.1  methyl-CpG-binding domain protein 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC090246

  13. NM_001323950.2 → NP_001310879.1  methyl-CpG-binding domain protein 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654

  14. NM_001323951.2 → NP_001310880.1  methyl-CpG-binding domain protein 1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654

  15. NM_001323952.2 → NP_001310881.1  methyl-CpG-binding domain protein 1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A0A0A0MS90

  16. NM_001323953.2 → NP_001310882.1  methyl-CpG-binding domain protein 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC090246

  17. NM_001323954.2 → NP_001310883.1  methyl-CpG-binding domain protein 1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A0A0A0MS90
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  18. NM_001388138.1 → NP_001375067.1  methyl-CpG-binding domain protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC090246
    Consensus CDS
    CCDS11943.1
    UniProtKB/Swiss-Prot
    A4UTZ0, B4DXJ5, E9PEC5, K7ELI2, K7EQZ4, K7ESN0, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UIS9, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331 → 377
    zf-CXXC; CXXC zinc finger domain

  19. NM_001388139.1 → NP_001375068.1  methyl-CpG-binding domain protein 1 isoform 42

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A0A0A0MS90
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  20. NM_001388140.1 → NP_001375069.1  methyl-CpG-binding domain protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090246
    Consensus CDS
    CCDS56073.1
    UniProtKB/TrEMBL
    A8K654
    Related
    ENSP00000468430.1, ENST00000585595.5
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356 → 402
    zf-CXXC; CXXC zinc finger domain

  21. NM_001388141.1 → NP_001375070.1  methyl-CpG-binding domain protein 1 isoform 43

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:355 → 401
    zf-CXXC; CXXC zinc finger domain

  22. NM_001388142.1 → NP_001375071.1  methyl-CpG-binding domain protein 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A0A0A0MS90
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  23. NM_001388143.1 → NP_001375072.1  methyl-CpG-binding domain protein 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A0A0A0MS90
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  24. NM_001388144.1 → NP_001375073.1  methyl-CpG-binding domain protein 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC090246
    Consensus CDS
    CCDS59319.1
    UniProtKB/TrEMBL
    B4DUR3
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  25. NM_001388145.1 → NP_001375074.1  methyl-CpG-binding domain protein 1 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356 → 402
    zf-CXXC; CXXC zinc finger domain

  26. NM_001388146.1 → NP_001375075.1  methyl-CpG-binding domain protein 1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356 → 402
    zf-CXXC; CXXC zinc finger domain

  27. NM_001388147.1 → NP_001375076.1  methyl-CpG-binding domain protein 1 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356 → 402
    zf-CXXC; CXXC zinc finger domain

  28. NM_001388148.1 → NP_001375077.1  methyl-CpG-binding domain protein 1 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331 → 377
    zf-CXXC; CXXC zinc finger domain

  29. NM_001388149.1 → NP_001375078.1  methyl-CpG-binding domain protein 1 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331 → 377
    zf-CXXC; CXXC zinc finger domain

  30. NM_001388150.1 → NP_001375079.1  methyl-CpG-binding domain protein 1 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356 → 402
    zf-CXXC; CXXC zinc finger domain

  31. NM_001388151.1 → NP_001375080.1  methyl-CpG-binding domain protein 1 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A0A0A0MS90
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  32. NM_001388152.1 → NP_001375081.1  methyl-CpG-binding domain protein 1 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    B4DUR3
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356 → 402
    zf-CXXC; CXXC zinc finger domain

  33. NM_001388153.1 → NP_001375082.1  methyl-CpG-binding domain protein 1 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356 → 402
    zf-CXXC; CXXC zinc finger domain

  34. NM_001388154.1 → NP_001375083.1  methyl-CpG-binding domain protein 1 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356 → 402
    zf-CXXC; CXXC zinc finger domain

  35. NM_001388155.1 → NP_001375084.1  methyl-CpG-binding domain protein 1 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331 → 377
    zf-CXXC; CXXC zinc finger domain

