U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ighg2c immunoglobulin heavy constant gamma 2C [ Mus musculus (house mouse) ]

Gene ID: 404711, updated on 8-Feb-2024

Summary

Go to the top of the page Help
Official Symbol
Ighg2cprovided by MGI
Official Full Name
immunoglobulin heavy constant gamma 2Cprovided by MGI
Primary source
MGI:MGI:2686979
See related
Ensembl:ENSMUSG00000076612 IMGT/GENE-DB:IGHG2C; AllianceGenome:MGI:2686979
Gene type
other
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Igh-1b
Summary
Enables antigen binding activity. Acts upstream of or within antibacterial humoral response and humoral immune response mediated by circulating immunoglobulin. Located in extracellular space. Part of immunoglobulin complex, circulating. [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
12 F1; 12 62.1 cM
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (113251009..113252552, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (113287389..113288932, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57594 Neighboring gene immunoglobulin heavy constant gamma 2B Neighboring gene immunoglobulin heavy constant alpha Neighboring gene Immunoglobulin heavy constant epsilon Neighboring gene immunoglobulin heavy chain complex

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A novel mouse strain optimized for chronic human antibody administration. Gupta A, et al. Proc Natl Acad Sci U S A, 2022 Mar 8. PMID 35235456, Free PMC Article
  2. The Igh-1 sequence of the non-obese diabetic (NOD) mouse assigns it to the IgG2c isotype. Martin RM, et al. Immunogenetics, 1997. PMID 9162106
  3. An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment. Yang B, et al. J Clin Invest, 2022 Mar 15. PMID 35133976, Free PMC Article
  4. Further evidence that BALB/c and C57BL/6 gamma 2a genes originate from two distinct isotypes. Morgado MG, et al. EMBO J, 1989 Nov. PMID 2510996, Free PMC Article
  5. Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation. Dosenovic P, et al. Immunol Cell Biol, 2015 Feb. PMID 25310967

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Slc15a4 is required for intact function of TLR9-expressing cells and for effective antibody isotype switching to IgG2c.
    Title: Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Other Names

  • immunoglobulin heavy chain 1b (serum IgG2c)

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Fc-gamma receptor I complex binding ISO
Inferred from Sequence Orthology
more info
  
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables antigen binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within antibacterial humoral response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within humoral immune response mediated by circulating immunoglobulin IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within immunoglobulin mediated immune response IDA
Inferred from Direct Assay
more info
  
Component Evidence Code Pubs
part_of IgG immunoglobulin complex ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
part_of immunoglobulin complex, circulating IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of immunoglobulin complex, circulating IDA
Inferred from Direct Assay
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_005838.1 

    Range
    39793..41336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    113251009..113252552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials