PLN phospholamban [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PLNprovided by VGNC
Official Full Name: phospholambanprovided by VGNC
Primary source: VGNC:VGNC:44700
See related: Ensembl:ENSCAFG00845007035
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	1	NC_051805.1 (58763549..58775010)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	1	NC_006583.4 (59381980..59393371)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	1	NC_049222.1 (59137737..59149128)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	1	NC_049261.1 (58664392..58675778)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	1	NC_049742.1 (58505736..58517122)

Chromosome 1 - NC_051805.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLB mRNA was reduced 16-fold, and PLB protein was reduced 5-fold.
Title: Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines.
PLB decreases Ca(2+) binding to SERCA2a by stabilizing a unique E2.ATP state that is unable to bind thapsigargin or vanadate.
Title: Superinhibitory phospholamban mutants compete with Ca2+ for binding to SERCA2a by stabilizing a unique nucleotide-dependent conformational state.
Ca2+ binding to site I of the cardiac Ca2+ pump is sufficient to dissociate phospholamban
Title: Ca2+ binding to site I of the cardiac Ca2+ pump is sufficient to dissociate phospholamban.
Activation of cardiac muscle sarcoplasmic reticulum calcium-transporting ATPase (SERCA2a) dephosphorylation by nitroxyl (HNO) is PLN-dependent; PLN thiols are targets for HNO.
Title: Phospholamban thiols play a central role in activation of the cardiac muscle sarcoplasmic reticulum calcium pump by nitroxyl.
Phospholamban (PLB) oligomerization, quaternary structure, and sarco(endo)plasmic reticulum calcium ATPase (SERCA) binding were quantified by fluorescence resonance energy transfer (FRET) in an intact cellular environment.
Title: Phospholamban oligomerization, quaternary structure, and sarco(endo)plasmic reticulum calcium ATPase binding measured by fluorescence resonance energy transfer in living cells.
phospholamban leucine 31 has roles in structural and functional interactions with SERCA2a
Title: Role of leucine 31 of phospholamban in structural and functional interactions with the Ca2+ pump of cardiac sarcoplasmic reticulum.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATPase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of ATPase-coupled calcium transmembrane transporter activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of calcium ion import into sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of heart rate	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cardiac phospholamban

Names: PLB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.