  36. NM_001388156.1 → NP_001375085.1  methyl-CpG-binding domain protein 1 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A0A0A0MS90
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  37. NM_001388157.1 → NP_001375086.1  methyl-CpG-binding domain protein 1 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A0A0A0MS90
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  38. NM_001388158.1 → NP_001375087.1  methyl-CpG-binding domain protein 1 isoform 34

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356 → 402
    zf-CXXC; CXXC zinc finger domain

  39. NM_001388159.1 → NP_001375088.1  methyl-CpG-binding domain protein 1 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356 → 402
    zf-CXXC; CXXC zinc finger domain

  40. NM_001388160.1 → NP_001375089.1  methyl-CpG-binding domain protein 1 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356 → 402
    zf-CXXC; CXXC zinc finger domain

  41. NM_001388161.1 → NP_001375090.1  methyl-CpG-binding domain protein 1 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    B4DUR3
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  42. NM_001388162.1 → NP_001375091.1  methyl-CpG-binding domain protein 1 isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331 → 377
    zf-CXXC; CXXC zinc finger domain

  43. NM_001388163.1 → NP_001375092.1  methyl-CpG-binding domain protein 1 isoform 44

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331 → 377
    zf-CXXC; CXXC zinc finger domain

  44. NM_001388164.1 → NP_001375093.1  methyl-CpG-binding domain protein 1 isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A0A0A0MS90
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  45. NM_001388165.1 → NP_001375094.1  methyl-CpG-binding domain protein 1 isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A0A0A0MS90
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  46. NM_001388166.1 → NP_001375095.1  methyl-CpG-binding domain protein 1 isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    A0A0A0MS90
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  47. NM_001388167.1 → NP_001375096.1  methyl-CpG-binding domain protein 1 isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    B4DUR3
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  48. NM_001399879.1 → NP_001386808.1  methyl-CpG-binding domain protein 1 isoform 45

    Status: REVIEWED

    Source sequence(s)
    AC090246

  49. NM_001399880.1 → NP_001386809.1  methyl-CpG-binding domain protein 1 isoform 46

    Status: REVIEWED

    Source sequence(s)
    AC090246
    UniProtKB/TrEMBL
    B4DI41

  50. NM_001399881.1 → NP_001386810.1  methyl-CpG-binding domain protein 1 isoform 47

    Status: REVIEWED

    Source sequence(s)
    AC090246

  51. NM_001399882.1 → NP_001386811.1  methyl-CpG-binding domain protein 1 isoform 48

    Status: REVIEWED

    Source sequence(s)
    AC090246

  52. NM_001399883.1 → NP_001386812.1  methyl-CpG-binding domain protein 1 isoform 49

    Status: REVIEWED

    Source sequence(s)
    AC090246

  53. NM_001399884.1 → NP_001386813.1  methyl-CpG-binding domain protein 1 isoform 50

    Status: REVIEWED

    Source sequence(s)
    AC090246

  54. NM_001399885.1 → NP_001386814.1  methyl-CpG-binding domain protein 1 isoform 51

    Status: REVIEWED

    Source sequence(s)
    AC090246

  55. NM_001399886.1 → NP_001386815.1  methyl-CpG-binding domain protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090246
    Consensus CDS
    CCDS56073.1

