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Taf9b TATA-box binding protein associated factor 9B [ Mus musculus (house mouse) ]

Gene ID: 407786, updated on 5-Mar-2024

Summary

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Official Symbol
Taf9bprovided by MGI
Official Full Name
TATA-box binding protein associated factor 9Bprovided by MGI
Primary source
MGI:MGI:3039562
See related
Ensembl:ENSMUSG00000047242 AllianceGenome:MGI:3039562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Taf9l
Summary
Predicted to enable protein heterodimerization activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of cell growth; and protein stabilization. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIID complex and transcription factor TFTC complex. Is expressed in tail. Orthologous to human TAF9B (TATA-box binding protein associated factor 9b). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 7.0), cortex adult (RPKM 6.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X D; X 47.36 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (105250480..105264764, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (106206874..106221158, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene TM2 domain containing 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1985 Neighboring gene phosphoglycerate kinase 1 Neighboring gene fibronectin type III domain containing 3C2 Neighboring gene fibronectin type III domain containing 3C2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Core promoter factor TAF9B regulates neuronal gene expression. Herrera FJ, et al. Elife, 2014 Jul 8. PMID 25006164, Free PMC Article
  2. Targeted deletion of CASK-interacting nucleosome assembly protein causes higher locomotor and exploratory activities. Chung WC, et al. Neurosignals, 2011. PMID 21576927
  3. Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation. He Y, et al. Aging Cell, 2021 Jul. PMID 34174788, Free PMC Article
  4. The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Bardot P, et al. Development, 2017 Oct 15. PMID 28893950, Free PMC Article
  5. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TAF9B also regulates neuronal gene transcription in vivo.
    Title: Core promoter factor TAF9B regulates neuronal gene expression.
  2. These observations suggest that although CINAP deletion in mice does not influence learning and memory behaviors, CINAP is required for restriction of locomotor and exploratory activities.
    Title: Targeted deletion of CASK-interacting nucleosome assembly protein causes higher locomotor and exploratory activities.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFTC complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription initiation factor TFIID subunit 9B
Names
TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor
transcription-associated factor TAFII31L
NP_001001176.2
NP_001161460.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001176.2 → NP_001001176.2  transcription initiation factor TFIID subunit 9B isoform 2

    See identical proteins and their annotated locations for NP_001001176.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    BC051635, BC066223, CA559941
    Consensus CDS
    CCDS30340.1
    UniProtKB/Swiss-Prot
    A2AP80, Q3UXZ3, Q3V2M4, Q6NZA9, Q80WW6
    Related
    ENSMUSP00000059751.9, ENSMUST00000055497.15
    Conserved Domains (1) summary
    cd07979
    Location:13 → 129
    TAF9; TATA Binding Protein (TBP) Associated Factor 9 (TAF9) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

  2. NM_001167988.1 → NP_001161460.1  transcription initiation factor TFIID subunit 9B isoform 1

    See identical proteins and their annotated locations for NP_001161460.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK131710, BC066223
    Consensus CDS
    CCDS53170.1
    UniProtKB/TrEMBL
    A2AP82
    Related
    ENSMUSP00000109123.3, ENSMUST00000113495.9
    Conserved Domains (1) summary
    cd07979
    Location:57 → 173
    TAF9; TATA Binding Protein (TBP) Associated Factor 9 (TAF9) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    105250480..105264764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NZA9.2 GenPept UniProtKB/Swiss-Prot:Q6NZA9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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