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mTerf3 mitochondrial transcription termination factor 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40279, updated on 4-Apr-2024

Summary

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Official Symbol
mTerf3provided by FlyBase
Official Full Name
mitochondrial transcription termination factor 3provided by FlyBase
Primary source
FLYBASE:FBgn0037008
Locus tag
Dmel_CG5047
See related
AllianceGenome:FB:FBgn0037008
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5047; D-MTERF3; Dmel\CG5047; DmMterf3; DmMTERF3; Mterf3; MTERF3
Summary
Enables large ribosomal subunit rRNA binding activity. Involved in mitochondrial large ribosomal subunit assembly; positive regulation of mitochondrial translation; and regulation of mitochondrial transcription. Located in mitochondrion. Is expressed in organism. Orthologous to human MTERF3 (mitochondrial transcription termination factor 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
77C6-77C6; 3-47 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20519590..20520772, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20512690..20513872, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene BNIP3 Neighboring gene uncharacterized protein Neighboring gene Phosphatidylserine synthase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitotype Interacts With Diet to Influence Longevity, Fitness, and Mitochondrial Functions in Adult Female Drosophila. Towarnicki SG, et al. Front Genet, 2018. PMID 30555517, Free PMC Article
  2. MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals. Wredenberg A, et al. PLoS Genet, 2013. PMID 23300484, Free PMC Article
  3. The complex role of transcription factor GAGA in germline death during Drosophila spermatogenesis: transcriptomic and bioinformatic analyses. Fedorova S, et al. PeerJ, 2023. PMID 36643636, Free PMC Article
  4. MTERF3, the most conserved member of the mTERF-family, is a modular factor involved in mitochondrial protein synthesis. Roberti M, et al. Biochim Biophys Acta, 2006 Sep-Oct. PMID 16787637
  5. D-MTERF5 is a novel factor modulating transcription in Drosophila mitochondria. Bruni F, et al. Mitochondrion, 2012 Sep. PMID 22784680, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We demonstrate here that decreased expression of MTERF3 not only leads to activation of mtDNA transcription, but also impairs assembly of the large mitochondrial ribosomal subunit.
    Title: MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals.
  2. These results indicate that D-MTERF3 is involved in mitochondrial translation.
    Title: MTERF3, the most conserved member of the mTERF-family, is a modular factor involved in mitochondrial protein synthesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables large ribosomal subunit rRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial large ribosomal subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial ribosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in mitochondrial transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitochondrial transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial transcription termination factor 3
Names
CG5047-PA
mTerf3-PA
mitochondrial transcription termination factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20519590..20520772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140983.3 → NP_649240.1  mitochondrial transcription termination factor 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649240.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q06YR8, Q9VPD5
    Related
    FBpp0077873
    Conserved Domains (1) summary
    cl19765
    Location:122 → 307
    mTERF; mTERF
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPD5.1 Q9VPD5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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