  56. NM_001399887.1 → NP_001386816.1  methyl-CpG-binding domain protein 1 isoform 52

    Status: REVIEWED

    Source sequence(s)
    AC090246

  57. NM_001399888.1 → NP_001386817.1  methyl-CpG-binding domain protein 1 isoform 43

    Status: REVIEWED

    Source sequence(s)
    AC090246

  58. NM_001399889.1 → NP_001386818.1  methyl-CpG-binding domain protein 1 isoform 53

    Status: REVIEWED

    Source sequence(s)
    AC090246

  59. NM_001399890.1 → NP_001386819.1  methyl-CpG-binding domain protein 1 isoform 54

    Status: REVIEWED

    Source sequence(s)
    AC090246

  60. NM_001399891.1 → NP_001386820.1  methyl-CpG-binding domain protein 1 isoform 55

    Status: REVIEWED

    Source sequence(s)
    AC090246

  61. NM_001399892.1 → NP_001386821.1  methyl-CpG-binding domain protein 1 isoform 56

    Status: REVIEWED

    Source sequence(s)
    AC090246

  62. NM_001399893.1 → NP_001386822.1  methyl-CpG-binding domain protein 1 isoform 57

    Status: REVIEWED

    Source sequence(s)
    AC090246

  63. NM_001399894.1 → NP_001386823.1  methyl-CpG-binding domain protein 1 isoform 58

    Status: REVIEWED

    Source sequence(s)
    AC090246

  64. NM_001399895.1 → NP_001386824.1  methyl-CpG-binding domain protein 1 isoform 59

    Status: REVIEWED

    Source sequence(s)
    AC090246

  65. NM_001399896.1 → NP_001386825.1  methyl-CpG-binding domain protein 1 isoform 60

    Status: REVIEWED

    Source sequence(s)
    AC090246

  66. NM_001399897.1 → NP_001386826.1  methyl-CpG-binding domain protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC090246
    Consensus CDS
    CCDS11943.1
    UniProtKB/Swiss-Prot
    A4UTZ0, B4DXJ5, E9PEC5, K7ELI2, K7EQZ4, K7ESN0, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UIS9, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9

  67. NM_001399898.1 → NP_001386827.1  methyl-CpG-binding domain protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC090246
    Consensus CDS
    CCDS11943.1
    UniProtKB/Swiss-Prot
    A4UTZ0, B4DXJ5, E9PEC5, K7ELI2, K7EQZ4, K7ESN0, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UIS9, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9

