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MAGEA10 MAGE family member A10 [ Homo sapiens (human) ]

Gene ID: 4109, updated on 5-Mar-2024

Summary

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Official Symbol
MAGEA10provided by HGNC
Official Full Name
MAGE family member A10provided by HGNC
Primary source
HGNC:HGNC:6797
See related
Ensembl:ENSG00000124260 MIM:300343; AllianceGenome:HGNC:6797
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT1.10; MAGE10
Summary
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.[provided by RefSeq, Oct 2011]
Expression
Biased expression in placenta (RPKM 4.9) and testis (RPKM 1.2) See more
Orthologs
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Genomic context

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Location:
Xq28
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (152133310..152138577, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (150399374..150404642, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (151301782..151307049, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene 60 Neighboring gene uncharacterized LOC105373369 Neighboring gene MAGEA10-MAGEA5 readthrough Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:151297273-151298472 Neighboring gene MAGE family member A5, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4801 Neighboring gene Sharpr-MPRA regulatory region 4725 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha3 Neighboring gene RNA, U6 small nuclear 764, pseudogene Neighboring gene microRNA 105-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MAGEA10 expression is a predictive marker of early hepatic recurrence after curative gastrectomy for gastric and gastroesophageal junction cancer. Fujiya K, et al. Gastric Cancer, 2021 Mar. PMID 32965606
  2. MAGEA10 gene expression in non-small cell lung cancer and A549 cells, and the affinity of epitopes with the complex of HLA-A(∗)0201 alleles. Wang L, et al. Cell Immunol, 2015 Sep. PMID 26058806
  3. High expression of MAGE-A10 cancer-testis antigen in triple-negative breast cancer. Badovinac Črnjević T, et al. Med Oncol, 2012 Sep. PMID 22116775
  4. MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies. Schultz-Thater E, et al. Int J Cancer, 2011 Sep 1. PMID 21710496
  5. The use of filamentous bacteriophage fd to deliver MAGE-A10 or MAGE-A3 HLA-A2-restricted peptides and to induce strong antitumor CTL responses. Sartorius R, et al. J Immunol, 2008 Mar 15. PMID 18322177

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of MAGE A1 to MAGE A10 in the Forceps Biopsy and Bronchoalveolar Lavage Specimens from Patients with the Central Lung Tumor.
    Title: Expression of MAGE A1 to MAGE A10 in the Forceps Biopsy and Bronchoalveolar Lavage Specimens from Patients with the Central Lung Tumor.
  2. How the Intrinsically Disordered N-Terminus of Cancer/Testis Antigen MAGEA10 Is Responsible for Its Expression, Nuclear Localisation and Aberrant Migration.
    Title: How the Intrinsically Disordered N-Terminus of Cancer/Testis Antigen MAGEA10 Is Responsible for Its Expression, Nuclear Localisation and Aberrant Migration.
  3. MAGEA10 expression is a predictive marker of early hepatic recurrence after curative gastrectomy for gastric and gastroesophageal junction cancer.
    Title: MAGEA10 expression is a predictive marker of early hepatic recurrence after curative gastrectomy for gastric and gastroesophageal junction cancer.
  4. CTAs (MAGE-A4, NY-ESO-1, MAGE-A10) were more likely expressed in patients with squamous cell carcinoma of the lung and when CTAs combined with CD133, they can be better prognostic factors.
    Title: Predictive and prognostic effect of CD133 and cancer-testis antigens in stage Ib-IIIA non-small cell lung cancer.
  5. By using Molecular-Docking, 3 MAGEA10 peptides were found binding to the groove position of HLA-A( *)0210 same as MAGEA4 peptide co-crystallized with HLA-A( *)0210, which indicates they could be promising for HLA-A( *)0201 presentation in immunotherapy.
    Title: MAGEA10 gene expression in non-small cell lung cancer and A549 cells, and the affinity of epitopes with the complex of HLA-A(∗)0201 alleles.
  6. We clearly showed that MAGE-A10 is frequently expressed in the group of triple-negative breast cancer patients
    Title: High expression of MAGE-A10 cancer-testis antigen in triple-negative breast cancer.
  7. High MAGE-A10 is associated with lung, skin and urothelial malignancies.
    Title: MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies.
  8. This is the first report of these MAGE-A10 alternative splice sequences, and characterization of MAGE-A expression
    Title: Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC10599

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
melanoma-associated antigen 10
Names
MAGE-10 antigen
cancer/testis antigen 1.10
cancer/testis antigen family 1, member 10
melanoma antigen family A, 10
melanoma antigen family A10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011543.3 → NP_001011543.3  melanoma-associated antigen 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC116666
    Consensus CDS
    CCDS14705.1
    UniProtKB/Swiss-Prot
    P43363
    UniProtKB/TrEMBL
    B2RAE8
    Related
    ENSP00000244096.3, ENST00000244096.7
    Conserved Domains (2) summary
    pfam01454
    Location:141 → 306
    MAGE; MAGE family
    pfam12440
    Location:6 → 116
    MAGE_N; Melanoma associated antigen family N terminal

  2. NM_001251828.2 → NP_001238757.2  melanoma-associated antigen 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC116666
    Consensus CDS
    CCDS14705.1
    UniProtKB/Swiss-Prot
    P43363
    UniProtKB/TrEMBL
    B2RAE8
    Conserved Domains (2) summary
    pfam01454
    Location:141 → 306
    MAGE; MAGE family
    pfam12440
    Location:6 → 116
    MAGE_N; Melanoma associated antigen family N terminal

  3. NM_021048.5 → NP_066386.3  melanoma-associated antigen 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC116666
    Consensus CDS
    CCDS14705.1
    UniProtKB/Swiss-Prot
    P43363
    UniProtKB/TrEMBL
    B2RAE8
    Related
    ENSP00000359347.4, ENST00000370323.9
    Conserved Domains (2) summary
    pfam01454
    Location:141 → 306
    MAGE; MAGE family
    pfam12440
    Location:6 → 116
    MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    152133310..152138577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    150399374..150404642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43363.2 GenPept UniProtKB/Swiss-Prot:P43363

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