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Ano7 anoctamin 7 [ Mus musculus (house mouse) ]

Gene ID: 404545, updated on 11-Apr-2024

Summary

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Official Symbol
Ano7provided by MGI
Official Full Name
anoctamin 7provided by MGI
Primary source
MGI:MGI:3052714
See related
Ensembl:ENSMUSG00000034107 AllianceGenome:MGI:3052714
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ngep; Ngep-L; Pcanap5; Tmem16g
Summary
This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to have little anion conductance activity. In humans, this protein is primarily found in prostate tissues and may serve as a target for prostate cancer immunotherapy. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Dec 2012]
Expression
Biased expression in stomach adult (RPKM 32.3), colon adult (RPKM 26.4) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 D; 1 47.24 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93301518..93332026)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93373796..93404304)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 7 Neighboring gene microRNA 6345 Neighboring gene predicted gene, 26446 Neighboring gene high density lipoprotein (HDL) binding protein Neighboring gene predicted gene, 17415 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95362466-95362649 Neighboring gene STARR-positive B cell enhancer ABC_E1556 Neighboring gene STARR-positive B cell enhancer ABC_E4336 Neighboring gene septin 2 Neighboring gene STARR-positive B cell enhancer ABC_E4337

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate. Bera TK, et al. Proc Natl Acad Sci U S A, 2004 Mar 2. PMID 14981236, Free PMC Article
  2. Evolution and functional divergence of the anoctamin family of membrane proteins. Milenkovic VM, et al. BMC Evol Biol, 2010 Oct 21. PMID 20964844, Free PMC Article
  3. Expression and function of epithelial anoctamins. Schreiber R, et al. J Biol Chem, 2010 Mar 5. PMID 20056604, Free PMC Article
  4. Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. Suzuki J, et al. J Biol Chem, 2013 May 10. PMID 23532839, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables intracellularly calcium-gated chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid scramblase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium activated galactosylceramide scrambling IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within calcium activated phosphatidylcholine scrambling IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within calcium activated phosphatidylserine scrambling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium activated phospholipid scrambling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of localization in cell IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
anoctamin-7
Names
prostate cancer associated protein 5
transmembrane protein 16g

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271884.1 → NP_001258813.1  anoctamin-7 isoform 2

    See identical proteins and their annotated locations for NP_001258813.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site in the 3' coding region which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC108412, AC124669
    Consensus CDS
    CCDS78656.1
    UniProtKB/Swiss-Prot
    Q14AT5
    Related
    ENSMUSP00000050495.6, ENSMUST00000058682.11
    Conserved Domains (2) summary
    pfam04547
    Location:277 → 823
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:52 → 274
    Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

  2. NM_207031.2 → NP_996914.1  anoctamin-7 isoform 1

    See identical proteins and their annotated locations for NP_996914.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC108412, BK004075
    Consensus CDS
    CCDS15188.1
    UniProtKB/Swiss-Prot
    Q14AT5, Q6IFT5
    Related
    ENSMUSP00000140438.2, ENSMUST00000186641.7
    Conserved Domains (2) summary
    pfam04547
    Location:277 → 823
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:52 → 274
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    93301518..93332026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529733.2 → XP_006529796.1  anoctamin-7 isoform X1

    See identical proteins and their annotated locations for XP_006529796.1

    UniProtKB/Swiss-Prot
    Q14AT5, Q6IFT5
    Conserved Domains (2) summary
    pfam04547
    Location:277 → 823
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:52 → 274
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

  2. XM_006529736.2 → XP_006529799.1  anoctamin-7 isoform X4

    Conserved Domains (2) summary
    pfam04547
    Location:258 → 804
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:52 → 255
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

  3. XM_006529734.2 → XP_006529797.1  anoctamin-7 isoform X2

    Conserved Domains (2) summary
    pfam04547
    Location:270 → 816
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:61 → 267
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

  4. XM_006529735.2 → XP_006529798.1  anoctamin-7 isoform X3

    Conserved Domains (2) summary
    pfam04547
    Location:269 → 815
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:60 → 266
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

  5. XM_006529737.2 → XP_006529800.1  anoctamin-7 isoform X5

    Conserved Domains (2) summary
    pfam04547
    Location:210 → 756
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:42 → 207
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

RNA

  1. XR_004933616.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14AT5.2 GenPept UniProtKB/Swiss-Prot:Q14AT5

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