ARNT aryl hydrocarbon receptor nuclear translocator [Homo sapiens (human)] - Gene

Summary

Official Symbol: ARNTprovided by HGNC
Official Full Name: aryl hydrocarbon receptor nuclear translocatorprovided by HGNC
Primary source: HGNC:HGNC:700
See related: Ensembl:ENSG00000143437 MIM:126110; AllianceGenome:HGNC:700
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARNT1; HIF1B; TANGO; bHLHe2; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta
Summary: This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Expression: Ubiquitous expression in ovary (RPKM 16.9), placenta (RPKM 14.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q21.3

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (150809713..150876599, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (149933391..150000287, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (150782189..150849075, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.
Title: Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.
Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies.
Title: Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies.
Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1beta.
Title: Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β.
AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity.
Title: AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity.
The Contribution of Genetic Variation and Aberrant Methylation of Aryl Hydrocarbon Receptor Signaling Pathway Genes to Rheumatoid Arthritis.
Title: The Contribution of Genetic Variation and Aberrant Methylation of Aryl Hydrocarbon Receptor Signaling Pathway Genes to Rheumatoid Arthritis.
Hypoxia-inducible factor-1beta is essential for upregulation of the hypoxia-induced FLT1 gene in placental trophoblasts.
Title: Hypoxia-inducible factor-1β is essential for upregulation of the hypoxia-induced FLT1 gene in placental trophoblasts.
GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion.
Title: GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion.
The role of DNA-binding and ARNT dimerization on the nucleo-cytoplasmic translocation of the aryl hydrocarbon receptor.
Title: The role of DNA-binding and ARNT dimerization on the nucleo-cytoplasmic translocation of the aryl hydrocarbon receptor.
Detrimental effects of hypoxia on glomerular podocytes.
Title: Detrimental effects of hypoxia on glomerular podocytes.
Transethnic associations among immune-mediated diseases and single-nucleotide polymorphisms of the aryl hydrocarbon response gene ARNT and the PTPN22 immune regulatory gene.
Title: Transethnic associations among immune-mediated diseases and single-nucleotide polymorphisms of the aryl hydrocarbon response gene ARNT and the PTPN22 immune regulatory gene.

Submit: New GeneRIF Correction See all GeneRIFs (113)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
matrix	gag	HIV-1 MA downregulates ARNT gene expression in HepG2 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S3284 (e-PCR)
- UniSTS:19515

RH93022 (e-PCR)
- UniSTS:88147

ARNT_2212 (e-PCR)
- UniSTS:280450

D1S3204 (e-PCR)
- UniSTS:73864

SGC30626 (e-PCR)
- UniSTS:10143

G15891 (e-PCR)
- UniSTS:63653

RH11989 (e-PCR)
- UniSTS:38823

RH118541 (e-PCR)
- UniSTS:137938

WI-16757 (e-PCR)
- UniSTS:77807

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables aryl hydrocarbon receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IDA Inferred from Direct Assay more info
involved_in embryonic placenta development	IEA Inferred from Electronic Annotation more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IC Inferred by Curator more info	PubMed
involved_in positive regulation of erythrocyte differentiation	IC Inferred by Curator more info
involved_in positive regulation of hormone biosynthetic process	IDA Inferred from Direct Assay more info
involved_in positive regulation of protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vascular endothelial growth factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	IC Inferred by Curator more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of aryl hydrocarbon receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of nuclear aryl hydrocarbon receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aryl hydrocarbon receptor nuclear translocator

Names: class E basic helix-loop-helix protein 2; dioxin receptor, nuclear translocator; hypoxia inducible factor 1 subunit beta; hypoxia-inducible factor 1, beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_028248.1 RefSeqGene

Range

5170..72056

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001197325.2 → NP_001184254.1 aryl hydrocarbon receptor nuclear translocator isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AK291705, AL355860, BU730937

UniProtKB/TrEMBL

A8K6P0

Conserved Domains (5) summary

smart00091
Location:151 → 215

PAS; PAS domain

cd00130
Location:347 → 443

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:76 → 128

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:148 → 254

PAS; PAS fold

pfam14598
Location:347 → 447

PAS_11; PAS domain
NM_001286035.2 → NP_001272964.1 aryl hydrocarbon receptor nuclear translocator isoform 5

See identical proteins and their annotated locations for NP_001272964.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) contains an alternate exon in the 5' region, initiates translation at a downstream in-frame start codon, and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.