  68. NM_001399899.1 → NP_001386828.1  methyl-CpG-binding domain protein 1 isoform 61

    Status: REVIEWED

    Source sequence(s)
    AC090246

  69. NM_001399900.1 → NP_001386829.1  methyl-CpG-binding domain protein 1 isoform 61

    Status: REVIEWED

    Source sequence(s)
    AC090246

  70. NM_001399901.1 → NP_001386830.1  methyl-CpG-binding domain protein 1 isoform 61

    Status: REVIEWED

    Source sequence(s)
    AC090246

  71. NM_001399902.1 → NP_001386831.1  methyl-CpG-binding domain protein 1 isoform 61

    Status: REVIEWED

    Source sequence(s)
    AC090246

  72. NM_001399903.1 → NP_001386832.1  methyl-CpG-binding domain protein 1 isoform 62

    Status: REVIEWED

    Source sequence(s)
    AC090246

  73. NM_001399904.1 → NP_001386833.1  methyl-CpG-binding domain protein 1 isoform 63

    Status: REVIEWED

    Source sequence(s)
    AC090246

  74. NM_001399905.1 → NP_001386834.1  methyl-CpG-binding domain protein 1 isoform 64

    Status: REVIEWED

    Source sequence(s)
    AC090246

  75. NM_001399906.1 → NP_001386835.1  methyl-CpG-binding domain protein 1 isoform 65

    Status: REVIEWED

    Source sequence(s)
    AC090246

  76. NM_001399907.1 → NP_001386836.1  methyl-CpG-binding domain protein 1 isoform 66

    Status: REVIEWED

    Source sequence(s)
    AC090246

  77. NM_001399908.1 → NP_001386837.1  methyl-CpG-binding domain protein 1 isoform 67

    Status: REVIEWED

    Source sequence(s)
    AC090246

  78. NM_001399909.1 → NP_001386838.1  methyl-CpG-binding domain protein 1 isoform 68

    Status: REVIEWED

    Source sequence(s)
    AC090246

  79. NM_001399910.1 → NP_001386839.1  methyl-CpG-binding domain protein 1 isoform 69

    Status: REVIEWED

    Source sequence(s)
    AC090246

  80. NM_001399911.1 → NP_001386840.1  methyl-CpG-binding domain protein 1 isoform 70

    Status: REVIEWED

    Source sequence(s)
    AC090246

  81. NM_001399912.1 → NP_001386841.1  methyl-CpG-binding domain protein 1 isoform 70

    Status: REVIEWED

    Source sequence(s)
    AC090246

  82. NM_001399913.1 → NP_001386842.1  methyl-CpG-binding domain protein 1 isoform 70

    Status: REVIEWED

    Source sequence(s)
    AC090246

  83. NM_001399914.1 → NP_001386843.1  methyl-CpG-binding domain protein 1 isoform 70

    Status: REVIEWED

    Source sequence(s)
    AC090246

  84. NM_001399915.1 → NP_001386844.1  methyl-CpG-binding domain protein 1 isoform 120

    Status: REVIEWED

    Source sequence(s)
    AC090246

  85. NM_001399916.1 → NP_001386845.1  methyl-CpG-binding domain protein 1 isoform 71

    Status: REVIEWED

    Source sequence(s)
    AC090246

  86. NM_001399917.1 → NP_001386846.1  methyl-CpG-binding domain protein 1 isoform 72

    Status: REVIEWED

    Source sequence(s)
    AC090246

  87. NM_001399918.1 → NP_001386847.1  methyl-CpG-binding domain protein 1 isoform 73

    Status: REVIEWED

    Source sequence(s)
    AC090246

  88. NM_001399919.1 → NP_001386848.1  methyl-CpG-binding domain protein 1 isoform 74

    Status: REVIEWED

    Source sequence(s)
    AC090246

  89. NM_001399920.1 → NP_001386849.1  methyl-CpG-binding domain protein 1 isoform 75

    Status: REVIEWED

    Source sequence(s)
    AC090246

  90. NM_001399921.1 → NP_001386850.1  methyl-CpG-binding domain protein 1 isoform 76

    Status: REVIEWED

    Source sequence(s)
    AC090246

  91. NM_001399922.1 → NP_001386851.1  methyl-CpG-binding domain protein 1 isoform 77

    Status: REVIEWED

    Source sequence(s)
    AC090246

  92. NM_001399923.1 → NP_001386852.1  methyl-CpG-binding domain protein 1 isoform 78

    Status: REVIEWED

    Source sequence(s)
    AC090246

  93. NM_001399924.1 → NP_001386853.1  methyl-CpG-binding domain protein 1 isoform 79

    Status: REVIEWED

    Source sequence(s)
    AC090246

  94. NM_001399925.1 → NP_001386854.1  methyl-CpG-binding domain protein 1 isoform 80

    Status: REVIEWED

    Source sequence(s)
    AC090246

  95. NM_001399926.1 → NP_001386855.1  methyl-CpG-binding domain protein 1 isoform 81

    Status: REVIEWED

    Source sequence(s)
    AC090246

  96. NM_001399927.1 → NP_001386856.1  methyl-CpG-binding domain protein 1 isoform 82

    Status: REVIEWED

    Source sequence(s)
    AC090246

  97. NM_001399928.1 → NP_001386857.1  methyl-CpG-binding domain protein 1 isoform 83

