phu phurba tashi [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: phuprovided by FlyBase
Official Full Name: phurba tashiprovided by FlyBase
Primary source: FLYBASE:FBgn0043791
Locus tag: Dmel_CG8147
See related: AllianceGenome:FB:FBgn0043791
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 154821_at; Alp3; BEST:LD38109; CG8147; Dmel\CG8147
Summary: Predicted to enable alkaline phosphatase activity. Involved in response to hypoxia and response to nicotine. Predicted to be located in cell surface. Is expressed in several structures, including blastoderm embryo; ectoderm anlage; embryonic/larval circulatory system; extended germ band embryo; and germ layer. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and inflammatory bowel disease. Orthologous to several human genes including ALPL (alkaline phosphatase, biomineralization associated); ALPG (alkaline phosphatase, germ cell); and ALPI (alkaline phosphatase, intestinal). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (9494801..9496723)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (5320523..5322445)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables alkaline phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkaline phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info

NP_649897.4

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The following sections contain reference sequences that belong to a specific genome build. Explain