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CG14694 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41307, updated on 4-Apr-2024

Summary

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Official Symbol
CG14694provided by FlyBase
Primary source
FLYBASE:FBgn0037845
Locus tag
Dmel_CG14694
See related
AllianceGenome:FB:FBgn0037845
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG14694
Summary
Predicted to enable thiamine transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including biotin-responsive basal ganglia disease; cleft lip; dextro-looped transposition of the great arteries; megaloblastic anemia; and thiamine-responsive megaloblastic anemia syndrome. Orthologous to human SLC19A1 (solute carrier family 19 member 1); SLC19A2 (solute carrier family 19 member 2); and SLC19A3 (solute carrier family 19 member 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
86C7-86C7; 3-50 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10858202..10859813, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6683924..6685535, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Selenoprotein R

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New comparative genomics approach reveals a conserved health span signature across species. Antosh M, et al. Aging (Albany NY), 2011 Jun. PMID 21775776, Free PMC Article
  2. A phylogenetic analysis between humans and D. melanogaster: A repertoire of solute carriers in humans and flies. Ceder MM, et al. Gene, 2022 Jan 30. PMID 34673204
  3. Function-informed transcriptome analysis of Drosophila renal tubule. Wang J, et al. Genome Biol, 2004. PMID 15345053, Free PMC Article
  4. Microbiota-induced changes in drosophila melanogaster host gene expression and gut morphology. Broderick NA, et al. mBio, 2014 May 27. PMID 24865556, Free PMC Article
  5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables thiamine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables vitamin transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vitamin transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG14694-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10858202..10859813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141771.3 → NP_650028.1  uncharacterized protein Dmel_CG14694 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650028.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VGV6
    Related
    FBpp0081774
    Conserved Domains (1) summary
    pfam01770
    Location:2 → 411
    Folate_carrier; Reduced folate carrier
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VGV6 Q9VGV6

Gene LinkOut

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