Source sequence(s)

AK223459, AK293027, AL355860, AL834279, BU730937

Consensus CDS

CCDS65641.1

UniProtKB/TrEMBL

B0AZM1

Related

ENSP00000423851.1, ENST00000515192.5

Conserved Domains (6) summary

smart00091
Location:157 → 221

PAS; PAS domain

cd00130
Location:348 → 444

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:82 → 134

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:154 → 260

PAS; PAS fold

pfam11593
Location:509 → 720

Med3; Mediator complex subunit 3 fungal

pfam14598
Location:348 → 448

PAS_11; PAS domain
NM_001286036.2 → NP_001272965.1 aryl hydrocarbon receptor nuclear translocator isoform 6

See identical proteins and their annotated locations for NP_001272965.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.

Source sequence(s)

AB209877, AK223459, AK293027, AL355860, BU730937

Consensus CDS

CCDS65642.1

UniProtKB/TrEMBL

B0AZM1

Related

ENSP00000346372.2, ENST00000354396.6

Conserved Domains (3) summary

cd18947
Location:86 → 150

bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins

pfam00989
Location:163 → 269

PAS; PAS fold

pfam14598
Location:362 → 462

PAS_11; PAS domain
NM_001350224.2 → NP_001337153.1 aryl hydrocarbon receptor nuclear translocator isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (7) contains an alternate exon in the 5' region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (7) has a shorter N-terminus than isoform 1.

Source sequence(s)

AK293027, AL355860, BC041121, BU730937

UniProtKB/TrEMBL

B0AZM1

Conserved Domains (4) summary

pfam00010
Location:82 → 134

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:154 → 260

PAS; PAS fold

pfam11593
Location:514 → 725

Med3; Mediator complex subunit 3 fungal

cl25986
Location:353 → 453

PAS_3; PAS fold
NM_001350225.2 → NP_001337154.1 aryl hydrocarbon receptor nuclear translocator isoform 8

Status: REVIEWED

Description

Transcript Variant: This variant (8) uses an alternate splice site in its 5' coding region, resulting in the use of an alternate start codon, compared to variant 1. The encoded isoform (8) has a slightly shorter, but distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK293027, AL355860, BC041121, BU730937

UniProtKB/TrEMBL

B4E3L5

Conserved Domains (4) summary

pfam00010
Location:90 → 142

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:162 → 268

PAS; PAS fold

pfam11593
Location:522 → 733

Med3; Mediator complex subunit 3 fungal

cl25986
Location:361 → 461

PAS_3; PAS fold
NM_001350226.2 → NP_001337155.1 aryl hydrocarbon receptor nuclear translocator isoform 9

Status: REVIEWED

Description

Transcript Variant: This variant (9) uses an alternate splice site in its 5' coding region, resulting in the use of an alternate start codon, compared to variant 1. The encoded isoform (8) has a slightly shorter, but distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK293027, AL355860, BC041121, BU730937

UniProtKB/TrEMBL

B4E3L5

Conserved Domains (4) summary

pfam00010
Location:89 → 141

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:161 → 267

PAS; PAS fold

pfam11593
Location:521 → 732

Med3; Mediator complex subunit 3 fungal

cl25986
Location:360 → 460

PAS_3; PAS fold
NM_001668.4 → NP_001659.1 aryl hydrocarbon receptor nuclear translocator isoform 1

See identical proteins and their annotated locations for NP_001659.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK293027, AL355860, BC041121, BU730937

Consensus CDS

CCDS970.1

UniProtKB/Swiss-Prot

B2R9H1, C4AMA1, F8WAP6, P27540, Q59ED4, Q5QP39, Q8NDC7

UniProtKB/TrEMBL

B0AZM1

Related

ENSP00000351407.5, ENST00000358595.10

Conserved Domains (6) summary

smart00091
Location:166 → 230

PAS; PAS domain

cd00130
Location:362 → 458

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:91 → 143

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:163 → 269

PAS; PAS fold

pfam11593
Location:523 → 734

Med3; Mediator complex subunit 3 fungal

pfam14598
Location:362 → 462

PAS_11; PAS domain
NM_178427.3 → NP_848514.1 aryl hydrocarbon receptor nuclear translocator isoform 3

See identical proteins and their annotated locations for NP_848514.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AK315812, AL355860, BU730937

Consensus CDS

CCDS971.1

UniProtKB/TrEMBL

A8K6P0, B0AZM1

Related

ENSP00000427571.1, ENST00000505755.5

Conserved Domains (6) summary

smart00091
Location:151 → 215

PAS; PAS domain

cd00130
Location:347 → 443

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:76 → 128

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:148 → 254

PAS; PAS fold

pfam11593
Location:508 → 719

Med3; Mediator complex subunit 3 fungal

pfam14598
Location:347 → 447

PAS_11; PAS domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

150809713..150876599 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047420740.1 → XP_047276696.1 aryl hydrocarbon receptor nuclear translocator isoform X29
XM_047420734.1 → XP_047276690.1 aryl hydrocarbon receptor nuclear translocator isoform X28
XM_047420716.1 → XP_047276672.1 aryl hydrocarbon receptor nuclear translocator isoform X20
XM_047420715.1 → XP_047276671.1 aryl hydrocarbon receptor nuclear translocator isoform X19
XM_047420727.1 → XP_047276683.1 aryl hydrocarbon receptor nuclear translocator isoform X27
XM_017001296.2 → XP_016856785.1 aryl hydrocarbon receptor nuclear translocator isoform X26

