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L1RE1 LINE1 retrotransposable element 1 [ Homo sapiens (human) ]

Gene ID: 4029, discontinued on 8-Feb-2018
  • This record has been withdrawn by HGNC and NCBI. It represented an L1 retrotransposon that is present in multiple copies and outside the scope for our representation.

Summary

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Official Symbol
L1RE1provided by HGNC
Official Full Name
LINE1 retrotransposable element 1provided by HGNC
Primary source
HGNC:HGNC:6686
See related
MIM:151626
Gene type
other
RefSeq status
WITHDRAWN
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L1.2; LRE1
Summary
DISCONTINUED: This record has been withdrawn by HGNC and NCBI. It represented an L1 retrotransposon that is present in multiple copies and outside the scope for our representation.
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Genomic context

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Location:
22q12.1

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LINE-1 methylation level appears not to be associated with poor prognosis in PC. (review)
    Title: LINE-1 methylation level and prognosis in pancreas cancer: pyrosequencing technology and literature review.
  2. Results find that the L1 ORF2 protein tolerates the addition of protein domains both at the amino- and carboxy-terminus and that DNA binding domains requiring the formation of multimers for target recognition are unlikely to modify targeting of ORF2p-driven insertions.
    Title: Evaluating different DNA binding domains to modulate L1 ORF2p-driven site-specific retrotransposition events in human cells.
  3. This study highlights the significant difference in L1-ORF2 expression between CTCs and normal samples. The increased expression levels observed for CTCs may be correlated with the characteristic features of these cells.
    Title: L1 retrotransposon expression in circulating tumor cells.
  4. APOBEC3DE inhibits human LINE-1 retrotransposition.
    Title: APOBEC3DE Inhibits LINE-1 Retrotransposition by Interacting with ORF1p and Influencing LINE Reverse Transcriptase Activity.
  5. ADAR1 restricts LINE-1 retrotransposition.
    Title: ADAR1 restricts LINE-1 retrotransposition.
  6. LINE-1 methylation in the non-neoplastic tissue adjacent to tumor was not associated with prostate cancer mortality
    Title: LINE-1 methylation status in prostate cancer and non-neoplastic tissue adjacent to tumor in association with mortality.
  7. identification of amino acids in the L1 ORF2p that is important to retrotransposition (L1 ORF2)
    Title: Identification of L1 ORF2p sequence important to retrotransposition using Bipartile Alu retrotransposition (BAR).
  8. Strong association of single hypomethylated CpG-site in LINE1 with Polycystic ovarian syndrome.
    Title: LINE1 CpG-DNA Hypomethylation in Granulosa Cells and Blood Leukocytes Is Associated With PCOS and Related Traits.
  9. Our results show that L1-ORF2p is overexpressed in tumor and in preneoplastic colon and prostate tissues; this latter finding suggests that ORF2p could be considered as a potential early diagnostic biomarker.
    Title: Enhanced expression of LINE-1-encoded ORF2 protein in early stages of colon and prostate transformation.
  10. As a global epigenetic change, LINE-1 hypomethylation in normal colon mucosa might be associated with a worse outcome in certain Chinese patients with colon cancer.
    Title: LINE-1 hypomethylation in normal colon mucosa is associated with poor survival in Chinese patients with sporadic colon cancer.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Other Names

  • LINE retrotransposable element 1
  • Line-1.2 retrotransposable element
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UN81.1 GenPept UniProtKB/Swiss-Prot:Q9UN81

Gene LinkOut

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