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OR5K4 olfactory receptor family 5 subfamily K member 4 [ Homo sapiens (human) ]

Gene ID: 403278, updated on 5-Mar-2024

Summary

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Official Symbol
OR5K4provided by HGNC
Official Full Name
olfactory receptor family 5 subfamily K member 4provided by HGNC
Primary source
HGNC:HGNC:31291
See related
Ensembl:ENSG00000196098 AllianceGenome:HGNC:31291
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
all
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Genomic context

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Location:
3q11.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (98353854..98354819)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (101057549..101058514)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (98072698..98073663)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373999 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:98010491-98010992 Neighboring gene olfactory receptor family 5 subfamily H member 2 Neighboring gene olfactory receptor family 5 subfamily H member 8 (gene/pseudogene) Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:98043469-98044668 Neighboring gene NANOG hESC enhancer GRCh37_chr3:98045278-98045876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14554 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:98047305-98048042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:98048043-98048779 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20135 Neighboring gene uncharacterized LOC105374000 Neighboring gene olfactory receptor family 5 subfamily K member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
olfactory receptor 5K4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005517.1 → NP_001005517.1  olfactory receptor 5K4

    See identical proteins and their annotated locations for NP_001005517.1

    Status: PROVISIONAL

    Source sequence(s)
    AC108730
    Consensus CDS
    CCDS33802.1
    UniProtKB/Swiss-Prot
    A6NMS3
    UniProtKB/TrEMBL
    A0A126GWS2
    Related
    ENSP00000347003.2, ENST00000354924.2
    Conserved Domains (2) summary
    pfam00001
    Location:41 → 287
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:31 → 302
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    98353854..98354819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    101057549..101058514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NMS3.1 GenPept UniProtKB/Swiss-Prot:A6NMS3

Gene LinkOut

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