    Status: REVIEWED

    Source sequence(s)
    AC090246

  98. NM_001399929.1 → NP_001386858.1  methyl-CpG-binding domain protein 1 isoform 84

    Status: REVIEWED

    Source sequence(s)
    AC090246

  99. NM_001399930.1 → NP_001386859.1  methyl-CpG-binding domain protein 1 isoform 85

    Status: REVIEWED

    Source sequence(s)
    AC090246

  100. NM_001399931.1 → NP_001386860.1  methyl-CpG-binding domain protein 1 isoform 86

    Status: REVIEWED

    Source sequence(s)
    AC090246

  101. NM_001399932.1 → NP_001386861.1  methyl-CpG-binding domain protein 1 isoform 87

    Status: REVIEWED

    Source sequence(s)
    AC090246

  102. NM_001399933.1 → NP_001386862.1  methyl-CpG-binding domain protein 1 isoform 88

    Status: REVIEWED

    Source sequence(s)
    AC090246

  103. NM_001399934.1 → NP_001386863.1  methyl-CpG-binding domain protein 1 isoform 44

    Status: REVIEWED

    Source sequence(s)
    AC090246

  104. NM_001399935.1 → NP_001386864.1  methyl-CpG-binding domain protein 1 isoform 89

    Status: REVIEWED

    Source sequence(s)
    AC090246

  105. NM_001399936.1 → NP_001386865.1  methyl-CpG-binding domain protein 1 isoform 90

    Status: REVIEWED

    Source sequence(s)
    AC090246

  106. NM_001399937.1 → NP_001386866.1  methyl-CpG-binding domain protein 1 isoform 91

    Status: REVIEWED

    Source sequence(s)
    AC090246

  107. NM_001399938.1 → NP_001386867.1  methyl-CpG-binding domain protein 1 isoform 92

    Status: REVIEWED

    Source sequence(s)
    AC090246

  108. NM_001399939.1 → NP_001386868.1  methyl-CpG-binding domain protein 1 isoform 93

    Status: REVIEWED

    Source sequence(s)
    AC090246

  109. NM_001399940.1 → NP_001386869.1  methyl-CpG-binding domain protein 1 isoform 93

    Status: REVIEWED

    Source sequence(s)
    AC090246

  110. NM_001399941.1 → NP_001386870.1  methyl-CpG-binding domain protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC090246
    Consensus CDS
    CCDS11942.1

  111. NM_001399942.1 → NP_001386871.1  methyl-CpG-binding domain protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC090246
    Consensus CDS
    CCDS11942.1

  112. NM_001399943.1 → NP_001386872.1  methyl-CpG-binding domain protein 1 isoform 94

    Status: REVIEWED

    Source sequence(s)
    AC090246

  113. NM_001399944.1 → NP_001386873.1  methyl-CpG-binding domain protein 1 isoform 95

    Status: REVIEWED

    Source sequence(s)
    AC090246

  114. NM_001399945.1 → NP_001386874.1  methyl-CpG-binding domain protein 1 isoform 96

    Status: REVIEWED

    Source sequence(s)
    AC090246

  115. NM_001399946.1 → NP_001386875.1  methyl-CpG-binding domain protein 1 isoform 97

    Status: REVIEWED

    Source sequence(s)
    AC090246

  116. NM_001399947.1 → NP_001386876.1  methyl-CpG-binding domain protein 1 isoform 98

    Status: REVIEWED

    Source sequence(s)
    AC090246

  117. NM_001399948.1 → NP_001386877.1  methyl-CpG-binding domain protein 1 isoform 98

    Status: REVIEWED

    Source sequence(s)
    AC090246

  118. NM_001399949.1 → NP_001386878.1  methyl-CpG-binding domain protein 1 isoform 99

    Status: REVIEWED

    Source sequence(s)
    AC090246

  119. NM_001399950.1 → NP_001386879.1  methyl-CpG-binding domain protein 1 isoform 100

    Status: REVIEWED

    Source sequence(s)
    AC090246

  120. NM_001399952.1 → NP_001386881.1  methyl-CpG-binding domain protein 1 isoform 101

    Status: REVIEWED

    Source sequence(s)
    AC090246

  121. NM_001399953.1 → NP_001386882.1  methyl-CpG-binding domain protein 1 isoform 102

    Status: REVIEWED

    Source sequence(s)
    AC090246

  122. NM_001399954.1 → NP_001386883.1  methyl-CpG-binding domain protein 1 isoform 103

    Status: REVIEWED

    Source sequence(s)
    AC090246

  123. NM_001399955.1 → NP_001386884.1  methyl-CpG-binding domain protein 1 isoform 104

    Status: REVIEWED

    Source sequence(s)
    AC090246

  124. NM_001399956.1 → NP_001386885.1  methyl-CpG-binding domain protein 1 isoform 105

    Status: REVIEWED

    Source sequence(s)
    AC090246

  125. NM_001399957.1 → NP_001386886.1  methyl-CpG-binding domain protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC090246
    Consensus CDS
    CCDS11941.1
    Related
    ENSP00000381502.1, ENST00000398488.5

