LINC01060 long intergenic non-protein coding RNA 1060 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LINC01060provided by HGNC
Official Full Name: long intergenic non-protein coding RNA 1060provided by HGNC
Primary source: HGNC:HGNC:49081
See related: Ensembl:ENSG00000249378 AllianceGenome:HGNC:49081
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression: Biased expression in kidney (RPKM 1.7) and testis (RPKM 0.3) See more
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Genomic context

Location:: 4q35.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (188455578..188601908)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (191802452..191954895)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (189376732..189523062)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LINC01060 knockdown inhibits osteosarcoma cell malignant behaviors in vitro and tumor growth and metastasis in vivo through the PI3K/Akt signaling.
Title: LINC01060 knockdown inhibits osteosarcoma cell malignant behaviors in vitro and tumor growth and metastasis in vivo through the PI3K/Akt signaling.
Hypoxic Glioma Stem Cell-Derived Exosomes Containing Linc01060 Promote Progression of Glioma by Regulating the MZF1/c-Myc/HIF1alpha Axis.
Title: Hypoxic Glioma Stem Cell-Derived Exosomes Containing Linc01060 Promote Progression of Glioma by Regulating the MZF1/c-Myc/HIF1α Axis.
Results show that Linc01060 expression is downregulated in pancreatic tumors and associates with poor prognosis. Further data demonstrate that Linc01060 plays a key role in suppressing pancreatic cancer progression by regulating vinculin expression.
Title: Loss of Linc01060 induces pancreatic cancer progression through vinculin-mediated focal adhesion turnover.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

D4S187 (e-PCR), detects polymorphism
- UniSTS:86093

SHGC-142324 (e-PCR)
- UniSTS:171391

G63213 (e-PCR)
- UniSTS:140187

G10171 (e-PCR)
- UniSTS:21424

WI-22818 (e-PCR)
- UniSTS:8425

G63040 (e-PCR)
- UniSTS:140015

RH121755 (e-PCR)
- UniSTS:134905

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.