UniProtKB/TrEMBL

A8K6P0
XM_047420719.1 → XP_047276675.1 aryl hydrocarbon receptor nuclear translocator isoform X25
XM_017001295.2 → XP_016856784.1 aryl hydrocarbon receptor nuclear translocator isoform X24

UniProtKB/TrEMBL

A8K6P0, B0AZM1
XM_047420711.1 → XP_047276667.1 aryl hydrocarbon receptor nuclear translocator isoform X16
XM_005245153.2 → XP_005245210.1 aryl hydrocarbon receptor nuclear translocator isoform X15

UniProtKB/TrEMBL

B0AZM1

Conserved Domains (6) summary

smart00091
Location:166 → 230

PAS; PAS domain

cd00130
Location:357 → 453

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:91 → 143

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:163 → 269

PAS; PAS fold

pfam11593
Location:518 → 729

Med3; Mediator complex subunit 3 fungal

pfam14598
Location:357 → 457

PAS_11; PAS domain
XM_017001294.2 → XP_016856783.1 aryl hydrocarbon receptor nuclear translocator isoform X23

UniProtKB/TrEMBL

A8K6P0
XM_005245157.2 → XP_005245214.1 aryl hydrocarbon receptor nuclear translocator isoform X22

UniProtKB/TrEMBL

A8K6P0, B0AZM1

Conserved Domains (6) summary

smart00091
Location:166 → 230

PAS; PAS domain

cd00130
Location:362 → 458

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:91 → 143

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:163 → 269

PAS; PAS fold

pfam11593
Location:486 → 697

Med3; Mediator complex subunit 3 fungal

pfam14598
Location:362 → 462

PAS_11; PAS domain
XM_005245151.3 → XP_005245208.1 aryl hydrocarbon receptor nuclear translocator isoform X12

UniProtKB/TrEMBL

A8K6P0

Conserved Domains (5) summary

smart00091
Location:166 → 230

PAS; PAS domain

cd00130
Location:362 → 458

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:91 → 143

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:163 → 269

PAS; PAS fold

pfam14598
Location:362 → 462

PAS_11; PAS domain
XM_047420697.1 → XP_047276653.1 aryl hydrocarbon receptor nuclear translocator isoform X7
XM_047420694.1 → XP_047276650.1 aryl hydrocarbon receptor nuclear translocator isoform X6
XM_017001293.2 → XP_016856782.1 aryl hydrocarbon receptor nuclear translocator isoform X11

UniProtKB/TrEMBL

A8K6P0
XM_047420701.1 → XP_047276657.1 aryl hydrocarbon receptor nuclear translocator isoform X10
XM_017001291.2 → XP_016856780.1 aryl hydrocarbon receptor nuclear translocator isoform X5

UniProtKB/TrEMBL

A8K6P0
XM_017001290.3 → XP_016856779.1 aryl hydrocarbon receptor nuclear translocator isoform X4

UniProtKB/TrEMBL

A8K6P0, B0AZM1
XM_047420692.1 → XP_047276648.1 aryl hydrocarbon receptor nuclear translocator isoform X3
XM_017001289.2 → XP_016856778.1 aryl hydrocarbon receptor nuclear translocator isoform X2

UniProtKB/TrEMBL

B0AZM1

Conserved Domains (6) summary

smart00091
Location:157 → 221

PAS; PAS domain

cd00130
Location:348 → 444

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:82 → 134

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:154 → 260

PAS; PAS fold

pfam11593
Location:509 → 720

Med3; Mediator complex subunit 3 fungal

pfam14598
Location:348 → 448

PAS_11; PAS domain
XM_047420700.1 → XP_047276656.1 aryl hydrocarbon receptor nuclear translocator isoform X9
XM_017001292.2 → XP_016856781.1 aryl hydrocarbon receptor nuclear translocator isoform X8

UniProtKB/TrEMBL

A8K6P0, B0AZM1
XM_017001288.3 → XP_016856777.1 aryl hydrocarbon receptor nuclear translocator isoform X1

