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Ndufa4l2 Ndufa4, mitochondrial complex associated like 2 [ Mus musculus (house mouse) ]

Gene ID: 407790, updated on 5-Mar-2024

Summary

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Official Symbol
Ndufa4l2provided by MGI
Official Full Name
Ndufa4, mitochondrial complex associated like 2provided by MGI
Primary source
MGI:MGI:3039567
See related
Ensembl:ENSMUSG00000040280 AllianceGenome:MGI:3039567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be part of mitochondrial respiratory chain complex IV. Is expressed in several structures, including brain; heart; integumental system; nose; and reproductive system. Orthologous to human NDUFA4L2 (NDUFA4 mitochondrial complex associated like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 37.3), adrenal adult (RPKM 32.7) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Ndufa4l2 in Genome Data Viewer
Location:
10 D3; 10 74.51 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127345143..127353023)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127509274..127517154)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene R3H domain containing 2 Neighboring gene predicted gene, 23819 Neighboring gene STARR-positive B cell enhancer mm9_chr10:126945421-126945721 Neighboring gene STARR-positive B cell enhancer ABC_E10656 Neighboring gene STARR-positive B cell enhancer ABC_E2342 Neighboring gene STARR-positive B cell enhancer ABC_E1132 Neighboring gene SH3 and cysteine rich domain 3 Neighboring gene serine hydroxymethyltransferase 2 (mitochondrial) Neighboring gene neurexophilin 4 Neighboring gene low density lipoprotein receptor-related protein 1 Neighboring gene STARR-seq mESC enhancer starr_28231 Neighboring gene predicted gene 16217

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force. Liu Z, et al. FASEB J, 2021 Dec. PMID 34724256
  2. Unique expression of the atypical mitochondrial subunit NDUFA4L2 in cerebral pericytes fine tunes HIF activity in response to hypoxia. Mesa-Ciller C, et al. J Cereb Blood Flow Metab, 2023 Jan. PMID 35929074, Free PMC Article
  3. Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy. Xu WN, et al. Exp Mol Med, 2019 Nov 18. PMID 31740659, Free PMC Article
  4. Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity. Tello D, et al. Cell Metab, 2011 Dec 7. PMID 22100406
  5. Acute O(2) sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors. Moreno-Domínguez A, et al. Sci Signal, 2020 Jan 21. PMID 31848220

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unique expression of the atypical mitochondrial subunit NDUFA4L2 in cerebral pericytes fine tunes HIF activity in response to hypoxia.
    Title: Unique expression of the atypical mitochondrial subunit NDUFA4L2 in cerebral pericytes fine tunes HIF activity in response to hypoxia.
  2. Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force.
    Title: Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force.
  3. The results demonstrated that the upregulation of NDUFA4L2 ameliorated the apoptosis of NP cells by repressing excessive mitophagy, which ultimately alleviated IVDD. These findings show for the first time that NDUFA4L2 and mitophagy may be potential therapeutic targets for IVDD.
    Title: Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy.
  4. Induction of the mitochondrial NDUFA4L2 protein by HIF-1alpha decreases oxygen consumption by inhibiting Complex I activity.
    Title: Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117746

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of mitochondrial respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2
Names
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098789.1 → NP_001092259.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2

    See identical proteins and their annotated locations for NP_001092259.1

    Status: VALIDATED

    Source sequence(s)
    BC099496, BY336656
    Consensus CDS
    CCDS36080.1
    UniProtKB/Swiss-Prot
    Q4FZG9
    Related
    ENSMUSP00000042185.10, ENSMUST00000035735.11
    Conserved Domains (1) summary
    pfam06522
    Location:16 → 84
    B12D; NADH-ubiquinone reductase complex 1 MLRQ subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127345143..127353023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245154.1 → XP_030101014.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X2

    Conserved Domains (1) summary
    pfam06522
    Location:1 → 62
    B12D; NADH-ubiquinone reductase complex 1 MLRQ subunit

  2. XM_006513834.3 → XP_006513897.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X1

    Conserved Domains (1) summary
    pfam06522
    Location:17 → 81
    B12D; NADH-ubiquinone reductase complex 1 MLRQ subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4FZG9.1 GenPept UniProtKB/Swiss-Prot:Q4FZG9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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