  126. NM_001399958.1 → NP_001386887.1  methyl-CpG-binding domain protein 1 isoform 106

    Status: REVIEWED

    Source sequence(s)
    AC090246

  127. NM_001399959.1 → NP_001386888.1  methyl-CpG-binding domain protein 1 isoform 107

    Status: REVIEWED

    Source sequence(s)
    AC090246

  128. NM_001399960.1 → NP_001386889.1  methyl-CpG-binding domain protein 1 isoform 108

    Status: REVIEWED

    Source sequence(s)
    AC090246

  129. NM_001399961.1 → NP_001386890.1  methyl-CpG-binding domain protein 1 isoform 109

    Status: REVIEWED

    Source sequence(s)
    AC090246

  130. NM_001399962.1 → NP_001386891.1  methyl-CpG-binding domain protein 1 isoform 110

    Status: REVIEWED

    Source sequence(s)
    AC090246

  131. NM_001399963.1 → NP_001386892.1  methyl-CpG-binding domain protein 1 isoform 111

    Status: REVIEWED

    Source sequence(s)
    AC090246

  132. NM_001399964.1 → NP_001386893.1  methyl-CpG-binding domain protein 1 isoform 111

    Status: REVIEWED

    Source sequence(s)
    AC090246

  133. NM_001399965.1 → NP_001386894.1  methyl-CpG-binding domain protein 1 isoform 112

    Status: REVIEWED

    Source sequence(s)
    AC090246

  134. NM_001399966.1 → NP_001386895.1  methyl-CpG-binding domain protein 1 isoform 113

    Status: REVIEWED

    Source sequence(s)
    AC090246

  135. NM_001399967.1 → NP_001386896.1  methyl-CpG-binding domain protein 1 isoform 114

    Status: REVIEWED

    Source sequence(s)
    AC090246

  136. NM_001399968.1 → NP_001386897.1  methyl-CpG-binding domain protein 1 isoform 114

    Status: REVIEWED

    Source sequence(s)
    AC090246

  137. NM_001399970.1 → NP_001386899.1  methyl-CpG-binding domain protein 1 isoform 114

    Status: REVIEWED

    Source sequence(s)
    AC090246

  138. NM_001399971.1 → NP_001386900.1  methyl-CpG-binding domain protein 1 isoform 115

    Status: REVIEWED

    Source sequence(s)
    AC090246

  139. NM_001399973.1 → NP_001386902.1  methyl-CpG-binding domain protein 1 isoform 116

    Status: REVIEWED

    Source sequence(s)
    AC090246

  140. NM_001399974.1 → NP_001386903.1  methyl-CpG-binding domain protein 1 isoform 117

    Status: REVIEWED

    Source sequence(s)
    AC090246

  141. NM_001399975.1 → NP_001386904.1  methyl-CpG-binding domain protein 1 isoform 118

    Status: REVIEWED

    Source sequence(s)
    AC090246

  142. NM_001399976.1 → NP_001386905.1  methyl-CpG-binding domain protein 1 isoform 119

    Status: REVIEWED

    Source sequence(s)
    AC090246

  143. NM_002384.3 → NP_002375.1  methyl-CpG-binding domain protein 1 isoform 4

    See identical proteins and their annotated locations for NP_002375.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks 2 in-frame non-consecutive coding exons compared to variant 1, resulting in a shorter isoform (4) missing two internal protein segments compared to isoform 1.
    Source sequence(s)
    AJ564845, AK225948, BC033242, DC403953
    Consensus CDS
    CCDS11941.1
    UniProtKB/TrEMBL
    B4DUR3
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  144. NM_015844.3 → NP_056669.2  methyl-CpG-binding domain protein 1 isoform 3

    See identical proteins and their annotated locations for NP_056669.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (3) missing an internal protein segment compared to isoform 1. Variants 1, 118, and 119 all encode the same isoform (3).
    Source sequence(s)
    AJ564845, AK225948, BC033242, DC403953
    Consensus CDS
    CCDS11942.1
    UniProtKB/TrEMBL
    A0A0A0MS90
    Related
    ENSP00000285102.5, ENST00000347968.7
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  145. NM_015845.4 → NP_056670.2  methyl-CpG-binding domain protein 1 isoform 2

    See identical proteins and their annotated locations for NP_056670.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing 3 non-consecutive coding exons compared to variant 1, the last of which causes a frame-shift. This results in a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AJ564845, AK225889, AK225948, BC033242, DC403953
    Consensus CDS
    CCDS32832.1
    UniProtKB/TrEMBL
    B4DUR3
    Related
    ENSP00000269471.5, ENST00000269471.9
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:308 → 354
    zf-CXXC; CXXC zinc finger domain

  146. NM_015846.4 → NP_056671.2  methyl-CpG-binding domain protein 1 isoform 1

    See identical proteins and their annotated locations for NP_056671.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1. Variants 1 and 14 encode the same isoform.
    Source sequence(s)
    AJ564845, AK225889, AK225948, BC033242, DC403953
    Consensus CDS
    CCDS11943.1
    UniProtKB/Swiss-Prot
    A4UTZ0, B4DXJ5, E9PEC5, K7ELI2, K7EQZ4, K7ESN0, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UIS9, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9
    UniProtKB/TrEMBL
    A8K654
    Related
    ENSP00000269468.5, ENST00000269468.10
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331 → 377
    zf-CXXC; CXXC zinc finger domain

  147. NM_015847.4 → NP_056723.2  methyl-CpG-binding domain protein 1 isoform 5

    See identical proteins and their annotated locations for NP_056723.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (5) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AJ564845, AK225889, AK225948, BC033242, DC403953
    Consensus CDS
    CCDS11944.1
    UniProtKB/TrEMBL
    A8K654
    Related
    ENSP00000269469.5, ENST00000353909.7
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:282 → 328
    zf-CXXC; CXXC zinc finger domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    50266885..50281767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437514.1 → XP_047293470.1  methyl-CpG-binding domain protein 1 isoform X7

  2. XM_017025776.3 → XP_016881265.1  methyl-CpG-binding domain protein 1 isoform X18

    UniProtKB/TrEMBL
    B4DUR3
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  3. XM_047437519.1 → XP_047293475.1  methyl-CpG-binding domain protein 1 isoform X16

  4. XM_017025770.3 → XP_016881259.1  methyl-CpG-binding domain protein 1 isoform X15

    UniProtKB/TrEMBL
    A0A0A0MS90
    Related
    ENSP00000381506.1, ENST00000398493.5
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  5. XM_047437517.1 → XP_047293473.1  methyl-CpG-binding domain protein 1 isoform X10

  6. XM_047437513.1 → XP_047293469.1  methyl-CpG-binding domain protein 1 isoform X6

  7. XM_011526007.3 → XP_011524309.1  methyl-CpG-binding domain protein 1 isoform X13

    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331 → 377
    zf-CXXC; CXXC zinc finger domain

  8. XM_047437516.1 → XP_047293472.1  methyl-CpG-binding domain protein 1 isoform X9

  9. XM_005258271.4 → XP_005258328.1  methyl-CpG-binding domain protein 1 isoform X5

    See identical proteins and their annotated locations for XP_005258328.1

    UniProtKB/Swiss-Prot
    A4UTZ0, B4DXJ5, E9PEC5, K7ELI2, K7EQZ4, K7ESN0, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UIS9, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9
    UniProtKB/TrEMBL
    A8K654
    Related
    ENSP00000467017.1, ENST00000591416.5
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331 → 377
    zf-CXXC; CXXC zinc finger domain

