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Zfp950 zinc finger protein 950 [ Mus musculus (house mouse) ]

Gene ID: 414758, updated on 3-Apr-2024

Summary

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Official Symbol
Zfp950provided by MGI
Official Full Name
zinc finger protein 950provided by MGI
Primary source
MGI:MGI:2652824
See related
Ensembl:ENSMUSG00000074733 AllianceGenome:MGI:2652824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp826; mszf84; Gm34518; 5830428H23Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; face morphogenesis; and vasculogenesis. Predicted to be active in nucleus. Is expressed in bladder; testis; and ureter. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 3.3), limb E14.5 (RPKM 2.9) and 26 other tissues See more
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Genomic context

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Location:
19 D3; 19 56.67 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (61042692..61129297, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (61053840..61140844, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene predicted gene 9529 Neighboring gene predicted gene, 22520 Neighboring gene STARR-positive B cell enhancer ABC_E10001 Neighboring gene STARR-positive B cell enhancer ABC_E9458 Neighboring gene STARR-positive B cell enhancer ABC_E7681 Neighboring gene STARR-positive B cell enhancer ABC_E1214 Neighboring gene STARR-seq mESC enhancer starr_46603 Neighboring gene STARR-seq mESC enhancer starr_46604 Neighboring gene ribosomal protein S25 pseudogene Neighboring gene predicted gene 6020 Neighboring gene predicted gene, 22365 Neighboring gene mortality factor 4 like 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PDGF signaling specificity is mediated through multiple immediate early genes. Schmahl J, et al. Nat Genet, 2007 Jan. PMID 17143286
  2. Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Suzuki A, et al. Mech Dev, 2018 Apr. PMID 29475039, Free PMC Article
  3. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
  4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within face morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nitrogen compound metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within smooth muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 950
Names
zinc finger protein 826
zinc finger prtoein 950

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001737.3 → NP_001001737.1  zinc finger protein 950 isoform c

    See identical proteins and their annotated locations for NP_001001737.1

    Status: VALIDATED

    Source sequence(s)
    AC165327
    Consensus CDS
    CCDS84461.1
    UniProtKB/TrEMBL
    A0A0U1RPH0, Q8BL88
    Related
    ENSMUSP00000145915.2, ENSMUST00000143264.8
    Conserved Domains (2) summary
    smart00349
    Location:4 → 45
    KRAB; krueppel associated box
    pfam01352
    Location:4 → 43
    KRAB; KRAB box

  2. NM_001309195.2 → NP_001296124.1  zinc finger protein 950 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC165327
    Consensus CDS
    CCDS84462.1
    UniProtKB/TrEMBL
    A0A0U1RP12, A0A0U1RPH0
    Related
    ENSMUSP00000145786.2, ENSMUST00000205854.2
    Conserved Domains (2) summary
    smart00349
    Location:4 → 45
    KRAB; krueppel associated box
    pfam01352
    Location:4 → 43
    KRAB; KRAB box

  3. NM_001309216.2 → NP_001296145.1  zinc finger protein 950 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC165327
    Consensus CDS
    CCDS84463.1
    UniProtKB/TrEMBL
    A0A0U1RQ46
    Related
    ENSMUSP00000146243.2, ENSMUST00000180544.3
    Conserved Domains (3) summary
    COG5048
    Location:101 → 514
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:133 → 153
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 44
    KRAB; KRAB box

  4. NM_001409028.1 → NP_001395957.1  zinc finger protein 950 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC161413, AC165327

RNA

  1. NR_131953.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC161413, AC165327

  2. NR_131954.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC165327
    Related
    ENSMUST00000127290.8

  3. NR_131955.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC165327

  4. NR_131956.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC165327

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    61042692..61129297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161622.1 → XP_036017515.1  zinc finger protein 950 isoform X3

    UniProtKB/TrEMBL
    A0A0U1RNP3
    Related
    ENSMUSP00000145648.2, ENSMUST00000205712.2
    Conserved Domains (2) summary
    sd00017
    Location:77 → 97
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 44
    KRAB; KRAB box

  2. XM_036161621.1 → XP_036017514.1  zinc finger protein 950 isoform X1

    UniProtKB/TrEMBL
    A0A0U1RQ46
    Conserved Domains (3) summary
    COG5048
    Location:101 → 514
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:133 → 153
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 44
    KRAB; KRAB box

  3. XM_017318246.3 → XP_017173735.1  zinc finger protein 950 isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:57 → 470
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:89 → 109
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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