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MIR221 microRNA 221 [ Homo sapiens (human) ]

Gene ID: 407006, updated on 10-Dec-2024

Summary

Official Symbol
MIR221provided by HGNC
Official Full Name
microRNA 221provided by HGNC
Primary source
HGNC:HGNC:31601
See related
Ensembl:ENSG00000207870 MIM:300568; miRBase:MI0000298; AllianceGenome:HGNC:31601
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN221; mir-221; miRNA221
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR221 in Genome Data Viewer
Location:
Xp11.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (45746157..45746266, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (45155612..45155721, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (45605585..45605694, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene keratin 8 pseudogene 14 Neighboring gene Sharpr-MPRA regulatory region 11747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29569 Neighboring gene Sharpr-MPRA regulatory region 14703 Neighboring gene MFF pseudogene 3 Neighboring gene miR222/221 cluster host gene Neighboring gene microRNA 222 Neighboring gene NANOG hESC enhancer GRCh37_chrX:45645628-45646174 Neighboring gene NANOG hESC enhancer GRCh37_chrX:45661291-45661869 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:45662536-45663735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20789 Neighboring gene long intergenic non-protein coding RNA 2595

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Other Names

  • hsa-mir-221

Gene Ontology Provided by GOA

Items 1 - 25 of 41
Process Evidence Code Pubs
acts_upstream_of inflammatory response PubMed 
involved_in miRNA-mediated gene silencing by inhibition of translation PubMed 
involved_in miRNA-mediated gene silencing by inhibition of translation PubMed 
involved_in miRNA-mediated post-transcriptional gene silencing PubMed 
involved_in miRNA-mediated post-transcriptional gene silencing PubMed 
involved_in miRNA-mediated post-transcriptional gene silencing PubMed 
involved_in negative regulation by host of viral genome replication  
involved_in negative regulation of ERK1 and ERK2 cascade PubMed 
involved_in negative regulation of TRAIL-activated apoptotic signaling pathway PubMed 
involved_in negative regulation of apoptotic process PubMed 
involved_in negative regulation of apoptotic process PubMed 
involved_in negative regulation of cell adhesion molecule production PubMed 
involved_in negative regulation of cell migration involved in sprouting angiogenesis PubMed 
involved_in negative regulation of cell population proliferation PubMed 
involved_in negative regulation of cytokine production involved in inflammatory response  
involved_in negative regulation of double-strand break repair PubMed 
involved_in negative regulation of hematopoietic stem cell proliferation PubMed 
involved_in negative regulation of heterotypic cell-cell adhesion PubMed 
involved_in negative regulation of inflammatory response PubMed 
involved_in negative regulation of interleukin-21 production PubMed 
involved_in negative regulation of leukocyte adhesion to vascular endothelial cell PubMed 
involved_in negative regulation of necroptotic process PubMed 
involved_in negative regulation of sprouting angiogenesis PubMed 
involved_in negative regulation of vascular associated smooth muscle cell differentiation PubMed 
involved_in platelet-derived growth factor receptor signaling pathway PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle PubMed 
involved_in positive regulation of Schwann cell migration  
involved_in positive regulation of Schwann cell proliferation involved in axon regeneration  
involved_in positive regulation of apoptotic process PubMed 
involved_in positive regulation of axon regeneration  
involved_in positive regulation of blood vessel endothelial cell migration PubMed 
involved_in positive regulation of epithelial cell migration PubMed 
involved_in positive regulation of epithelial to mesenchymal transition PubMed 
involved_in positive regulation of erythrocyte differentiation PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT PubMed 
involved_in positive regulation of vascular associated smooth muscle cell dedifferentiation PubMed 
involved_in positive regulation of vascular associated smooth muscle cell migration PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation  
involved_in positive regulation of wound healing, spreading of epidermal cells PubMed 
involved_in response to glucose PubMed 
Items 1 - 25 of 41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029635.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC234772
    Related
    ENST00000385135.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    45746157..45746266 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    45155612..45155721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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