UniProtKB/TrEMBL

A8K6P0
XM_047420713.1 → XP_047276669.1 aryl hydrocarbon receptor nuclear translocator isoform X18
XM_047420709.1 → XP_047276665.1 aryl hydrocarbon receptor nuclear translocator isoform X14
XM_047420743.1 → XP_047276699.1 aryl hydrocarbon receptor nuclear translocator isoform X30
XM_047420712.1 → XP_047276668.1 aryl hydrocarbon receptor nuclear translocator isoform X17
XM_011509543.4 → XP_011507845.1 aryl hydrocarbon receptor nuclear translocator isoform X13

See identical proteins and their annotated locations for XP_011507845.1

UniProtKB/TrEMBL

B4E3L5

Conserved Domains (4) summary

pfam00010
Location:90 → 142

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:162 → 268

PAS; PAS fold

pfam11593
Location:522 → 733

Med3; Mediator complex subunit 3 fungal

cl25986
Location:361 → 461

PAS_3; PAS fold
XM_011509546.3 → XP_011507848.1 aryl hydrocarbon receptor nuclear translocator isoform X21

UniProtKB/TrEMBL

B0AZM1

Conserved Domains (6) summary

smart00091
Location:134 → 198

PAS; PAS domain

cd00130
Location:330 → 426

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:59 → 111

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:131 → 237

PAS; PAS fold

pfam11593
Location:491 → 702

Med3; Mediator complex subunit 3 fungal

pfam14598
Location:330 → 430

PAS_11; PAS domain

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

149933391..150000287 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054336623.1 → XP_054192598.1 aryl hydrocarbon receptor nuclear translocator isoform X29
XM_054336622.1 → XP_054192597.1 aryl hydrocarbon receptor nuclear translocator isoform X28
XM_054336614.1 → XP_054192589.1 aryl hydrocarbon receptor nuclear translocator isoform X20
XM_054336613.1 → XP_054192588.1 aryl hydrocarbon receptor nuclear translocator isoform X19
XM_054336621.1 → XP_054192596.1 aryl hydrocarbon receptor nuclear translocator isoform X27
XM_054336620.1 → XP_054192595.1 aryl hydrocarbon receptor nuclear translocator isoform X26
XM_054336619.1 → XP_054192594.1 aryl hydrocarbon receptor nuclear translocator isoform X25
XM_054336618.1 → XP_054192593.1 aryl hydrocarbon receptor nuclear translocator isoform X24
XM_054336610.1 → XP_054192585.1 aryl hydrocarbon receptor nuclear translocator isoform X16
XM_054336609.1 → XP_054192584.1 aryl hydrocarbon receptor nuclear translocator isoform X15
XM_054336617.1 → XP_054192592.1 aryl hydrocarbon receptor nuclear translocator isoform X23
XM_054336616.1 → XP_054192591.1 aryl hydrocarbon receptor nuclear translocator isoform X22
XM_054336608.1 → XP_054192583.1 aryl hydrocarbon receptor nuclear translocator isoform X12
XM_054336603.1 → XP_054192578.1 aryl hydrocarbon receptor nuclear translocator isoform X7
XM_054336602.1 → XP_054192577.1 aryl hydrocarbon receptor nuclear translocator isoform X6
XM_054336607.1 → XP_054192582.1 aryl hydrocarbon receptor nuclear translocator isoform X11
XM_054336606.1 → XP_054192581.1 aryl hydrocarbon receptor nuclear translocator isoform X10
XM_054336601.1 → XP_054192576.1 aryl hydrocarbon receptor nuclear translocator isoform X5
XM_054336600.1 → XP_054192575.1 aryl hydrocarbon receptor nuclear translocator isoform X4
XM_054336599.1 → XP_054192574.1 aryl hydrocarbon receptor nuclear translocator isoform X3
XM_054336598.1 → XP_054192573.1 aryl hydrocarbon receptor nuclear translocator isoform X2
XM_054336605.1 → XP_054192580.1 aryl hydrocarbon receptor nuclear translocator isoform X9
XM_054336604.1 → XP_054192579.1 aryl hydrocarbon receptor nuclear translocator isoform X8
XM_054336597.1 → XP_054192572.1 aryl hydrocarbon receptor nuclear translocator isoform X1
XM_054336612.1 → XP_054192587.1 aryl hydrocarbon receptor nuclear translocator isoform X18
XM_054336624.1 → XP_054192599.1 aryl hydrocarbon receptor nuclear translocator isoform X30
XM_054336611.1 → XP_054192586.1 aryl hydrocarbon receptor nuclear translocator isoform X17
XM_054336615.1 → XP_054192590.1 aryl hydrocarbon receptor nuclear translocator isoform X21

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_178426.1: Suppressed sequence

Description

NM_178426.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.