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Zfp874b zinc finger protein 874b [ Mus musculus (house mouse) ]

Gene ID: 408067, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp874bprovided by MGI
Official Full Name
zinc finger protein 874bprovided by MGI
Primary source
MGI:MGI:3040702
See related
Ensembl:ENSMUSG00000059839 AllianceGenome:MGI:3040702
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rslcan16; 9630025I21Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF429 (zinc finger protein 429). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 1.6), bladder adult (RPKM 1.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
13 B3; 13 34.54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67619632..67634360, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67471513..67486241, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 874a Neighboring gene STARR-seq mESC enhancer starr_34904 Neighboring gene predicted gene 7928 Neighboring gene STARR-positive B cell enhancer ABC_E5405 Neighboring gene zinc finger protein 58 Neighboring gene STARR-positive B cell enhancer ABC_E8532 Neighboring gene zinc finger protein 458 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2. Krebs CJ, et al. Genomics, 2005 Jun. PMID 15885501
  2. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Krebs CJ, et al. Genes Dev, 2003 Nov 1. PMID 14563677, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 874b
Names
regulator of sex-limitation candidate 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076791.2 → NP_001070259.1  zinc finger protein 874b

    See identical proteins and their annotated locations for NP_001070259.1

    Status: VALIDATED

    Source sequence(s)
    AC154510, BK001633, BY228006, CF727126
    Consensus CDS
    CCDS49302.1
    UniProtKB/TrEMBL
    Q7M6X2
    Related
    ENSMUSP00000019572.7, ENSMUST00000019572.9
    Conserved Domains (5) summary
    smart00349
    Location:5 → 59
    KRAB; krueppel associated box
    COG5048
    Location:143 → 423
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:166 → 186
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5 → 44
    KRAB; KRAB box
    pfam13465
    Location:178 → 203
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    67619632..67634360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244536.2 → XP_011242838.1  zinc finger protein 874b isoform X2

    See identical proteins and their annotated locations for XP_011242838.1

    Conserved Domains (3) summary
    smart00349
    Location:2 → 56
    KRAB; krueppel associated box
    COG5048
    Location:140 → 420
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:163 → 183
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_011244535.2 → XP_011242837.1  zinc finger protein 874b isoform X2

    See identical proteins and their annotated locations for XP_011242837.1

    Conserved Domains (3) summary
    smart00349
    Location:2 → 56
    KRAB; krueppel associated box
    COG5048
    Location:140 → 420
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:163 → 183
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_030247316.1 → XP_030103176.1  zinc finger protein 874b isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:48 → 328
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:71 → 91
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_030247315.1 → XP_030103175.1  zinc finger protein 874b isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:48 → 328
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:71 → 91
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_030247318.1 → XP_030103178.1  zinc finger protein 874b isoform X4

    UniProtKB/TrEMBL
    A0A286YDP7
    Conserved Domains (1) summary
    smart00349
    Location:9 → 63
    KRAB; krueppel associated box

  6. XM_006517283.3 → XP_006517346.1  zinc finger protein 874b isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:9 → 63
    KRAB; krueppel associated box
    COG5048
    Location:147 → 427
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:170 → 190
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_036158084.1 → XP_036013977.1  zinc finger protein 874b isoform X2

    Conserved Domains (3) summary
    smart00349
    Location:2 → 56
    KRAB; krueppel associated box
    COG5048
    Location:140 → 420
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:163 → 183
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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