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CG11999 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40637, updated on 29-Dec-2023

Summary

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Official Symbol
CG11999provided by FlyBase
Primary source
FLYBASE:FBgn0037312
Locus tag
Dmel_CG11999
See related
AllianceGenome:FB:FBgn0037312
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:LD29996; CG-11999; Dmel\CG11999
Summary
Predicted to enable misfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Located in endomembrane system. Is expressed in adult head and adult heart. Orthologous to several human genes including SDF2L1 (stromal cell derived factor 2 like 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
82F10-82F10; 3-47.5 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5353717..5354747, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1179439..1180469, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mustard Neighboring gene uncharacterized protein Neighboring gene Tim17b1 Neighboring gene Proteasome beta7 subunit Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein-DNA interaction mapping using genomic tiling path microarrays in Drosophila. Sun LV, et al. Proc Natl Acad Sci U S A, 2003 Aug 5. PMID 12876199, Free PMC Article
  2. Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival. Creagh EM, et al. PLoS One, 2009. PMID 19330035, Free PMC Article
  3. Widespread Rewiring of Genetic Networks upon Cancer Signaling Pathway Activation. Billmann M, et al. Cell Syst, 2018 Jan 24. PMID 29199019, Free PMC Article
  4. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article
  5. The Hippo signaling pathway interactome. Kwon Y, et al. Science, 2013 Nov 8. PMID 24114784, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables misfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein folding chaperone complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG11999-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5353717..5354747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141270.1 → NP_649527.1  uncharacterized protein Dmel_CG11999 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649527.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNA3
    Related
    FBpp0078450, FBtr0078807
    Conserved Domains (1) summary
    smart00472
    Location:86 → 138
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VNA3 Q9VNA3

Gene LinkOut

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