  10. XM_047437518.1 → XP_047293474.1  methyl-CpG-binding domain protein 1 isoform X12

  11. XM_047437520.1 → XP_047293476.1  methyl-CpG-binding domain protein 1 isoform X17

  12. XM_047437515.1 → XP_047293471.1  methyl-CpG-binding domain protein 1 isoform X8

  13. XM_024451180.2 → XP_024306948.1  methyl-CpG-binding domain protein 1 isoform X14

    UniProtKB/TrEMBL
    A0A0A0MS90
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168 → 215
    zf-CXXC; CXXC zinc finger domain

  14. XM_047437512.1 → XP_047293468.1  methyl-CpG-binding domain protein 1 isoform X4

  15. XM_047437510.1 → XP_047293466.1  methyl-CpG-binding domain protein 1 isoform X1

  16. XM_047437511.1 → XP_047293467.1  methyl-CpG-binding domain protein 1 isoform X2

  17. XM_011526002.3 → XP_011524304.1  methyl-CpG-binding domain protein 1 isoform X11

    See identical proteins and their annotated locations for XP_011524304.1

    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356 → 402
    zf-CXXC; CXXC zinc finger domain

  18. XM_017025757.3 → XP_016881246.1  methyl-CpG-binding domain protein 1 isoform X3

    UniProtKB/TrEMBL
    A8K654
    Conserved Domains (2) summary
    smart00391
    Location:3 → 76
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356 → 402
    zf-CXXC; CXXC zinc finger domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    50468627..50483509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318630.1 → XP_054174605.1  methyl-CpG-binding domain protein 1 isoform X7

  2. XM_054318641.1 → XP_054174616.1  methyl-CpG-binding domain protein 1 isoform X18

  3. XM_054318639.1 → XP_054174614.1  methyl-CpG-binding domain protein 1 isoform X16

  4. XM_054318638.1 → XP_054174613.1  methyl-CpG-binding domain protein 1 isoform X15

  5. XM_054318633.1 → XP_054174608.1  methyl-CpG-binding domain protein 1 isoform X10

  6. XM_054318629.1 → XP_054174604.1  methyl-CpG-binding domain protein 1 isoform X6

  7. XM_054318636.1 → XP_054174611.1  methyl-CpG-binding domain protein 1 isoform X13

  8. XM_054318632.1 → XP_054174607.1  methyl-CpG-binding domain protein 1 isoform X9

  9. XM_054318628.1 → XP_054174603.1  methyl-CpG-binding domain protein 1 isoform X5

    UniProtKB/Swiss-Prot
    A4UTZ0, B4DXJ5, E9PEC5, K7ELI2, K7EQZ4, K7ESN0, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UIS9, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9

  10. XM_054318635.1 → XP_054174610.1  methyl-CpG-binding domain protein 1 isoform X12

  11. XM_054318640.1 → XP_054174615.1  methyl-CpG-binding domain protein 1 isoform X17

  12. XM_054318631.1 → XP_054174606.1  methyl-CpG-binding domain protein 1 isoform X8

  13. XM_054318637.1 → XP_054174612.1  methyl-CpG-binding domain protein 1 isoform X14

  14. XM_054318627.1 → XP_054174602.1  methyl-CpG-binding domain protein 1 isoform X4

  15. XM_054318624.1 → XP_054174599.1  methyl-CpG-binding domain protein 1 isoform X1

  16. XM_054318625.1 → XP_054174600.1  methyl-CpG-binding domain protein 1 isoform X2

  17. XM_054318634.1 → XP_054174609.1  methyl-CpG-binding domain protein 1 isoform X11

  18. XM_054318626.1 → XP_054174601.1  methyl-CpG-binding domain protein 1 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UIS9.2 GenPept UniProtKB/Swiss-Prot:Q9UIS9

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