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Plcxd1 phosphatidylinositol-specific phospholipase C, X domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 403178, updated on 11-Apr-2024

Summary

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Official Symbol
Plcxd1provided by MGI
Official Full Name
phosphatidylinositol-specific phospholipase C, X domain containing 1provided by MGI
Primary source
MGI:MGI:2685422
See related
Ensembl:ENSMUSG00000064247 AllianceGenome:MGI:2685422
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm576; A330045H12Rik
Summary
Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in cytoplasm. Orthologous to human PLCXD1 (phosphatidylinositol specific phospholipase C X domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 16.9), thymus adult (RPKM 16.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 53.3 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110247661..110253819)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110099969..110105953)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6361 Neighboring gene STARR-seq mESC enhancer starr_13941 Neighboring gene STARR-positive B cell enhancer ABC_E2756 Neighboring gene STARR-seq mESC enhancer starr_13942 Neighboring gene predicted gene, 35315 Neighboring gene STARR-positive B cell enhancer ABC_E3596 Neighboring gene predicted gene, 54335 Neighboring gene STARR-positive B cell enhancer ABC_E4778 Neighboring gene STARR-positive B cell enhancer ABC_E10339 Neighboring gene STARR-positive B cell enhancer ABC_E3597 Neighboring gene GTP binding protein 6 (putative) Neighboring gene zinc finger protein 605 Neighboring gene nucleophosmin pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6362 Neighboring gene STARR-seq mESC enhancer starr_13946 Neighboring gene checkpoint with forkhead and ring finger domains Neighboring gene predicted gene 15787

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice. Goldsworthy M, et al. PLoS One, 2013. PMID 23826075, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphoric diester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
PI-PLC X domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281812.2 → NP_001268741.1  PI-PLC X domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC166747
    Conserved Domains (1) summary
    cl14615
    Location:30 → 235
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  2. NM_001408688.1 → NP_001395617.1  PI-PLC X domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166747

  3. NM_001408689.1 → NP_001395618.1  PI-PLC X domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC166747

  4. NM_001408690.1 → NP_001395619.1  PI-PLC X domain-containing protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC166747

  5. NM_001408691.1 → NP_001395620.1  PI-PLC X domain-containing protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC166747

  6. NM_001408692.1 → NP_001395621.1  PI-PLC X domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166747

  7. NM_207279.3 → NP_997162.2  PI-PLC X domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_997162.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC166747
    Consensus CDS
    CCDS39208.2
    UniProtKB/Swiss-Prot
    Q8BYI5, Q8CHS4
    UniProtKB/TrEMBL
    G3X9J3
    Related
    ENSMUSP00000083892.4, ENSMUST00000086687.10
    Conserved Domains (1) summary
    cd08616
    Location:61 → 351
    PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1

RNA

  1. NR_176795.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166747
    Related
    ENSMUST00000125748.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    110247661..110253819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249507.4 → XP_011247809.1  PI-PLC X domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011247809.1

    UniProtKB/Swiss-Prot
    Q8BYI5, Q8CHS4
    Conserved Domains (1) summary
    cd08616
    Location:11 → 301
    PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1

  2. XM_006535059.4 → XP_006535122.2  PI-PLC X domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8BYI5, Q8CHS4
    Conserved Domains (1) summary
    cd08616
    Location:30 → 320
    PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CHS4.1 GenPept UniProtKB/Swiss-Prot:Q8CHS4

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