U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cchcr1 coiled-coil alpha-helical rod protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 406196, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Cchcr1provided by RGD
Official Full Name
coiled-coil alpha-helical rod protein 1provided by RGD
Primary source
RGD:1302992
See related
Ensembl:ENSRNOG00000050233 AllianceGenome:RGD:1302992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hcr; C6orf18
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in protein export from nucleus. Predicted to be located in cytosol. Predicted to be active in centriole. Orthologous to human CCHCR1 (coiled-coil alpha-helical rod protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 407.9), Thymus (RPKM 90.7) and 5 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
20p12
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3210383..3223187, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3205675..3218437, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3730968..3745721, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L22, pseudogene 1 Neighboring gene psoriasis susceptibility 1 candidate 2 Neighboring gene transcription factor 19 Neighboring gene POU class 5 homeobox 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base. Wang WJ, et al. Nat Cell Biol, 2013 Jun. PMID 23644468, Free PMC Article
  2. RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product. Corbi N, et al. J Cell Sci, 2005 Sep 15. PMID 16141233
  3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
coiled-coil alpha-helical rod protein 1
Names
HCR (a-helix coiled-coil rod homolog)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002822.2 → NP_001002822.2  coiled-coil alpha-helical rod protein 1

    Status: VALIDATED

    Source sequence(s)
    BC105619, CV126837
    UniProtKB/TrEMBL
    A0A0G2K6P2, A6KTB3
    Related
    ENSRNOP00000073888.2, ENSRNOT00000084918.2
    Conserved Domains (2) summary
    pfam07111
    Location:110 → 853
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl19219
    Location:305 → 384
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    3210383..3223187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279375.1 → XP_063135445.1  coiled-coil alpha-helical rod protein 1 isoform X10

  2. XM_063279370.1 → XP_063135440.1  coiled-coil alpha-helical rod protein 1 isoform X8

  3. XM_039098944.1 → XP_038954872.1  coiled-coil alpha-helical rod protein 1 isoform X7

    UniProtKB/TrEMBL
    Q0D2L7, Q6MG25
    Conserved Domains (1) summary
    pfam07111
    Location:27 → 770
    HCR; Alpha helical coiled-coil rod protein (HCR)

  4. XM_039098943.2 → XP_038954871.1  coiled-coil alpha-helical rod protein 1 isoform X7

    UniProtKB/TrEMBL
    Q0D2L7, Q6MG25
    Conserved Domains (1) summary
    pfam07111
    Location:27 → 770
    HCR; Alpha helical coiled-coil rod protein (HCR)

  5. XM_039098941.2 → XP_038954869.1  coiled-coil alpha-helical rod protein 1 isoform X7

    UniProtKB/TrEMBL
    Q0D2L7, Q6MG25
    Conserved Domains (1) summary
    pfam07111
    Location:27 → 770
    HCR; Alpha helical coiled-coil rod protein (HCR)

  6. XM_039098946.2 → XP_038954874.1  coiled-coil alpha-helical rod protein 1 isoform X7

    UniProtKB/TrEMBL
    Q0D2L7, Q6MG25
    Conserved Domains (1) summary
    pfam07111
    Location:27 → 770
    HCR; Alpha helical coiled-coil rod protein (HCR)

  7. XM_063279373.1 → XP_063135443.1  coiled-coil alpha-helical rod protein 1 isoform X9

    UniProtKB/TrEMBL
    A6KTB4

  8. XM_039098942.2 → XP_038954870.1  coiled-coil alpha-helical rod protein 1 isoform X7

    UniProtKB/TrEMBL
    Q0D2L7, Q6MG25
    Conserved Domains (1) summary
    pfam07111
    Location:27 → 770
    HCR; Alpha helical coiled-coil rod protein (HCR)

  9. XM_063279372.1 → XP_063135442.1  coiled-coil alpha-helical rod protein 1 isoform X9

    UniProtKB/TrEMBL
    A6KTB4

  10. XM_063279366.1 → XP_063135436.1  coiled-coil alpha-helical rod protein 1 isoform X4

  11. XM_039098938.2 → XP_038954866.1  coiled-coil alpha-helical rod protein 1 isoform X3

    UniProtKB/TrEMBL
    A6KTB3
    Conserved Domains (1) summary
    pfam07111
    Location:110 → 833
    HCR; Alpha helical coiled-coil rod protein (HCR)

  12. XM_039098939.2 → XP_038954867.1  coiled-coil alpha-helical rod protein 1 isoform X5

    UniProtKB/TrEMBL
    A6KTB3
    Conserved Domains (1) summary
    pfam07111
    Location:110 → 803
    HCR; Alpha helical coiled-coil rod protein (HCR)

  13. XM_063279367.1 → XP_063135437.1  coiled-coil alpha-helical rod protein 1 isoform X6

  14. XM_039098937.2 → XP_038954865.1  coiled-coil alpha-helical rod protein 1 isoform X2

    UniProtKB/TrEMBL
    A6KTB3
    Conserved Domains (1) summary
    pfam07111
    Location:110 → 839
    HCR; Alpha helical coiled-coil rod protein (HCR)

  15. XM_039098936.2 → XP_038954864.1  coiled-coil alpha-helical rod protein 1 isoform X1

    UniProtKB/TrEMBL
    A6KTB3
    Conserved Domains (1) summary
    pfam07111
    Location:110 → 840
    HCR; Alpha helical coiled-coil rod protein (HCR)

  16. XM_063279371.1 → XP_063135441.1  coiled-coil alpha-helical rod protein 1 isoform X9

    UniProtKB/TrEMBL
    A6KTB4

  17. XM_063279368.1 → XP_063135438.1  coiled-coil alpha-helical rod protein 1 isoform X7

    UniProtKB/TrEMBL
    Q0D2L7

  18. XM_063279369.1 → XP_063135439.1  coiled-coil alpha-helical rod protein 1 isoform X7

    UniProtKB/TrEMBL
    Q0D2L7

  19. XM_063279374.1 → XP_063135444.1  coiled-coil alpha-helical rod protein 1 isoform X10

  20. XM_063279376.1 → XP_063135446.1  coiled-coil alpha-helical rod protein 1 isoform X11

  21. XM_039098948.2 → XP_038954876.1  coiled-coil alpha-helical rod protein 1 isoform X12

    Conserved Domains (1) summary
    pfam07111
    Location:110 → 630
    HCR; Alpha helical coiled-coil rod protein (HCR)

RNA

  1. XR_005497314.2 RNA Sequence

  2. XR_005497313.2 RNA Sequence

  3. XR_005497315.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous